WormBase Tree Display for Gene: WBGene00003469

WBGene00003469 SMap: S_parent: Sequence: K05F1
  Identity: Version: 1
    Name: CGC_name: msp-142 Person_evidence: WBPerson680
      Sequence_name: K05F1.2
      Molecular_name: K05F1.2
        K05F1.2.1
        CE02806
      Other_name: CELE_K05F1.2 Accession_evidence: NDB BX284602
      Public_name: msp-142
    DB_info: Database: AceView gene 2G89
        WormQTL gene WBGene00003469
        WormFlux gene WBGene00003469
        NDB locus_tag CELE_K05F1.2
        NCBI gene 173981
        RefSeq protein NM_062743.6
        SwissProt UniProtAcc P53017
        UniProt_GCRP UniProtAcc P53017
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: msp
    Allele (14)
    Legacy_information: Cluster of two genes four pseudogenes including msp-142 (transcribed).
      [C.elegansII] NMK. Encodes MSP (16kD). Defines cluster of two genes, four pseudogenes including msp-142 (transcribed). [Ward et al. (1988); BA]
    RNASeq_FPKM (74)
    Ortholog (34)
    Paralog (49)
    Structured_description: Concise_description: msp-142 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence: WBPaper00001023
            WBPaper00002143
            WBPaper00004591
            WBPaper00005670
          Curator_confirmed: WBPerson324
          Date_last_updated: 31 Mar 2005 00:00:00
      Automated_description: Expressed in gonad; oocyte; and sperm. Is predicted to encode a protein with the following domains: Major sperm protein (MSP) domain; MSP (Major sperm protein) domain; PapD-like superfamily; and Immunoglobulin-like fold. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K05F1.2
    Corresponding_transcript: K05F1.2.1
    Other_sequence (355)
    Associated_feature: WBsf221344
  Experimental_info: RNAi_result: WBRNAi00033989 Inferred_automatically: RNAi_primary
      WBRNAi00049989 Inferred_automatically: RNAi_primary
      WBRNAi00059194 Inferred_automatically: RNAi_primary
      WBRNAi00021849 Inferred_automatically: RNAi_primary
      WBRNAi00059192 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3417
      Expr1022410
      Expr1153684
      Expr2013770
      Expr2032006
    Drives_construct: WBCnstr00036098
    Construct_product: WBCnstr00005246
      WBCnstr00022850
      WBCnstr00036098
    Antibody: WBAntibody00000037
      WBAntibody00000038
      WBAntibody00000854
      WBAntibody00000855
      WBAntibody00000856
      WBAntibody00000857
      WBAntibody00000858
    Microarray_results (15)
    Expression_cluster: WBPaper00027339:daf-12(rh273)_upregulated
      WBPaper00029047:atx-3_upregulated
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00035211:age-1_vs_age-1_upregulated
      WBPaper00036231:long-telomeres_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_downregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00040412:germline-regulated_daf-12_target
      WBPaper00040560:hpl-2_L3_downregulated
      WBPaper00041071:spe-44_downregulated
      WBPaper00041954:ethanol_upregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00043945:MeHg_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044616:alg-3-4_downregulated_gene
      WBPaper00044736:rising_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00045303:ZK1236.1(tm4178)_upregulated
      WBPaper00045316:prg-1_upregulated_L1
      WBPaper00045521:Spermatogenic
      WBPaper00045622:DR1345_vs_SR708_regulated
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:csr-1(RNAi)_upregulated_Set2
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00046805:P-granule-RNAi_upregulated_Set2
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049489:AMsh-glia_enriched
      WBPaper00049498:npr-1(ur89)_regulated_2
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPA_downregulated
      WBPaper00049954:BPS_downregulated
      WBPaper00050231:male_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051265:F1_hrde-1(tm1200)_upregulated
      WBPaper00051265:F1_morc-1(tm6048)_upregulated
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00054410:set-9(rw5)_downregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055648:sperm_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:ptl-1(ok621)_downregulated
      WBPaper00056039:ptrn-1(tm5597)_downregulated
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:flcn-1(ok975)_downregulated
      WBPaper00056586:kri-1(ok1251)_upregulated
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00057347:nhr-14(tm1473)_upreglated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_upregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059426:Ag-nanoparticles_upregulated
      WBPaper00059426:SiO2-nanoparticles_upregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060526:plp-1(ok2155)_upregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060744:Radiation_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060911:prx-5(RNAi)_downregulated_mRNA
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tbh-1(ok1196)_downregulated
      WBPaper00061040:eat-2(ad1116)_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061479:hda-1(ne4747)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:msp-63-msp-33
      WBPaper00061572:oleic-acid-specific_mating_upregulated
      WBPaper00061651:Sperm_enriched
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00062590:Aging_downregulated_body-wall-muscle
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064232:amdh-1(uth29)_downregulated
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_upregulated_starved
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
      WBPaper00065158:25C_vs_15C_downregulated_AFD
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065578:gcn-1(nc40)_upregulated
      WBPaper00065734:unc-25(e156)_downregulated
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065841:3_3
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4386_cluster_1_1
      cgc4489_group_11
      WBPaper00025099:MA_specific
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00031184:acrylamide_upregulated
      WBPaper00033101:spr-5_regulated
      WBPaper00036286:Pattern_E
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00037113:CPF_DZN_16C_down-regulated
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00042236:flcn-1(ok975)_upregulated
      WBPaper00045673:colistin_downregulated
      WBPaper00051387:Triclosan_downregulated
      [cgc6390]:Cluster_D
      [cgc6390]:spermatogenesis-enriched
    Interaction (200)
  Map_info: Map: II Position: -0.923359 Error: 0.001298
    Positive: Positive_clone: BA#62
        K05F1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00001023
    WBPaper00001024
    WBPaper00001209
    WBPaper00003113
    WBPaper00004591
    WBPaper00015440
    WBPaper00024312
    WBPaper00032220
    WBPaper00064850
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene