WormBase Tree Display for Gene: WBGene00003931

WBGene00003931 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 1
    Name: CGC_name: pat-4 Person_evidence: WBPerson1562
      Sequence_name: C29F9.7
      Molecular_name: C29F9.7
        C29F9.7.1
        CE19706
      Other_name: CELE_C29F9.7 Accession_evidence: NDB BX284603
      Public_name: pat-4
    DB_info: Database: AceView gene 3A708
        WormQTL gene WBGene00003931
        WormFlux gene WBGene00003931
        NDB locus_tag CELE_C29F9.7
        Panther gene CAEEL|WormBase=WBGene00003931|UniProtKB=Q9TZC4
          family PTHR44329
        NCBI gene 175175
        RefSeq protein NM_064738.8
        SwissProt UniProtAcc Q9TZC4
        TREEFAM TREEFAM_ID TF315194
        UniProt_GCRP UniProtAcc Q9TZC4
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pat
    Allele: WBVar00248770
      WBVar00248789
      WBVar02124464
      WBVar00026213
      WBVar02121153
      WBVar01387751
      WBVar00026218
      WBVar02101096
      WBVar01387761
      WBVar01961437
      WBVar02101097
      WBVar01387762
      WBVar00026223
      WBVar02101098
      WBVar01961438
      WBVar02101099
      WBVar02131305
      WBVar02101100
      WBVar01387779
      WBVar00026228
      WBVar01387794
      WBVar01387795
      WBVar00026233
      WBVar01387796
      WBVar01500082
      WBVar01387802
      WBVar01387805
      WBVar00026238
      WBVar02099452
      WBVar02069318
      WBVar02069319
      WBVar01387812
      WBVar00026243
      WBVar02069320
      WBVar00026248
      WBVar01902739
      WBVar01902740
      WBVar00026253
      WBVar01478935
      WBVar01478936
      WBVar01950956
      WBVar00026258
      WBVar01950957
      WBVar01950958
      WBVar01950959
      WBVar00026263
      WBVar01950960
      WBVar01950961
      WBVar00026268
      WBVar01950962
      WBVar00026273
      WBVar00026278
      WBVar00026283
      WBVar01563786
      WBVar00026288
      WBVar01563787
      WBVar01563788
      WBVar00026293
      WBVar01563789
      WBVar01563790
      WBVar01498832
      WBVar01563791
      WBVar00026298
      WBVar01563792
      WBVar01563793
      WBVar01563794
      WBVar00026303
      WBVar01563795
      WBVar01706151
      WBVar01563796
      WBVar01706152
      WBVar01563797
      WBVar01563798
      WBVar01706153
      WBVar01270629
      WBVar00026308
      WBVar01706154
      WBVar02029764
      WBVar02029765
      WBVar01706155
      WBVar02029766
      WBVar00026313
      WBVar01706156
      WBVar02029767
      WBVar01498659
      WBVar00026318
      WBVar00558470
      WBVar00558471
      WBVar00558473
      WBVar00026323
      WBVar00558474
      WBVar00558475
      WBVar02106681
      WBVar02106682
      WBVar00558476
      WBVar00558486
      WBVar00558489
      WBVar01767938
      WBVar01767939
      WBVar00558491
      WBVar01697854
      WBVar01697855
      WBVar01767940
      WBVar00558492
      WBVar01697856
      WBVar00558495
      WBVar01767941
      WBVar01767942
      WBVar00558498
      WBVar01697857
      WBVar01767943
      WBVar01697858
      WBVar00558499
      WBVar01767944
      WBVar00558500
      WBVar01697859
      WBVar01767945
      WBVar00259177
      WBVar01697860
      WBVar00558503
      WBVar01767946
      WBVar00558504
      WBVar01697861
      WBVar01767947
      WBVar01697862
      WBVar01697863
      WBVar01767948
      WBVar01767949
      WBVar01697864
      WBVar01697865
      WBVar01767950
      WBVar01697866
      WBVar01697867
      WBVar01697868
      WBVar01697869
      WBVar01697870
      WBVar01697871
      WBVar01697872
      WBVar02117563
      WBVar01697873
      WBVar00601363
      WBVar01697874
      WBVar02117564
      WBVar01697875
      WBVar01697876
      WBVar01697877
      WBVar01697878
      WBVar01697879
      WBVar01697880
      WBVar01697881
      WBVar01697882
      WBVar01697883
      WBVar01697884
      WBVar01697885
      WBVar02014547
      WBVar00794988
      WBVar00794989
      WBVar01697886
      WBVar01697887
      WBVar00794990
      WBVar01697888
      WBVar00794991
      WBVar01697889
      WBVar00794992
      WBVar00026083
      WBVar01697890
      WBVar00794993
      WBVar00794994
      WBVar01697891
      WBVar00026088
      WBVar00794995
      WBVar01697892
      WBVar01697893
      WBVar00794996
      WBVar02071641
      WBVar01697894
      WBVar00794997
      WBVar00794998
      WBVar00026093
      WBVar01577601
      WBVar01697895
      WBVar01697896
      WBVar01577602
      WBVar00794999
      WBVar00795000
      WBVar01697897
      WBVar01577603
      WBVar01577604
      WBVar01912437
      WBVar01697898
      WBVar00026098
      WBVar00795001
      WBVar02122373
      WBVar01577605
      WBVar01912438
      WBVar01697899
      WBVar00795002
      WBVar01697900
      WBVar01912439
      WBVar00795003
      WBVar01577606
      WBVar00026103
      WBVar00795004
      WBVar01697901
      WBVar01912440
      WBVar01577607
      WBVar01697902
      WBVar00795005
      WBVar01577608
      WBVar01912441
      WBVar00795006
      WBVar01577609
      WBVar01697903
      WBVar00795007
      WBVar01395571
      WBVar01697904
      WBVar00026108
      WBVar01577610
      WBVar01697905
      WBVar01577611
      WBVar00795008
      WBVar01577612
      WBVar00795009
      WBVar01697906
      WBVar00026113
      WBVar01577613
      WBVar00795010
      WBVar01697907
      WBVar01697908
      WBVar00795011
      WBVar01577614
      WBVar01697909
      WBVar01577615
      WBVar00795012
      WBVar01577616
      WBVar00795013
      WBVar01697910
      WBVar00026118
      WBVar01577617
      WBVar00795014
      WBVar01697911
      WBVar01697912
      WBVar00795015
      WBVar01577618
      WBVar01697913
      WBVar00026123
      WBVar01577619
      WBVar00248762
      WBVar00795016
      WBVar01697914
      WBVar00795017
      WBVar01577620
      WBVar01577621
      WBVar00795018
      WBVar01697915
      WBVar00795019
      WBVar00026128
      WBVar01697916
      WBVar00795020
      WBVar01697917
      WBVar00248788
      WBVar01697918
      WBVar00795021
      WBVar02089453
      WBVar01697919
      WBVar00026133
      WBVar02089454
      WBVar01697920
      WBVar00387217
      WBVar01697921
      WBVar02089455
      WBVar00026138
      WBVar01697922
      WBVar00387218
      WBVar01697923
      WBVar00387219
      WBVar01697924
      WBVar00387220
      WBVar02007326
      WBVar00387221
      WBVar00026143
      WBVar01697925
      WBVar02007327
      WBVar00387222
      WBVar01697926
      WBVar02007328
      WBVar01398723
      WBVar00387223
      WBVar01697927
      WBVar00026148
      WBVar00387224
      WBVar01697928
      WBVar00387225
      WBVar01498561
      WBVar00387226
      WBVar01398734
      WBVar00026153
      WBVar00026158
      WBVar01398745
      WBVar00026163
      WBVar00026168
      WBVar00026173
      WBVar01254466
      WBVar00026178
      WBVar01540498
      WBVar00026183
      WBVar00026188
      WBVar00026193
      WBVar02073956
      WBVar00026198
      WBVar00007631
      WBVar00026203
    Legacy_information: [Williams DB] Severe Pat phenotype, all alleles similar
      [C.elegansII] st552 : severe Pat phenotype. OA3: st551, st579, st580 (all similar). [Williams and Waterston 1994; RW]
      [MacKinnon C] Predicted gene C29F9.7, encoding homologue of vertebrate integrin-linked kinase
    Strain: WBStrain00002637
      WBStrain00033521
      WBStrain00040330
    RNASeq_FPKM (74)
    GO_annotation (46)
    Ortholog (34)
    Paralog (11)
    Structured_description: Concise_description: The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes. Paper_evidence: WBPaper00005261
            WBPaper00005915
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables integrin binding activity and protein-macromolecule adaptor activity. Involved in several processes, including integrin-mediated signaling pathway; organelle organization; and positive regulation of supramolecular fiber organization. Located in adherens junction; basal plasma membrane; and contractile fiber. Part of integrin complex. Expressed in body wall musculature; gonad; non-striated muscle; pharynx; and touch receptor neurons. Human ortholog(s) of this gene implicated in ovarian cancer; pancreatic cancer; and prostate adenocarcinoma. Is an ortholog of human ILK (integrin linked kinase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6040)
      DOID:1793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6040)
      DOID:2526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6040)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6040)
  Molecular_info: Corresponding_CDS: C29F9.7
    Corresponding_transcript: C29F9.7.1
    Other_sequence (89)
    Associated_feature: WBsf990981
      WBsf226082
      WBsf226083
  Experimental_info: RNAi_result (40)
    Expr_pattern: Chronogram438
      Expr1888
      Expr5379
      Expr11437
      Expr14519
      Expr1010218
      Expr1031864
      Expr1145524
      Expr2014752
      Expr2032986
    Drives_construct: WBCnstr00003184
      WBCnstr00010504
      WBCnstr00021447
      WBCnstr00041071
    Construct_product: WBCnstr00010504
      WBCnstr00019202
      WBCnstr00021626
      WBCnstr00021697
      WBCnstr00041071
    Antibody: WBAntibody00000510
      WBAntibody00002369
    Microarray_results (19)
    Expression_cluster (141)
    Interaction (83)
    WBProcess: WBbiopr:00000006
  Map_info: Map: III Position: -26.9858 Error: 0.037333
    Well_ordered
    Positive: Positive_clone: C29F9 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3016
        3017
  Reference (49)
  Remark: Data extracted from Williams & Waterston 1994
    Sequence connection from [Rogalski TM, Williams BD]
  Method: Gene