WormBase Tree Display for Gene: WBGene00003058
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| WBGene00003058 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lov-1 | Person_evidence | WBPerson625 | |||||
| Sequence_name | ZK945.9 | ||||||||
| Molecular_name | ZK945.9 | ||||||||
| ZK945.9.1 | |||||||||
| CE45696 | |||||||||
| Other_name | pkd-1 | ||||||||
| CELE_ZK945.9 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | lov-1 | ||||||||
| DB_info | Database | AceView | gene | 2K400 | |||||
| WormQTL | gene | WBGene00003058 | |||||||
| WormFlux | gene | WBGene00003058 | |||||||
| OMIM | disease | 173900 | |||||||
| 601313 | |||||||||
| NDB | locus_tag | CELE_ZK945.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003058|UniProtKB=Q09624 | |||||||
| family | PTHR10877 | ||||||||
| NCBI | gene | 174576 | |||||||
| RefSeq | protein | NM_063783.4 | |||||||
| SwissProt | UniProtAcc | Q09624 | |||||||
| UniProt_GCRP | UniProtAcc | Q09624 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lov | ||||||||
| Allele (183) | |||||||||
| Strain | WBStrain00030878 | ||||||||
| WBStrain00030885 | |||||||||
| WBStrain00030886 | |||||||||
| WBStrain00031467 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Ortholog (27) | |||||||||
| Paralog | WBGene00004035 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00016889 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description (2) | |||||||||
| Disease_info | Experimental_model | DOID:898 | Homo sapiens | Paper_evidence | WBPaper00003680 | ||||
| WBPaper00004854 | |||||||||
| Accession_evidence | OMIM | 173900 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 30 Apr 2018 00:00:00 | ||||||||
| Disease_relevance | lov-1 and pkd-2 encode the orthologs of human Polycystin-1 and Polycystin-2, which are mutated in autosomal dominant polycystic kidney disease; the polycystins regulate signaling involved in normal renal tubular structure and function; studies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; in elegans lov-1 and pkd-2 are expressed in male ciliary neurons, are required for normal male mating behavior, do not seem to be required for ciliogenesis, and each polycystin may actually have a potential inhibitory function on the other for ciliary function; lov-1 and pkd-1 interact with a single-pass transmembrane protein, CWP-5, though the significance of this interaction for polycystic kidney disease is unknown. | Homo sapiens | Paper_evidence | WBPaper00003680 | |||||
| Accession_evidence | OMIM | 601313 | |||||||
| 173900 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 31 Jan 2013 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000024 | ||||||||
| WBDOannot00000512 | |||||||||
| WBDOannot00000515 | |||||||||
| WBDOannot00000516 | |||||||||
| Molecular_info | Corresponding_CDS | ZK945.9 | |||||||
| Corresponding_CDS_history | ZK945.9:wp188 | ||||||||
| ZK945.9:wp222 | |||||||||
| Corresponding_transcript | ZK945.9.1 | ||||||||
| Other_sequence | JI173898.1 | ||||||||
| JO470013.1 | |||||||||
| JO468300.1 | |||||||||
| JI164556.1 | |||||||||
| Associated_feature | WBsf989248 | ||||||||
| WBsf1012968 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr1148 | ||||||||
| Expr3208 | |||||||||
| Expr11946 | |||||||||
| Expr1025218 | |||||||||
| Expr1163281 | |||||||||
| Expr2013249 | |||||||||
| Expr2031480 | |||||||||
| Drives_construct | WBCnstr00006717 | ||||||||
| WBCnstr00010107 | |||||||||
| WBCnstr00014864 | |||||||||
| WBCnstr00014875 | |||||||||
| WBCnstr00019759 | |||||||||
| WBCnstr00019881 | |||||||||
| WBCnstr00036257 | |||||||||
| Construct_product | WBCnstr00014869 | ||||||||
| WBCnstr00014875 | |||||||||
| WBCnstr00019759 | |||||||||
| WBCnstr00036257 | |||||||||
| Antibody | WBAntibody00002515 | ||||||||
| WBAntibody00002632 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (64) | |||||||||
| Interaction (58) | |||||||||
| WBProcess | WBbiopr:00000012 | ||||||||
| Map_info | Map | II | Position | 1.90347 | Error | 0.014559 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | ZK945 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3960 | |||||||
| 3961 | |||||||||
| 5093 | |||||||||
| Pos_neg_data | 10577 | ||||||||
| 10578 | |||||||||
| 10579 | |||||||||
| 10580 | |||||||||
| 10581 | |||||||||
| 10582 | |||||||||
| Reference (101) | |||||||||
| Method | Gene |
