WormBase Tree Display for Gene: WBGene00003395
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| WBGene00003395 | SMap | S_parent | Sequence | F38E1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mom-2 | Person_evidence | WBPerson498 | |||||
| Sequence_name | F38E1.7 | ||||||||
| Molecular_name | F38E1.7 | ||||||||
| F38E1.7.1 | |||||||||
| CE17806 | |||||||||
| Other_name | CELE_F38E1.7 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | mom-2 | ||||||||
| DB_info | Database | AceView | gene | 5I837 | |||||
| WormQTL | gene | WBGene00003395 | |||||||
| SignaLink | protein | WBGene00003395 | |||||||
| WormFlux | gene | WBGene00003395 | |||||||
| NDB | locus_tag | CELE_F38E1.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003395|UniProtKB=Q10459 | |||||||
| family | PTHR12027 | ||||||||
| NCBI | gene | 179217 | |||||||
| RefSeq | protein | NM_072753.7 | |||||||
| SwissProt | UniProtAcc | Q10459 | |||||||
| UniProt_GCRP | UniProtAcc | Q10459 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mom | ||||||||
| Allele (43) | |||||||||
| Possibly_affected_by | WBVar02153195 | ||||||||
| Legacy_information | Maternal effect embryonic lethal. The E blastomere fails to make intestinal cells and instead makes pharyngeal and muscle tissue, like MS (mom=MOre Mesoderm). Embryos undergo little morphogenesis. The cleavage plane of ABar is altered. | ||||||||
| [Rocheleau CE] ne141 is a Tc1 insertion: homozygotes are Mel, producing embryos that lack endoderm, overproduce pharyngeal tissue. mom-2 encodes a Wnt related protein, predicted gene F38E1.7 | |||||||||
| Complementation_data | [Thorpe C] Complements skn-2(zu148), let-433(s950), let-464(s1504) | ||||||||
| Strain (15) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (45) | |||||||||
| Ortholog (31) | |||||||||
| Paralog | WBGene00000857 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000858 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001188 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003029 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mom-2 encodes a member of the Wnt family of secreted signaling glycoproteins that is required for induction of endodermal (gut) tissue in the 4-cell stage embryo; MOM-2, required in the inducing blastomere (P2) at the 4-cell stage, may be the ligand for MOM-5, a Frizzled homolog, thought to act in the receiving blastomere (EMS); MOM-2 genetically interacts in the same pathway as KIN-19, but parallel to APR-1; MOM-2 also may be a ligand for LIN-18, a Ryk homolog. | Paper_evidence | WBPaper00002870 | |||||
| WBPaper00003768 | |||||||||
| WBPaper00017211 | |||||||||
| WBPaper00022765 | |||||||||
| WBPaper00024383 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 11 Apr 2005 00:00:00 | ||||||||
| Automated_description | Enables receptor tyrosine kinase binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; embryonic morphogenesis; and neuron migration. Predicted to be located in extracellular space. Expressed in several structures, including HSN; P5.ppp; P7.paa; anchor cell; and epithelial cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F38E1.7 | |||||||
| Corresponding_transcript | F38E1.7.1 | ||||||||
| Other_sequence (31) | |||||||||
| Associated_feature | WBsf646999 | ||||||||
| WBsf661057 | |||||||||
| WBsf661475 | |||||||||
| WBsf661476 | |||||||||
| WBsf1000635 | |||||||||
| WBsf1000636 | |||||||||
| WBsf232098 | |||||||||
| Experimental_info | RNAi_result (152) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00011101 | ||||||||
| WBCnstr00013049 | |||||||||
| WBCnstr00018200 | |||||||||
| WBCnstr00019092 | |||||||||
| WBCnstr00020126 | |||||||||
| WBCnstr00036141 | |||||||||
| WBCnstr00042483 | |||||||||
| Construct_product | WBCnstr00016619 | ||||||||
| WBCnstr00036141 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (208) | |||||||||
| Interaction (349) | |||||||||
| Anatomy_function | WBbtf0746 | ||||||||
| WBProcess | WBbiopr:00000023 | ||||||||
| WBbiopr:00000073 | |||||||||
| WBbiopr:00000112 | |||||||||
| Map_info | Map | V | Position | 1.32369 | Error | 0.00238 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F38E1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| ZK427 | |||||||||
| Negative | Negative_clone | F52E1 | |||||||
| Mapping_data | 2_point | 7071 | |||||||
| Multi_point | 3507 | ||||||||
| 3508 | |||||||||
| 3634 | |||||||||
| 4093 | |||||||||
| 4368 | |||||||||
| Reference (156) | |||||||||
| Picture | WBPicture0000013084 | ||||||||
| Remark | Data extracted from Rocheleau et al. (1997) | ||||||||
| Method | Gene |
