WormBase Tree Display for Gene: WBGene00003772

WBGene00003772 Evidence: Author_evidence: Haklai-Toper L
  SMap: S_parent: Sequence: F20B10
  Identity: Version: 1
    Name: CGC_name: nlr-1
      Sequence_name: F20B10.1
      Molecular_name: F20B10.1
        F20B10.1.1
        CE40647
      Other_name: CELE_F20B10.1 Accession_evidence: NDB BX284604
      Public_name: nlr-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nlr
    Allele (83)
    Strain: WBStrain00036730
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (47)
    Paralog (49)
    Structured_description: Automated_description: Enables actin filament binding activity and gap junction channel activity. Involved in positive regulation of gap junction assembly and positive regulation of pharyngeal pumping. Located in gap junction. Expressed in RIS; pharyngeal gland cell; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including Pitt-Hopkins syndrome; autistic disorder; and communication disorder (multiple). Is an ortholog of human CNTNAP5 (contactin associated protein family member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (15)
  Molecular_info: Corresponding_CDS: F20B10.1
    Corresponding_CDS_history: F20B10.1:wp169
    Corresponding_transcript: F20B10.1.1
    Other_sequence (20)
    Associated_feature (18)
  Experimental_info: RNAi_result: WBRNAi00045068 Inferred_automatically: RNAi_primary
      WBRNAi00031154 Inferred_automatically: RNAi_primary
      WBRNAi00045067 Inferred_automatically: RNAi_primary
      WBRNAi00013592 Inferred_automatically: RNAi_primary
      WBRNAi00115343 Inferred_automatically: RNAi_primary
      WBRNAi00001494 Inferred_automatically: RNAi_primary
      WBRNAi00013593 Inferred_automatically: RNAi_primary
      WBRNAi00045069 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr5798
      Expr9161
      Expr1024841
      Expr1031762
      Expr1149023
      Expr2014327
      Expr2032568
    Drives_construct: WBCnstr00004190
      WBCnstr00013758
      WBCnstr00035876
      WBCnstr00038180
    Construct_product: WBCnstr00035876
    Microarray_results (22)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:AVE-neuron_embryo_enriched
      WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045316:prg-1_upregulated_L4
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_tiling
      WBPaper00046121:ecdoderm_unique
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00048690:gonad-male-biased
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_4
      WBPaper00049954:BPS_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050496:unc-39(hp701)_regulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050937:lir-3(pk2183)_downregulated
      WBPaper00050990:NMDA-neuron_enriched
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot267)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADE
      WBPaper00061340:AIN_parent
      WBPaper00061340:AVH_parent
      WBPaper00061340:AVJ
      WBPaper00061340:CEP
      WBPaper00061340:DD
      WBPaper00061340:Excretory_gland
      WBPaper00061340:I1_parent
      WBPaper00061340:M1_parent
      WBPaper00061340:Neuroblast_ADE_ADA
      WBPaper00061340:Neuroblast_HSN_PHB
      WBPaper00061340:Neuroblast_URX_CEPDx
      WBPaper00061340:NSM_parent
      WBPaper00061340:PVP
      WBPaper00061340:RID_parent
      WBPaper00061340:RME
      WBPaper00061340:RME_LR_parent
      WBPaper00061340:SMB
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:176662_at-Y53F4B.16
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:sol-1-jnk-1_18695
      WBPaper00061651:AS_enriched
      WBPaper00061651:DA_enriched
      WBPaper00061651:PDB_enriched
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065841:6_2
      WBPaper00065841:6_3
      WBPaper00065841:10_0
      WBPaper00065841:14_0
      WBPaper00065841:14_2
      WBPaper00065841:32_0
      WBPaper00065841:119_0
      WBPaper00065841:132_0
      WBPaper00065841:144_0
      WBPaper00065877:rege-1(imm070)_upregulated_OP50
      cgc4386_cluster_5_1
      cgc4489_group_20
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_16
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Serratia_marcesens_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040876:mir-35_upregulated
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00042548:miRISC_enriched
      WBPaper00045673:colistin_upregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048563:L1_DD_enriched
      WBPaper00053550:daf-19(m86)_downregulated_L1
      WBPaper00057098:SiO2-nanoparticles_upregulated
    Interaction (15)
  Map_info: Map: IV Position: 5.76995 Error: 0.010598
    Positive: Positive_clone: F20B10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5514
        5519
        4583
    Pseudo_map_position
  Reference: WBPaper00013424
    WBPaper00018360
    WBPaper00019572
    WBPaper00037763
    WBPaper00038491
    WBPaper00043312
    WBPaper00055090
    WBPaper00060680
    WBPaper00062491
    WBPaper00065331
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene