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WormBase Tree Display for Gene: WBGene00004035

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Name Class

WBGene00004035SMapS_parentSequenceY73F8A
IdentityVersion1
NameCGC_namepkd-2Person_evidenceWBPerson625
Sequence_nameY73F8A.1
Molecular_nameY73F8A.1
Y73F8A.1.1
CE38663
Other_namepdk-2
CELE_Y73F8A.1Accession_evidenceNDBBX284604
Public_namepkd-2
DB_infoDatabaseAceViewgene4P994
WormQTLgeneWBGene00004035
WormFluxgeneWBGene00004035
OMIMdisease613095
gene173910
NDBlocus_tagCELE_Y73F8A.1
PanthergeneCAEEL|WormBase=WBGene00004035|UniProtKB=Q9U1S7
familyPTHR10877
NCBIgene178424
RefSeqproteinNM_070437.5
SwissProtUniProtAccQ9U1S7
UniProt_GCRPUniProtAccQ9U1S7
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpkd
Allele (134)
StrainWBStrain00026468
WBStrain00030885
WBStrain00031062
WBStrain00031013
RNASeq_FPKM (74)
GO_annotation (66)
Ortholog (57)
ParalogWBGene00003058Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00016889Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionpkd-2 encodes a TRPP cation channel orthologous to human PKD2; pkd-2 is required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location and acts with lov-1; PKD-2 is expressed in the cilia of three types of male-specific sensory neurons; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB neuron.Paper_evidenceWBPaper00003680
WBPaper00004854
WBPaper00006247
Curator_confirmedWBPerson567
Date_last_updated12 Aug 2011 00:00:00
Automated_descriptionEnables calcium channel activity. Involved in calcium ion transport; response to hermaphrodite contact; and vulval location. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and plasma membrane bounded cell projection. Expressed in CEM; nerve ring; neurons; and ray. Used to study autosomal dominant polycystic kidney disease. Human ortholog(s) of this gene implicated in intracranial aneurysm; polycystic kidney disease 2; and retinal degeneration. Is an ortholog of human PKD2 (polycystin 2, transient receptor potential cation channel) and PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:898Homo sapiensPaper_evidenceWBPaper00003680
WBPaper00004854
Accession_evidenceOMIM613095
Curator_confirmedWBPerson324
Date_last_updated30 Apr 2018 00:00:00
Potential_modelDOID:0080322Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9009)
DOID:898Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9009)
DOID:0110859Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9009)
DOID:10941Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9009)
DOID:8466Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9009)
Disease_relevancelov-1 and pkd-2 encode the orthologs of human Polycystin-1 and Polycystin-2, which are mutated in autosomal dominant polycystic kidney disease; the polycystins regulate signaling involved in normal renal tubular structure and function; studies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; in elegans lov-1 and pkd-2 are expressed in male ciliary neurons, are required for normal male mating behavior, do not seem to be required for ciliogenesis, and each polycystin may actually have a potential inhibitory function on the other for ciliary function; lov-1 and pkd-1 interact with a single-pass transmembrane protein, CWP-5, though the significance of this interaction for polycystic kidney disease is unknown.Homo sapiensPaper_evidenceWBPaper00038373
Accession_evidenceOMIM613095
173910
Curator_confirmedWBPerson324
Date_last_updated24 Jan 2012 00:00:00
Models_disease_in_annotationWBDOannot00000033
Models_disease_assertedWBDOannot00000514
Molecular_infoCorresponding_CDSY73F8A.1
Corresponding_CDS_historyY73F8A.1:wp90
Y73F8A.1:wp143
Corresponding_transcriptY73F8A.1.1
Other_sequenceCRC10242_1
CR05211
FK801188.1
JI174536.1
Associated_featureWBsf998698
WBsf998699
WBsf1018743
WBsf1018744
WBsf1018745
WBsf1018746
WBsf231243
Experimental_infoRNAi_resultWBRNAi00066584Inferred_automaticallyRNAi_primary
WBRNAi00000585Inferred_automaticallyRNAi_primary
WBRNAi00021407Inferred_automaticallyRNAi_primary
WBRNAi00021408Inferred_automaticallyRNAi_primary
WBRNAi00058373Inferred_automaticallyRNAi_primary
WBRNAi00112685Inferred_automaticallyRNAi_primary
WBRNAi00037811Inferred_automaticallyRNAi_primary
Expr_pattern (17)
Drives_construct (54)
Construct_product (11)
AntibodyWBAntibody00000407
WBAntibody00002558
WBAntibody00002633
Microarray_results (22)
Expression_cluster (66)
Interaction (66)
WBProcessWBbiopr:00000012
Map_infoMapIVPosition13.0445
PositivePositive_cloneY73F8AInferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4982
Pseudo_map_position
Reference (156)
RemarkThe use of the name pdk-2 for this gene was due to a typo in the original paper [krb 020128]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
[140923 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods.
MethodGene