| WBGene00003654 | Evidence | Paper_evidence | WBPaper00003416 |
|---|
| SMap | S_parent | Sequence | C45E1 |
| Identity | Version | 1 |
| | Name | CGC_name | nhr-64 | Person_evidence | WBPerson600 |
| | | Sequence_name | C45E1.1 |
| | | Molecular_name | C45E1.1a |
| | | | C45E1.1a.1 |
| | | | CE39696 |
| | | | C45E1.1b |
| | | | CE39697 |
| | | | C45E1.1c |
| | | | CE52156 |
| | | | C45E1.1a.2 |
| | | | C45E1.1b.1 |
| | | | C45E1.1c.1 |
| | | Other_name | CELE_C45E1.1 | Accession_evidence | NDB | BX284601 |
| | | Public_name | nhr-64 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | nhr |
| | Allele (197) |
| | Strain | WBStrain00032288 |
| | RNASeq_FPKM (74) |
| | GO_annotation (18) |
| | Ortholog (44) |
| | Paralog (42) |
| | Structured_description | Concise_description | nhr-64 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-64 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-64 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-64 in C. elegans development and/or behavior is not yet known; nhr-64 is broadly expressed and detected in anterior and posterior neurons, the ventral nerve cord, the pharynx, gut, and hypodermis. | Paper_evidence | WBPaper00006412 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in hypodermis; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 4; glucose metabolism disease (multiple); and liver disease (multiple). Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0111099 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) |
| | | DOID:13809 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) |
| | | DOID:9993 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) |
| | | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) |
| | | DOID:1686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) |
| | | DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) |
| | | DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) |
| | | DOID:0080760 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) |
| Molecular_info | Corresponding_CDS | C45E1.1a |
| | | C45E1.1b |
| | | C45E1.1c |
| | Corresponding_CDS_history | C45E1.1a:wp154 |
| | | C45E1.1b:wp154 |
| | Corresponding_transcript | C45E1.1a.1 |
| | | C45E1.1a.2 |
| | | C45E1.1b.1 |
| | | C45E1.1c.1 |
| | Other_sequence (44) |
| | Associated_feature | WBsf656104 |
| | | WBsf716912 |
| | | WBsf717472 |
| | | WBsf983060 |
| | | WBsf983061 |
| | | WBsf983062 |
| | | WBsf983063 |
| | | WBsf1009453 |
| | | WBsf1009454 |
| | | WBsf217365 |
| | Transcription_factor | WBTranscriptionFactor000193 |
| Experimental_info | RNAi_result (21) |
| | Expr_pattern | Expr2866 |
| | | Expr1017257 |
| | | Expr1031695 |
| | | Expr1146511 |
| | | Expr2014215 |
| | | Expr2032456 |
| | Drives_construct | WBCnstr00010996 |
| | Construct_product | WBCnstr00016569 |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00032425:down_in_zfp-1 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:coelomocytes_embryo_enriched |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00041222:unc-120(st364)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046338:intestine_unique |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049334:CE_intestine_enriched |
| | | WBPaper00049495:starvation-refeeding_regulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets |
| | | WBPaper00057162:meg-3_meg-4_downregulated_sRNA |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058725:sftb-1(cer39)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Parent_of_tail_spike_and_hyp10 |
| | | WBPaper00061527:bath-38-Y105E8B.7 |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066085:sin-3(tm1276)_upregulated |
| | | cgc4489_group_17 |
| | | WBPaper00025032:cluster_2 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_D |
| | | WBPaper00040184:hcf-1up_sir-2.1down_daf-2nc |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042234:xpa-1_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_4 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(83_min) |
| | Interaction (35) |
| Map_info | Map | I | Position | -4.47689 | Error | 0.002016 |
| | Positive | Positive_clone | C45E1 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4749 |
| | Pseudo_map_position |
| Reference | WBPaper00006412 |
| | WBPaper00027288 |
| | WBPaper00027309 |
| | WBPaper00036075 |
| | WBPaper00038491 |
| | WBPaper00044077 |
| | WBPaper00055090 |
| | WBPaper00059191 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
