WormBase Tree Display for Gene: WBGene00003573

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WBGene00003573	Evidence	Author_evidence	Schwartz EM
	SMap	S_parent	Sequence	C13D9
	Identity	Version	1
		Name	CGC_name	ncx-8
			Sequence_name	C13D9.7
			Molecular_name	C13D9.7
				C13D9.7.1
				CE08140
			Other_name	CELE_C13D9.7	Accession_evidence	NDB	BX284605
			Public_name	ncx-8
		DB_info	Database	AceView	gene	5F462
				WormQTL	gene	WBGene00003573
				WormFlux	gene	WBGene00003573
				NDB	locus_tag	CELE_C13D9.7
				Panther	gene	CAEEL\|WormBase=WBGene00003573\|UniProtKB=O16241
					family	PTHR12266
				NCBI	gene	182575
				RefSeq	protein	NM_071940.7
				TREEFAM	TREEFAM_ID	TF323444
				TrEMBL	UniProtAcc	O16241
				UniProt_GCRP	UniProtAcc	O16241
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:32	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	ncx
		Allele (190)
		RNASeq_FPKM (74)
		GO_annotation (11)
		Ortholog (47)
		Paralog	WBGene00003571	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00003572	Caenorhabditis elegans	From_analysis	TreeFam
						Inparanoid_8
						Panther
						WormBase-Compara
			WBGene00003574	Caenorhabditis elegans	From_analysis	TreeFam
						Inparanoid_8
						Panther
						WormBase-Compara
			WBGene00003575	Caenorhabditis elegans	From_analysis	TreeFam
						Inparanoid_8
						Panther
						WormBase-Compara
		Structured_description	Concise_description	ncx-8 encodes a putative Na[+]/Ca[2+] exchanger of uncertainstoichiometry and affinity, orthologous to human SLC24A6 and paralogousto NCX-6/-7 and NCX-9/-10; NCX-8 may function intracellularly; NCX-8 has tandem Calx-alpha domains predicted to carry out ion transport; NCX-8 is required for normally high levels of body fat.	Paper_evidence	WBPaper00012774
						WBPaper00028596
						WBPaper00031156
						WBPaper00031157
						WBPaper00031158
						WBPaper00031159
						WBPaper00031160
					Curator_confirmed	WBPerson567
					Date_last_updated	07 Nov 2007 00:00:00
			Automated_description	Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be located in membrane. Expressed in intestine and pharynx. Is an ortholog of human SLC8B1 (solute carrier family 8 member B1).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	C13D9.7
		Corresponding_transcript	C13D9.7.1
		Other_sequence	CR11255
		Associated_feature	WBsf233628
			WBsf233629
	Experimental_info	RNAi_result	WBRNAi00023936	Inferred_automatically	RNAi_primary
			WBRNAi00010691	Inferred_automatically	RNAi_primary
			WBRNAi00112438	Inferred_automatically	RNAi_primary
			WBRNAi00023136	Inferred_automatically	RNAi_primary
			WBRNAi00040442	Inferred_automatically	RNAi_primary
			WBRNAi00023648	Inferred_automatically	RNAi_primary
			WBRNAi00023043	Inferred_automatically	RNAi_primary
			WBRNAi00112439	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr11162
			Expr1025533
			Expr1144509
			Expr2013925
			Expr2032164
		Drives_construct	WBCnstr00018022
			WBCnstr00036032
		Construct_product	WBCnstr00036032
		Microarray_results (19)
		Expression_cluster	WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
			WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
			WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
			WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
			WBPaper00040560:hpl-2_L3_upregulated
			WBPaper00042561:smgl-1(RNAi)_upregulated
			WBPaper00044578:reduced-humidity_downregulated_microarray
			WBPaper00044736:oscillating_dev_expression
			WBPaper00045390:ubc-9(RNAi)_upregulated
			WBPaper00045420:fertilization_downregulated_transcript
			WBPaper00045934:wrn-1(gk99)_upregulated
			WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
			WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
			WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
			WBPaper00048971:daf-16(mgDf50)_upregulated_L1
			WBPaper00048988:neuron_expressed
			WBPaper00049545:cco-1(RNAi)_upregulated
			WBPaper00049545:jmjd-3.1(+)_upregulated
			WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
			WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
			WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
			WBPaper00050080:rbr-2(tm3141)_downregulated
			WBPaper00050163:let-418(RNAi)_upregulated_24-cell-embryo
			WBPaper00050193:cec-4(ok3124)_upregulated_L1
			WBPaper00050370:dpy-21(e428)_L3_upregulated
			WBPaper00050412:cco-1(RNAi)_upregulated_N2
			WBPaper00050726:OsmoticStress_regulated_Food
			WBPaper00050726:OsmoticStress_regulated_NoFood
