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WormBase Tree Display for Gene: WBGene00003999

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Name Class

WBGene00003999SMapS_parentSequenceC05A9
IdentityVersion1
NameCGC_namepgp-5Person_evidenceWBPerson490
Sequence_nameC05A9.1
Molecular_nameC05A9.1a
C05A9.1a.1
CE43003
C05A9.1b
CE43182
C05A9.1b.1
Other_nameCELE_C05A9.1Accession_evidenceNDBBX284606
Public_namepgp-5
DB_infoDatabaseAceViewgeneXL474
WormQTLgeneWBGene00003999
WormFluxgeneWBGene00003999
NDBlocus_tagCELE_C05A9.1
PanthergeneCAEEL|WormBase=WBGene00003999|UniProtKB=Q17645
familyPTHR24221
NCBIgene181276
RefSeqproteinNM_001270188.3
NM_001270187.3
TrEMBLUniProtAccB6VQ78
Q17645
UniProt_GCRPUniProtAccQ17645
OMIMgene171050
171060
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpgp
Allele (76)
StrainWBStrain00031670
RNASeq_FPKM (74)
GO_annotation (26)
Ortholog (45)
Paralog (23)
Structured_descriptionConcise_descriptionpgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; pgp-5 activity is required for defense response to both Gram-negative and Gram-positive bacteria as well as for the response to heavy metal ions, including cadmium, copper, and zinc; pgp-5 is expressed in the intestine as well as in the terminal bulb of the pharynx; basal pgp-5 intestinal expression is regulated by TIR-1, while increased expression in response to stressors is under the contol of the p38 MAPK pathway.Paper_evidenceWBPaper00004651
WBPaper00005654
WBPaper00031023
Curator_confirmedWBPerson1843
Date_last_updated14 Apr 2014 00:00:00
Automated_descriptionPredicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in several processes, including defense response to bacterium; response to nematicide; and stress response to metal ion. Predicted to be located in plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1) and ABCB4 (ATP binding cassette subfamily B member 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (39)
Molecular_infoCorresponding_CDSC05A9.1a
C05A9.1b
Corresponding_CDS_historyC05A9.1:wp194
Corresponding_transcriptC05A9.1a.1
C05A9.1b.1
Other_sequenceES741656.1
Name_isotig09110
JI225225.1
AF128532.1
Tcol_isotig19406
MC00124
HBC03410_1
Associated_featureWBsf654366
WBsf670999
WBsf1006839
WBsf1006840
WBsf237901
Experimental_infoRNAi_resultWBRNAi00007288Inferred_automaticallyRNAi_primary
WBRNAi00028469Inferred_automaticallyRNAi_primary
WBRNAi00010165Inferred_automaticallyRNAi_primary
WBRNAi00094617Inferred_automaticallyRNAi_primary
WBRNAi00039681Inferred_automaticallyRNAi_primary
Expr_patternChronogram1654
Expr3335
Expr3336
Expr12159
Expr1013923
Expr1143777
Expr2014872
Expr2033107
Drives_constructWBCnstr00000017
WBCnstr00002012
WBCnstr00011331
WBCnstr00011332
WBCnstr00035751
Construct_productWBCnstr00035751
Microarray_results (24)
Expression_cluster (297)
InteractionWBInteraction000244614
WBInteraction000244615
WBInteraction000285593
WBInteraction000319877
WBInteraction000386938
WBInteraction000424143
WBInteraction000462127
WBInteraction000465320
WBInteraction000503034
WBInteraction000519393
WBInteraction000520129
WBInteraction000542659
WBInteraction000549535
WBInteraction000549536
WBInteraction000549813
WBInteraction000549818
WBInteraction000549819
WBInteraction000549821
WBInteraction000549822
WBInteraction000549823
WBInteraction000549825
WBInteraction000549826
WBInteraction000549838
WBInteraction000549839
WBInteraction000549840
WBInteraction000549841
WBInteraction000549842
WBInteraction000549843
WBInteraction000549844
WBInteraction000549845
WBInteraction000549846
WBInteraction000549847
WBInteraction000549848
WBInteraction000549849
WBInteraction000549850
WBInteraction000549851
WBInteraction000549852
WBInteraction000549853
WBInteraction000549854
WBInteraction000549855
WBInteraction000549856
WBInteraction000549857
WBInteraction000549858
WBInteraction000549859
WBInteraction000549860
WBInteraction000549861
WBInteraction000549862
WBInteraction000549863
WBInteraction000549864
WBInteraction000549865
WBInteraction000549866
WBInteraction000549867
WBInteraction000549868
WBInteraction000549869
WBInteraction000549877
WBInteraction000549878
WBInteraction000549879
WBInteraction000549880
WBInteraction000549881
WBInteraction000549882
WBInteraction000549883
WBInteraction000549884
WBInteraction000549885
WBInteraction000549886
WBInteraction000549887
WBInteraction000549888
WBInteraction000549889
WBInteraction000549890
WBInteraction000549891
WBInteraction000549892
WBInteraction000549894
WBInteraction000549895
WBInteraction000549896
WBInteraction000549897
WBInteraction000549898
WBInteraction000549899
WBInteraction000549900
WBInteraction000549901
WBInteraction000549902
WBInteraction000549903
WBInteraction000549904
WBInteraction000549905
WBInteraction000549906
WBInteraction000549907
WBInteraction000549908
WBInteraction000549909
WBInteraction000549910
WBInteraction000549911
WBInteraction000549912
WBInteraction000549913
WBInteraction000549914
WBInteraction000549915
WBInteraction000549916
WBInteraction000549921
WBInteraction000549922
WBInteraction000549923
WBInteraction000549924
WBInteraction000549927
WBInteraction000549928
WBInteraction000549929
WBInteraction000549930
WBInteraction000549931
WBInteraction000549932
WBInteraction000549933
WBInteraction000549934
WBInteraction000549935
WBInteraction000549936
WBInteraction000549937
WBInteraction000549946
WBInteraction000549947
WBInteraction000549948
WBInteraction000549949
WBInteraction000549950
WBInteraction000549951
WBInteraction000549955
WBInteraction000549956
WBInteraction000580244
WBInteraction000583081
WBInteraction000585762
WBProcessWBbiopr:00000008
WBbiopr:00000039
Map_infoMapXPosition2.56721Error0.00819
PositivePositive_cloneC05A9Inferred_automatically (2)
Mapping_dataMulti_point4579
Pseudo_map_position
Reference (19)
RemarkSequence connection from [Sheps JA, Baillie DL] [040902 ck1]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene