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WormBase Tree Display for Gene: WBGene00003639

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Name Class

WBGene00003639EvidencePaper_evidenceWBPaper00003416
SMapS_parentSequenceK10C3
IdentityVersion1
NameCGC_namenhr-49Person_evidenceWBPerson600
Sequence_nameK10C3.6
Molecular_name (17)
Other_nameCELE_K10C3.6Accession_evidenceNDBBX284601
Public_namenhr-49
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnhr
Allele (78)
StrainWBStrain00031166
WBStrain00031167
WBStrain00031172
WBStrain00032408
WBStrain00034504
WBStrain00036136
WBStrain00040338
WBStrain00049816
WBStrain00051874
WBStrain00052029
RNASeq_FPKM (74)
GO_annotation (44)
Contained_in_operonCEOP1566
Ortholog (37)
Paralog (42)
Structured_descriptionConcise_descriptionnhr-49 encodes a nuclear hormone receptor (NHR) related to the mammalian HNF4 (hepatocyte nuclear factor 4) family of NHRs; nhr-49 functions as a key regulator of fat metabolism and lifespan by regulating induction of beta-oxidation genes upon food deprivation and activation of stearoyl-CoA desaturase in fed animals, respectively; NHR-49 activates transcription in conjunction with the MDT-15 mediator subunit with which it physically interacts.Paper_evidenceWBPaper00003416
WBPaper00005655
WBPaper00024532
WBPaper00025114
WBPaper00026800
WBPaper00027365
Curator_confirmedWBPerson1843
Date_last_updated17 Mar 2009 00:00:00
Automated_descriptionPredicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in determination of adult lifespan; positive regulation of transcription from RNA polymerase II promoter in response to stress; and regulation of fatty acid metabolic process. Located in cytoplasm and nucleus. Expressed in hypodermis; intestinal cell; intestine; muscle cell; and neurons. Used to study alcohol use disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 4; glucose metabolism disease (multiple); and liver disease (multiple). Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1574Homo sapiensPaper_evidenceWBPaper00041098
Curator_confirmedWBPerson324
Date_last_updated06 Jun 2019 00:00:00
DOID:9970Homo sapiensPaper_evidenceWBPaper00025114
Curator_confirmedWBPerson324
Date_last_updated20 Sep 2018 00:00:00
Potential_modelDOID:0111099Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:13809Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9993Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:1686Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:5082Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:0080760Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
Models_disease_assertedWBDOannot00000610
WBDOannot00000707
WBDOannot00000708
Molecular_infoCorresponding_CDSK10C3.6a
K10C3.6b
K10C3.6c
K10C3.6d
K10C3.6e
Corresponding_transcriptK10C3.6a.1
K10C3.6a.2
K10C3.6b.1
K10C3.6b.2
K10C3.6c.1
K10C3.6d.1
K10C3.6e.1
Other_sequence (69)
Associated_feature (15)
Transcription_factorWBTranscriptionFactor000564
Experimental_infoRNAi_result (49)
Expr_patternExpr9486
Expr10378
Expr12144
Expr16231
Expr1021226
Expr1031683
Expr1154213
Expr2014198
Expr2032439
Drives_constructWBCnstr00015289
WBCnstr00020172
WBCnstr00035977
Construct_productWBCnstr00014051
WBCnstr00016239
WBCnstr00020172
WBCnstr00021645
WBCnstr00021647
WBCnstr00035977
Regulate_expr_clusterWBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
WBPaper00061530:nhr-49(e2144)_downregulated
WBPaper00061530:nhr-49(e2144)_upregulated
Microarray_results (39)
Expression_clusterWBPaper00032528:L3_enriched
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038289:oocyte_protein
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040221:DAF-12_target_ALF4
WBPaper00041222:unc-120(st364)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045316:prg-1_upregulated_L4
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Oogenic
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050182:lmn-1(L535P)_upregulated
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:nucleus_specific
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053615:SMO-1_target
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055648:germline_expressed
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00057288:iff-1(RNAi)_upregulated_transcript
WBPaper00058691:CFP-1_interacting_protein
WBPaper00058691:set-2(bn129)_downregulated
WBPaper00058691:WDR-5.1_interacting_protein
WBPaper00058725:sftb-1(cer39)_downregulated
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00059763:neuron_expressed
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061340:CEPso
WBPaper00061340:g1A_g1P
WBPaper00061340:g1A_parent
WBPaper00061340:ILsh_OLLsh_OLQsh
WBPaper00061340:ILso
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:ldb-1_2877-scd-1_3086
WBPaper00061527:pkn-1_20439-tbc-12_11015
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062590:Aging_downregulated_hypodermis
WBPaper00064071:NHR-49_interacting
WBPaper00064565:dyf-1(mn335)_regulated_protein
WBPaper00064716:paraquat_upregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065158:AFD_depleted
WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
cgc4386_cluster_5_2
WBPaper00025032:cluster_189
WBPaper00025141:N2_Expressed_Genes
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00034739:N2moreDR1350
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035905:FBF-1_Associated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-exposed_3h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:cluster_91
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(41_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
SAGE_tag (12)
Interaction (374)
WBProcessWBbiopr:00000001
WBbiopr:00000121
Map_infoMapIPosition3.96404Error0.005389
PositivePositive_cloneK10C3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5149
4447
Pseudo_map_position
Reference (157)
PictureWBPicture0000013096
WBPicture0000013097
WBPicture0000013098
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene