WormBase Tree Display for Gene: WBGene00003058
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WBGene00003058 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | lov-1 | Person_evidence | WBPerson625 | |||||
Sequence_name | ZK945.9 | ||||||||
Molecular_name | ZK945.9 | ||||||||
ZK945.9.1 | |||||||||
CE45696 | |||||||||
Other_name | pkd-1 | ||||||||
CELE_ZK945.9 | Accession_evidence | NDB | BX284602 | ||||||
Public_name | lov-1 | ||||||||
DB_info | Database | AceView | gene | 2K400 | |||||
WormQTL | gene | WBGene00003058 | |||||||
WormFlux | gene | WBGene00003058 | |||||||
OMIM | disease | 173900 | |||||||
601313 | |||||||||
NDB | locus_tag | CELE_ZK945.9 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003058|UniProtKB=Q09624 | |||||||
family | PTHR10877 | ||||||||
NCBI | gene | 174576 | |||||||
RefSeq | protein | NM_063783.4 | |||||||
SwissProt | UniProtAcc | Q09624 | |||||||
UniProt_GCRP | UniProtAcc | Q09624 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lov | ||||||||
Allele (183) | |||||||||
Strain | WBStrain00030878 | ||||||||
WBStrain00030885 | |||||||||
WBStrain00030886 | |||||||||
WBStrain00031467 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (34) | |||||||||
Ortholog (27) | |||||||||
Paralog | WBGene00004035 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00016889 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | lov-1 encodes a transmembrane protein orthologous to human PKD1; lov-1 is required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location and acts with PKD-2, a TRPP cation channel; LOV-1 is expressed in three types of male-specific neurons and localizes to the cell bodies and cilia; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB hook sensillum neuron; in vitro, LOV-1 interacts, via its conserved PLAT domain, with the N-terminus of ATP-2, the beta subunit of ATP synthase that also localizes to cilia, suggesting that ATP synthase may play a role in C. elegans polycystin signaling. | Paper_evidence | WBPaper00003680 | |||||
WBPaper00004854 | |||||||||
WBPaper00006247 | |||||||||
WBPaper00024944 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 12 Aug 2011 00:00:00 | ||||||||
Automated_description | Enables protein domain specific binding activity. Involved in response to hermaphrodite contact and vulval location. Located in neuronal cell body and non-motile cilium. Expressed in CEM and in male. Used to study autosomal dominant polycystic kidney disease. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:898 | Homo sapiens | Paper_evidence | WBPaper00003680 | ||||
WBPaper00004854 | |||||||||
Accession_evidence | OMIM | 173900 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 30 Apr 2018 00:00:00 | ||||||||
Disease_relevance | lov-1 and pkd-2 encode the orthologs of human Polycystin-1 and Polycystin-2, which are mutated in autosomal dominant polycystic kidney disease; the polycystins regulate signaling involved in normal renal tubular structure and function; studies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; in elegans lov-1 and pkd-2 are expressed in male ciliary neurons, are required for normal male mating behavior, do not seem to be required for ciliogenesis, and each polycystin may actually have a potential inhibitory function on the other for ciliary function; lov-1 and pkd-1 interact with a single-pass transmembrane protein, CWP-5, though the significance of this interaction for polycystic kidney disease is unknown. | Homo sapiens | Paper_evidence | WBPaper00003680 | |||||
Accession_evidence | OMIM | 601313 | |||||||
173900 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 31 Jan 2013 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000024 | ||||||||
WBDOannot00000512 | |||||||||
WBDOannot00000515 | |||||||||
WBDOannot00000516 | |||||||||
Molecular_info | Corresponding_CDS | ZK945.9 | |||||||
Corresponding_CDS_history | ZK945.9:wp188 | ||||||||
ZK945.9:wp222 | |||||||||
Corresponding_transcript | ZK945.9.1 | ||||||||
Other_sequence | JI173898.1 | ||||||||
JO470013.1 | |||||||||
JO468300.1 | |||||||||
JI164556.1 | |||||||||
Associated_feature | WBsf989248 | ||||||||
WBsf1012968 | |||||||||
Experimental_info | RNAi_result (11) | ||||||||
Expr_pattern | Expr1148 | ||||||||
Expr3208 | |||||||||
Expr11946 | |||||||||
Expr1025218 | |||||||||
Expr1163281 | |||||||||
Expr2013249 | |||||||||
Expr2031480 | |||||||||
Drives_construct | WBCnstr00006717 | ||||||||
WBCnstr00010107 | |||||||||
WBCnstr00014864 | |||||||||
WBCnstr00014875 | |||||||||
WBCnstr00019759 | |||||||||
WBCnstr00019881 | |||||||||
WBCnstr00036257 | |||||||||
Construct_product | WBCnstr00014869 | ||||||||
WBCnstr00014875 | |||||||||
WBCnstr00019759 | |||||||||
WBCnstr00036257 | |||||||||
Antibody | WBAntibody00002515 | ||||||||
WBAntibody00002632 | |||||||||
Microarray_results (22) | |||||||||
Expression_cluster (64) | |||||||||
Interaction (58) | |||||||||
WBProcess | WBbiopr:00000012 | ||||||||
Map_info | Map | II | Position | 1.90347 | Error | 0.014559 | |||
Well_ordered | |||||||||
Positive | Positive_clone | ZK945 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 3960 | |||||||
3961 | |||||||||
5093 | |||||||||
Pos_neg_data | 10577 | ||||||||
10578 | |||||||||
10579 | |||||||||
10580 | |||||||||
10581 | |||||||||
10582 | |||||||||
Reference (101) | |||||||||
Method | Gene |