			WBPaper00053184:sma-2(rax5)_upregulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053295:lin-22(icb38)_upregulated
			WBPaper00053388:dauer_regulated_Cluster3
			WBPaper00053402:cco-1(RNAi)_upregulated
			WBPaper00053402:his-3(RNAi)_upregulated
			WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
			WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
			WBPaper00053810:isp-1(qm150)_upregulated
			WBPaper00055013:hmg-3(bar24)_upregulated
			WBPaper00055354:eat-2(ad1116)_upregulated
			WBPaper00055354:Rapamycin-Allantoin_upregulated
			WBPaper00055354:Rapamycin_upregulated
			WBPaper00055354:Rifampicin-Allantoin_upregulated
			WBPaper00055482:Tunicamycin_downregulated
			WBPaper00055648:nerve-ring_expressed
			WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
			WBPaper00056617:adr-1_upregulated_L4_transcript
			WBPaper00057068:numr-1(RNAi)_downregulated
			WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
			WBPaper00057288:Cold_upregulated_transcript
			WBPaper00058598:mex-1(or286)_upregulated
			WBPaper00058598:mex-3(eu149)_upregulated
			WBPaper00058678:DAF-12_downregulated_PVD
			WBPaper00058691:sin-3(tm1276)_upregulated
			WBPaper00058725:sftb-1(cer6)_downregulated
			WBPaper00058725:sftb-1(cer39)_downregulated
			WBPaper00058948:npr-8(ok1439)_downregulated_PA14
			WBPaper00058969:RIS_depleted
			WBPaper00059191:hsp-16.2p-LIN-29_downregulated
			WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
			WBPaper00059537:ngn-1(ok2200)_upregulated
			WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
			WBPaper00060014:set-2(zr2012)_downregulated
			WBPaper00060100:SiNP_upregulated_mRNA
			WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
			WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
			WBPaper00060445:nfki-1(cer1)_upregulated_L4
			WBPaper00060661:sensory-neuron_depleted
			WBPaper00060909:atfs-1(cmh15)_downregulated
			WBPaper00060909:atfs-1(et18)_downregulated
			WBPaper00061040:eat-2(ad1116)_upregulated
			WBPaper00061340:hyp3
			WBPaper00061340:XXX
			WBPaper00061341:28C_24h_upregulated
			WBPaper00061341:28C_48h_upregulated
			WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
			WBPaper00061479:hda-1(ne4752)_upregulated
			WBPaper00061479:ubc-9(ne4833)_upregulated
			WBPaper00061527:col-128-cdh-10_9234
			WBPaper00061753:csr-1(tor159)_upregulated_20C
			WBPaper00062159:hda-2(ok1479)_upregulated
			WBPaper00062325:muscle_depleted_coding-RNA
			WBPaper00062345:bortezomib_4h_downregulated_N2
			WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
			WBPaper00062440:crh-1(n3315)_upregulated
			WBPaper00062446:nhr-8(hd117)_upregulated
			WBPaper00062672:let-418(n3536)_upregulated
			WBPaper00064509:static-magnetic-field_upregulated
			WBPaper00064769:him-17(me24)_upregulated
			WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
			WBPaper00065029:cadmium_downregulated
			WBPaper00065096:Day10_vs_Day1_upregulated
			WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
			WBPaper00065158:AFD_depleted
			WBPaper00065258:anchor-cell_depleted
			WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
			WBPaper00065749:Heat-Shock_downregulated_N2
			WBPaper00065841:9_1
			WBPaper00065841:9_2
			WBPaper00065841:15_0
			WBPaper00065841:24_0
			WBPaper00065841:26_0
			WBPaper00065841:26_1
			WBPaper00065984:pals-17(syb3980)_upregulated
			WBPaper00065993:glp-1(e2141)_upregulated
			WBPaper00066062:xrep-4(lax137)_upregulated
			cgc4489_group_5
			WBPaper00026929:Resveratrol_regulated_daf-16
			WBPaper00026952:class_B
			WBPaper00030985:Erwinia_carotovora_upregulated
			WBPaper00031003:24hr_muscle_enriched
			WBPaper00031003:total_muscle_enriched
			WBPaper00034739:N2lessDR1350
			WBPaper00036286:Pattern_G
			WBPaper00038172:aak-2overexpression_down_regulated
			WBPaper00038172:crh-1null_up_regulated
			WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
			WBPaper00040858:eQTL_age_regulated_developing
			WBPaper00040858:eQTL_regulated_developing
			WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
			WBPaper00045673:colistin_downregulated
			WBPaper00045960:L1-L4-lethargus_downregulated
			WBPaper00045960:L4-lethargus_downregulated
			WBPaper00047070:N2_UV_upregulated
		Interaction (32)
	Map_info	Map	V	Position	-3.61451	Error	0.002001
		Positive	Positive_clone	C13D9	Inferred_automatically	From CDS info
						From sequence, transcript, pseudogene data
		Pseudo_map_position
	Reference	WBPaper00038491
		WBPaper00055090
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene