WormBase Tree Display for Gene: WBGene00004035
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| WBGene00004035 | SMap | S_parent | Sequence | Y73F8A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pkd-2 | Person_evidence | WBPerson625 | |||||
| Sequence_name | Y73F8A.1 | ||||||||
| Molecular_name | Y73F8A.1 | ||||||||
| Y73F8A.1.1 | |||||||||
| CE38663 | |||||||||
| Other_name | pdk-2 | ||||||||
| CELE_Y73F8A.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | pkd-2 | ||||||||
| DB_info | Database | AceView | gene | 4P994 | |||||
| WormQTL | gene | WBGene00004035 | |||||||
| WormFlux | gene | WBGene00004035 | |||||||
| OMIM | disease | 613095 | |||||||
| gene | 173910 | ||||||||
| NDB | locus_tag | CELE_Y73F8A.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004035|UniProtKB=Q9U1S7 | |||||||
| family | PTHR10877 | ||||||||
| NCBI | gene | 178424 | |||||||
| RefSeq | protein | NM_070437.5 | |||||||
| SwissProt | UniProtAcc | Q9U1S7 | |||||||
| UniProt_GCRP | UniProtAcc | Q9U1S7 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pkd | ||||||||
| Allele (134) | |||||||||
| Strain | WBStrain00026468 | ||||||||
| WBStrain00030885 | |||||||||
| WBStrain00031062 | |||||||||
| WBStrain00031013 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (66) | |||||||||
| Ortholog (57) | |||||||||
| Paralog | WBGene00003058 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00016889 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | pkd-2 encodes a TRPP cation channel orthologous to human PKD2; pkd-2 is required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location and acts with lov-1; PKD-2 is expressed in the cilia of three types of male-specific sensory neurons; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB neuron. | Paper_evidence | WBPaper00003680 | |||||
| WBPaper00004854 | |||||||||
| WBPaper00006247 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 12 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables calcium channel activity. Involved in calcium ion transport; response to hermaphrodite contact; and vulval location. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and plasma membrane bounded cell projection. Expressed in CEM; nerve ring; neurons; and ray. Used to study autosomal dominant polycystic kidney disease. Human ortholog(s) of this gene implicated in intracranial aneurysm; polycystic kidney disease 2; and retinal degeneration. Is an ortholog of human PKD2 (polycystin 2, transient receptor potential cation channel) and PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:898 | Homo sapiens | Paper_evidence | WBPaper00003680 | ||||
| WBPaper00004854 | |||||||||
| Accession_evidence | OMIM | 613095 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 30 Apr 2018 00:00:00 | ||||||||
| Potential_model | DOID:0080322 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) | |||||
| DOID:898 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) | ||||||
| DOID:0110859 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) | ||||||
| DOID:10941 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) | ||||||
| DOID:8466 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) | ||||||
| Disease_relevance | lov-1 and pkd-2 encode the orthologs of human Polycystin-1 and Polycystin-2, which are mutated in autosomal dominant polycystic kidney disease; the polycystins regulate signaling involved in normal renal tubular structure and function; studies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; in elegans lov-1 and pkd-2 are expressed in male ciliary neurons, are required for normal male mating behavior, do not seem to be required for ciliogenesis, and each polycystin may actually have a potential inhibitory function on the other for ciliary function; lov-1 and pkd-1 interact with a single-pass transmembrane protein, CWP-5, though the significance of this interaction for polycystic kidney disease is unknown. | Homo sapiens | Paper_evidence | WBPaper00038373 | |||||
| Accession_evidence | OMIM | 613095 | |||||||
| 173910 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Jan 2012 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000033 | ||||||||
| Models_disease_asserted | WBDOannot00000514 | ||||||||
| Molecular_info | Corresponding_CDS | Y73F8A.1 | |||||||
| Corresponding_CDS_history | Y73F8A.1:wp90 | ||||||||
| Y73F8A.1:wp143 | |||||||||
| Corresponding_transcript | Y73F8A.1.1 | ||||||||
| Other_sequence | CRC10242_1 | ||||||||
| CR05211 | |||||||||
| FK801188.1 | |||||||||
| JI174536.1 | |||||||||
| Associated_feature | WBsf998698 | ||||||||
| WBsf998699 | |||||||||
| WBsf1018743 | |||||||||
| WBsf1018744 | |||||||||
| WBsf1018745 | |||||||||
| WBsf1018746 | |||||||||
| WBsf231243 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00066584 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00000585 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021407 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021408 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00058373 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112685 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00037811 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (17) | |||||||||
| Drives_construct | WBCnstr00000133 | ||||||||
| WBCnstr00000134 | |||||||||
| WBCnstr00000180 | |||||||||
| WBCnstr00000347 | |||||||||
| WBCnstr00001230 | |||||||||
| WBCnstr00001231 | |||||||||
| WBCnstr00001232 | |||||||||
| WBCnstr00001281 | |||||||||
| WBCnstr00001282 | |||||||||
| WBCnstr00004598 | |||||||||
| WBCnstr00004599 | |||||||||
| WBCnstr00004977 | |||||||||
| WBCnstr00006285 | |||||||||
| WBCnstr00006667 | |||||||||
| WBCnstr00006718 | |||||||||
| WBCnstr00007259 | |||||||||
| WBCnstr00008692 | |||||||||
| WBCnstr00009026 | |||||||||
| WBCnstr00009454 | |||||||||
| WBCnstr00009457 | |||||||||
| WBCnstr00011422 | |||||||||
| WBCnstr00012942 | |||||||||
| WBCnstr00012943 | |||||||||
| WBCnstr00013005 | |||||||||
| WBCnstr00013071 | |||||||||
| WBCnstr00013201 | |||||||||
| WBCnstr00013202 | |||||||||
| WBCnstr00013904 | |||||||||
| WBCnstr00014860 | |||||||||
| WBCnstr00014861 | |||||||||
| WBCnstr00014865 | |||||||||
| WBCnstr00014867 | |||||||||
| WBCnstr00014868 | |||||||||
| WBCnstr00014871 | |||||||||
| WBCnstr00014872 | |||||||||
| WBCnstr00014873 | |||||||||
| WBCnstr00014874 | |||||||||
| WBCnstr00014876 | |||||||||
| WBCnstr00014877 | |||||||||
| WBCnstr00014878 | |||||||||
| WBCnstr00014879 | |||||||||
| WBCnstr00014880 | |||||||||
| WBCnstr00014881 | |||||||||
| WBCnstr00014884 | |||||||||
| WBCnstr00014885 | |||||||||
| WBCnstr00014886 | |||||||||
| WBCnstr00014887 | |||||||||
| WBCnstr00014888 | |||||||||
| WBCnstr00015605 | |||||||||
| WBCnstr00017219 | |||||||||
| WBCnstr00019760 | |||||||||
| WBCnstr00022885 | |||||||||
| WBCnstr00038231 | |||||||||
| WBCnstr00040899 | |||||||||
| Construct_product (11) | |||||||||
| Antibody | WBAntibody00000407 | ||||||||
| WBAntibody00002558 | |||||||||
| WBAntibody00002633 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (66) | |||||||||
| Interaction (66) | |||||||||
| WBProcess | WBbiopr:00000012 | ||||||||
| Map_info | Map | IV | Position | 13.0445 | |||||
| Positive | Positive_clone | Y73F8A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4982 | |||||||
| Pseudo_map_position | |||||||||
| Reference (156) | |||||||||
| Remark | The use of the name pdk-2 for this gene was due to a typo in the original paper [krb 020128] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| [140923 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. | |||||||||
| Method | Gene |
