WormBase Tree Display for Gene: WBGene00003931
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| WBGene00003931 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_III | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | pat-4 | Person_evidence | WBPerson1562 | |||||
| Sequence_name | C29F9.7 | ||||||||
| Molecular_name | C29F9.7 | ||||||||
| C29F9.7.1 | |||||||||
| CE19706 | |||||||||
| Other_name | CELE_C29F9.7 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | pat-4 | ||||||||
| DB_info | Database | AceView | gene | 3A708 | |||||
| WormQTL | gene | WBGene00003931 | |||||||
| WormFlux | gene | WBGene00003931 | |||||||
| NDB | locus_tag | CELE_C29F9.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003931|UniProtKB=Q9TZC4 | |||||||
| family | PTHR44329 | ||||||||
| NCBI | gene | 175175 | |||||||
| RefSeq | protein | NM_064738.8 | |||||||
| SwissProt | UniProtAcc | Q9TZC4 | |||||||
| TREEFAM | TREEFAM_ID | TF315194 | |||||||
| UniProt_GCRP | UniProtAcc | Q9TZC4 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pat | ||||||||
| Allele (312) | |||||||||
| Legacy_information | [Williams DB] Severe Pat phenotype, all alleles similar | ||||||||
| [C.elegansII] st552 : severe Pat phenotype. OA3: st551, st579, st580 (all similar). [Williams and Waterston 1994; RW] | |||||||||
| [MacKinnon C] Predicted gene C29F9.7, encoding homologue of vertebrate integrin-linked kinase | |||||||||
| Strain | WBStrain00002637 | ||||||||
| WBStrain00033521 | |||||||||
| WBStrain00040330 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (46) | |||||||||
| Ortholog (34) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes. | Paper_evidence | WBPaper00005261 | |||||
| WBPaper00005915 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables integrin binding activity and protein-macromolecule adaptor activity. Involved in several processes, including integrin-mediated signaling pathway; organelle organization; and positive regulation of supramolecular fiber organization. Located in adherens junction; basal plasma membrane; and contractile fiber. Part of integrin complex. Expressed in body wall musculature; gonad; non-striated muscle; pharynx; and touch receptor neurons. Human ortholog(s) of this gene implicated in ovarian cancer; pancreatic cancer; and prostate adenocarcinoma. Is an ortholog of human ILK (integrin linked kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||||
| DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||||||
| DOID:2526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||||||
| DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||||||
| Molecular_info | Corresponding_CDS | C29F9.7 | |||||||
| Corresponding_transcript | C29F9.7.1 | ||||||||
| Other_sequence (89) | |||||||||
| Associated_feature | WBsf990981 | ||||||||
| WBsf226082 | |||||||||
| WBsf226083 | |||||||||
| Experimental_info | RNAi_result (40) | ||||||||
| Expr_pattern | Chronogram438 | ||||||||
| Expr1888 | |||||||||
| Expr5379 | |||||||||
| Expr11437 | |||||||||
| Expr14519 | |||||||||
| Expr1010218 | |||||||||
| Expr1031864 | |||||||||
| Expr1145524 | |||||||||
| Expr2014752 | |||||||||
| Expr2032986 | |||||||||
| Drives_construct | WBCnstr00003184 | ||||||||
| WBCnstr00010504 | |||||||||
| WBCnstr00021447 | |||||||||
| WBCnstr00041071 | |||||||||
| Construct_product | WBCnstr00010504 | ||||||||
| WBCnstr00019202 | |||||||||
| WBCnstr00021626 | |||||||||
| WBCnstr00021697 | |||||||||
| WBCnstr00041071 | |||||||||
| Antibody | WBAntibody00000510 | ||||||||
| WBAntibody00002369 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (141) | |||||||||
| Interaction (83) | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| Map_info | Map | III | Position | -26.9858 | Error | 0.037333 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C29F9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3016 | |||||||
| 3017 | |||||||||
| Reference (49) | |||||||||
| Remark | Data extracted from Williams & Waterston 1994 | ||||||||
| Sequence connection from [Rogalski TM, Williams BD] | |||||||||
| Method | Gene |
