WormBase Tree Display for Gene: WBGene00003518

WBGene00003518 Evidence: Paper_evidence: WBPaper00013356
    CGC_data_submission
  SMap: S_parent: Sequence: R107
  Identity: Version: 1
    Name: CGC_name: nac-2
      Sequence_name: R107.1
      Molecular_name: R107.1a
        R107.1a.1
        CE33536
        R107.1b
        CE47161
        R107.1b.1
      Other_name: nat-1 CGC_data_submission
        indy-3 Accession_evidence: EMBL AY090486
        C. elegans NaCT Paper_evidence: WBPaper00046369
        CELE_R107.1 Accession_evidence: NDB BX284603
      Public_name: nac-2
    DB_info: Database: AceView gene 3K130
        WormQTL gene WBGene00003518
        WormFlux gene WBGene00003518
        NDB locus_tag CELE_R107.1
        Panther gene CAEEL|WormBase=WBGene00003518|UniProtKB=P32739
          family PTHR10283
        NCBI gene 187898
        RefSeq protein NM_001268048.2
            NM_001268047.2
        SwissProt UniProtAcc P32739
        TrEMBL UniProtAcc H9G2P8
        UniProt_GCRP UniProtAcc P32739
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nac
    Allele (55)
    Strain: WBStrain00032294
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog: WBGene00055261 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00029030 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00137039 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00191305 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      CBOVI.g4343 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g14795 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g9601 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g20148 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g3363 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g4401 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g2194 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g3284 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g794 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g12688 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00030.g1746 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-nac-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g15113 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00298.g8940 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_18933 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_009255 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g03524 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04966 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g05026 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g11069 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g16453 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g7274 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30257800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g8532 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00181857 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00266835 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00292597 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000000633 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            SonicParanoid
      SGD:S000003734 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            SonicParanoid
      SGD:S000005296 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            SonicParanoid
      FB:FBgn0032314 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      FB:FBgn0064119 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-031222-3 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-040426-2486 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-040426-2389 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-030131-4628 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-130530-605 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-070424-71 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      HGNC:10917 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      MGI:1276558 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      MGI:1859937 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      MGI:2149635 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      MGI:3037150 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      MGI:2442367 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      RGD:61919 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      RGD:628786 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      RGD:61920 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      RGD:631374 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
    Paralog: WBGene00003517 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003519 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007138 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: nac-2 encodes a high affinity sodium-coupled citrate transporter that is orthologous to the mammalian citrate transporter NaCT and is one of four C. elegans proteins related to Drosophila Indy; when expressed in a heterologous system, NAC-2 exhibits high affinity sodium/citrate and sodium/succinate cotransporter activity, although the transport rate for citrate is much higher than that for succinate; nac-2::gfp reporter fusions are expressed in the intestine, from early larval stages through adulthood; the effects of nac-2(RNAi) are variable, with reports of a 19% increase in lifespan accompanied by decreased body size and fat content in affected animals and reports of no apparent decrease in average lifespan. Paper_evidence: WBPaper00006504
            WBPaper00030797
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Jun 2007 00:00:00
      Automated_description: Enables citrate transmembrane transporter activity and succinate transmembrane transporter activity. Involved in several processes, including carboxylic acid transport; determination of adult lifespan; and regulation of growth. Predicted to be located in membrane. Expressed in rect_D; rect_VL; and rect_VR. Is an ortholog of human SLC13A2 (solute carrier family 13 member 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: R107.1a
      R107.1b
    Corresponding_CDS_history: R107.1:wp96
    Corresponding_transcript: R107.1a.1
      R107.1b.1
    Other_sequence: EX563221.1
      Oden_isotig23345
      ACC20218_1
      Oden_isotig23736
    Associated_feature: WBsf216753
      WBsf651331
      WBsf993556
      WBsf227227
  Experimental_info: RNAi_result: WBRNAi00066314 Inferred_automatically: RNAi_primary
      WBRNAi00051667 Inferred_automatically: RNAi_primary
      WBRNAi00034804 Inferred_automatically: RNAi_primary
      WBRNAi00005487 Inferred_automatically: RNAi_primary
      WBRNAi00061326 Inferred_automatically: RNAi_primary
      WBRNAi00017683 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2725
      Expr2978
      Expr1012678
      Expr1031612
      Expr1155341
      Expr2013853
      Expr2032093
    Drives_construct: WBCnstr00000581
      WBCnstr00010920
      WBCnstr00011057
      WBCnstr00036076
    Construct_product: WBCnstr00036076
    Microarray_results (20)
    Expression_cluster (149)
    Interaction: WBInteraction000030455
      WBInteraction000225197
      WBInteraction000285570
      WBInteraction000285571
      WBInteraction000424798
      WBInteraction000425619
      WBInteraction000473287
      WBInteraction000501615
      WBInteraction000504104
  Map_info: Map: III Position: 0.106568 Error: 0.006891
    Positive: Positive_clone: R107 Inferred_automatically: From sequence, transcript, pseudogene data
            From CDS info
    Mapping_data: Multi_point: 4835
        4799
        4764
        5517
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene