| WBGene00003417 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | Y41C4A |
| Identity | Version | 1 |
| | Name | CGC_name | mrt-2 | Person_evidence | WBPerson261 |
| | | Sequence_name | Y41C4A.14 |
| | | Molecular_name | Y41C4A.14 |
| | | | Y41C4A.14.1 |
| | | | CE29376 |
| | | | Y41C4A.14.2 |
| | | Other_name | hpr-1 |
| | | | CELE_Y41C4A.14 | Accession_evidence | NDB | BX284603 |
| | | Public_name | mrt-2 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mrt |
| | Allele (132) |
| | Strain | WBStrain00031909 |
| | | WBStrain00004639 |
| | RNASeq_FPKM (74) |
| | GO_annotation (26) |
| | Ortholog (34) |
| | Structured_description | Concise_description | mrt-2 encodes a highly conserved DNA-damage checkpoint protein homologous to the RAD1 protein found in S. pombe, Drosophila, and mammals; mrt-2 functions in the germline to maintain chromosomal integrity, and promote cell cycle arrest in mitotic germ cells and apoptosis in meiotic germ cells in response to genotoxic agents (DNA damage); mrt-2 mutations result in progressive telomere loss, chromosome fusion, and aneuploidy, eventually leading to germline mortality; MRT-2 interacts with HUS-1 and HPR-9, also conserved DNA-damage checkpoint proteins. | Paper_evidence | WBPaper00003353 |
| | | | | | WBPaper00003886 |
| | | | | | WBPaper00003984 |
| | | | | | WBPaper00005237 |
| | | | | | WBPaper00005597 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 14 Jun 2011 00:00:00 |
| | | Automated_description | Predicted to enable 3'-5' exonuclease activity and damaged DNA binding activity. Involved in DNA damage response and telomere maintenance via telomerase. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Is an ortholog of human RAD1 (RAD1 checkpoint DNA exonuclease). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | Y41C4A.14 |
| | Corresponding_transcript | Y41C4A.14.1 |
| | | Y41C4A.14.2 |
| | Other_sequence | JI459899.1 |
| | | CBC00612_1 |
| | | CR07641 |
| | | HG06632 |
| | | EY472449.1 |
| | | GP01754 |
| | | OF00726 |
| | | GE638976.1 |
| | | HCC04778_1 |
| | | MA03330 |
| | Associated_feature | WBsf994482 |
| | | WBsf225855 |
| Experimental_info | RNAi_result | WBRNAi00064153 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00022481 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00006768 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00064152 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00067556 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00064105 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00056356 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027845 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1016257 |
| | | Expr1031584 |
| | | Expr1159841 |
| | | Expr2013762 |
| | | Expr2031997 |
| | Drives_construct | WBCnstr00005145 |
| | Construct_product | WBCnstr00005145 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040560:hpl-2_embryo_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:daf-2(e1370)_downregulated_neuron |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00059566:P.luminescens_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061340:URX |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:kle-2_4298-vrk-1 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066038:mip-1(how5)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025032:cluster_4 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030985:Photorhabdus_luminescens_downregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_5 |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035479:daf-16(RNAi)_upregulated |
| | | WBPaper00035560:ahr-1_downregulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_3 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | Interaction (197) |
| | WBProcess | WBbiopr:00000014 |
| | | WBbiopr:00000091 |
| Map_info | Map | III | Position | 12.0743 | Error | 0.051368 |
| | Positive | Positive_clone | Y41C4A | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4239 |
| | | | 4497 |
| | Pseudo_map_position |
| Reference (76) |
| Picture | WBPicture0000013091 |
| Remark | Sequence connection from [Ahmed S, Hodgkin J] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
