WormBase Tree Display for Gene: WBGene00003670

WBGene00003670 Evidence: Paper_evidence: WBPaper00003754
  SMap: S_parent: Sequence: H10E21
  Identity: Version: 1
    Name: CGC_name: nhr-80 Person_evidence: WBPerson600
      Sequence_name: H10E21.3
      Molecular_name: H10E21.3a
        H10E21.3a.1
        CE28733
        H10E21.3b
        CE19488
        H10E21.3b.1
      Other_name: CELE_H10E21.3 Accession_evidence: NDB BX284603
      Public_name: nhr-80
    DB_info: Database: AceView gene 3A630
        WormQTL gene WBGene00003670
        WormFlux gene WBGene00003670
        NDB locus_tag CELE_H10E21.3
        Panther gene CAEEL|WormBase=WBGene00003670|UniProtKB=Q8ITW8
          family PTHR46011
        NCBI gene 175167
        RefSeq protein NM_064725.7
            NM_181901.2
        SwissProt UniProtAcc Q8ITW8
        TREEFAM TREEFAM_ID TF321941
        UniProt_GCRP UniProtAcc Q8ITW8
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nhr
    Allele: WBVar01696860
      WBVar00023138
      WBVar01696861
      WBVar01696862
      WBVar02102013
      WBVar00023143
      WBVar01696863
      WBVar01696864
      WBVar02102014
      WBVar01696865
      WBVar01696866
      WBVar02069306
      WBVar00023148
      WBVar01696867
      WBVar01696868
      WBVar00023153
      WBVar02106619
      WBVar02106620
      WBVar02106621
      WBVar02106622
      WBVar00023158
      WBVar02106623
      WBVar01500082
      WBVar02106624
      WBVar00023163
      WBVar02029718
      WBVar02029719
      WBVar02029720
      WBVar00023168
      WBVar02029721
      WBVar02029722
      WBVar00023173
      WBVar00023178
      WBVar00023183
      WBVar00023188
      WBVar00602549
      WBVar00602556
      WBVar00023193
      WBVar00023198
      WBVar00023203
      WBVar00023208
      WBVar02122114
      WBVar01397834
      WBVar00023213
      WBVar00023218
      WBVar00023223
      WBVar01767733
      WBVar01767734
      WBVar00023228
      WBVar01767735
      WBVar01767736
      WBVar01397845
      WBVar00557981
      WBVar01767737
      WBVar00557983
      WBVar01767738
      WBVar01499205
      WBVar01499941
      WBVar00557985
      WBVar01912376
      WBVar00023233
      WBVar00557986
      WBVar01767739
      WBVar01912377
      WBVar01499206
      WBVar00557988
      WBVar01767740
      WBVar01407227
      WBVar01407228
      WBVar00023238
      WBVar01767741
      WBVar00557989
      WBVar01767742
      WBVar00557990
      WBVar01767743
      WBVar00557991
      WBVar01767744
      WBVar00023243
      WBVar00557992
      WBVar01767745
      WBVar00557993
      WBVar01767746
      WBVar00557998
      WBVar02117536
      WBVar01767747
      WBVar00557999
      WBVar00023248
      WBVar02117537
      WBVar01767748
      WBVar00558001
      WBVar01577370
      WBVar01767749
      WBVar02117538
      WBVar02117539
      WBVar00023253
      WBVar01767750
      WBVar01577371
      WBVar01577372
      WBVar01577373
      WBVar00023258
      WBVar01577374
      WBVar01577375
      WBVar01577376
      WBVar01577377
      WBVar01577378
      WBVar01577379
      WBVar01577380
      WBVar01577381
      WBVar01577382
      WBVar01577383
      WBVar01498677
      WBVar01577384
      WBVar01386802
      WBVar01386806
      WBVar02100995
      WBVar01386807
      WBVar02100996
      WBVar01386809
      WBVar02100997
      WBVar01386810
      WBVar02100998
      WBVar01386812
      WBVar01961288
      WBVar01386813
      WBVar01496667
      WBVar01961289
      WBVar01961291
      WBVar01386826
      WBVar01961292
      WBVar01386832
      WBVar01386838
      WBVar01386840
      WBVar01386841
      WBVar01386842
      WBVar01386843
      WBVar01386846
      WBVar01386848
      WBVar01386849
      WBVar02147790
      WBVar02122373
      WBVar00794454
      WBVar00794455
      WBVar00794456
      WBVar00794457
      WBVar00794458
      WBVar00794459
      WBVar00794460
      WBVar01563685
      WBVar00794461
      WBVar00794462
      WBVar01563686
      WBVar01706042
      WBVar00794463
      WBVar01706043
      WBVar00794464
      WBVar00794465
      WBVar01706044
      WBVar00794466
      WBVar00387027
      WBVar01706045
      WBVar00387028
      WBVar00794467
      WBVar01706046
      WBVar00387029
      WBVar01706047
      WBVar00794468
      WBVar01706048
      WBVar00387030
      WBVar00794469
      WBVar00794470
      WBVar00387031
      WBVar01706049
      WBVar00387032
      WBVar00794471
      WBVar00387033
      WBVar00794472
      WBVar01696817
      WBVar00387034
      WBVar01696818
      WBVar00794473
      WBVar00387035
      WBVar01696819
      WBVar00794474
      WBVar01696820
      WBVar00794475
      WBVar01696821
      WBVar00794476
      WBVar01696822
      WBVar00794477
      WBVar01696823
      WBVar00598539
      WBVar00005116
      WBVar01696824
      WBVar01696825
      WBVar00250031
      WBVar01696826
      WBVar01696827
      WBVar01696828
      WBVar01696829
      WBVar01269884
      WBVar01696830
      WBVar01696831
      WBVar01696832
      WBVar01696833
      WBVar01902688
      WBVar01696834
      WBVar01696835
      WBVar01902689
      WBVar01696836
      WBVar01696837
      WBVar01696838
      WBVar01696839
      WBVar01696840
      WBVar01696841
      WBVar01696842
      WBVar01696843
      WBVar01696844
      WBVar01696845
      WBVar01696846
      WBVar01696847
      WBVar01696848
      WBVar01696849
      WBVar01950910
      WBVar01696850
      WBVar01696851
      WBVar01696852
      WBVar01696853
      WBVar01696854
      WBVar01696855
      WBVar02131292
      WBVar01696856
      WBVar01696857
      WBVar01696858
      WBVar01696859
    Strain: WBStrain00008405
      WBStrain00034506
      WBStrain00034508
      WBStrain00034509
      WBStrain00004023
      WBStrain00030244
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (30)
    Paralog (225)
    Structured_description: Concise_description: nhr-80 encodes a nuclear hormone receptor, expressed in the intestine,that regulates expression of the delta-9 desaturases FAT-5/-6/-7, andthus regulates fatty acid metabolism; NHR-80 is fully required for anyexpression of FAT-7, full expression of FAT-5/-6, viability in theabsence of FAT-6, and transcriptional hyperactivation of fat-7 in theabsence of FAT-6, and for a fully normal adult lifespan; nhr-80 isexpressed robustly in the intestine during larval and adult stages ofdevelopment, with some expression also seen in head muscles; nhr-80 isspecific to nematodes, being a divergent ortholog of HNF4 with manyparalogs in C. elegans; nhr-80(tm1011) mutants, like nhr-49 mutants,have an increased ration of saturated 18:0 fatty acids tomonounsaturated 18:1 ones (4.6 instead of 2.2); nhr-80(tm1011) mutantsare viable and fertile and have no increase in fat storage, but doublefat-6(tm331);nhr-80(tm1011) mutants, (or fat-6(tm331) mutants subjectedto nhr-80(RNAi), are synthetically lethal unless cultured on mediasupplemented with desaturated fatty acids. Paper_evidence: WBPaper00003754
            WBPaper00027749
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 12 Mar 2007 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in determination of adult lifespan; positive regulation of metabolic process; and post-embryonic development. Located in nucleus. Expressed in head; intestine; muscle cell; somatic nervous system; and tail neurons. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: H10E21.3a
      H10E21.3b
    Corresponding_transcript: H10E21.3a.1
      H10E21.3b.1
    Other_sequence (23)
    Associated_feature: WBsf650778
      WBsf226071
    Transcription_factor: WBTranscriptionFactor000724
  Experimental_info: RNAi_result (24)
    Expr_pattern: Expr1184
      Expr9203
      Expr1028389
      Expr1153088
      Expr2014232
      Expr2032473
    Drives_construct: WBCnstr00008319
      WBCnstr00010136
      WBCnstr00013793
      WBCnstr00018585
      WBCnstr00035958
    Construct_product: WBCnstr00008319
      WBCnstr00010136
      WBCnstr00013793
      WBCnstr00016839
      WBCnstr00018585
      WBCnstr00035958
    Regulate_expr_cluster: WBPaper00040998:nhr-80_regulated
    Microarray_results (24)
    Expression_cluster (97)
    Interaction (27)
    WBProcess: WBbiopr:00000121
  Map_info: Map: III Position: -27.2207 Error: 0.030731
    Positive: Positive_clone: H10E12 Inferred_automatically: From sequence, transcript, pseudogene data
        H10E21 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (37)
  Picture: WBPicture0000013097
    WBPicture0000013098
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene