WormBase Tree Display for Gene: WBGene00000858
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| WBGene00000858 | SMap | S_parent | Sequence | W01B6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cwn-2 | Person_evidence | WBPerson1157 | |||||
| Sequence_name | W01B6.1 | ||||||||
| Molecular_name | W01B6.1 | ||||||||
| W01B6.1.1 | |||||||||
| CE03753 | |||||||||
| Other_name | Wnt-2 | ||||||||
| CELE_W01B6.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | cwn-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cwn | ||||||||
| Allele (30) | |||||||||
| Legacy_information | [C.elegansII] NMK. 1.5 kb transcript, most abundant in embryo, encodes predicted 362 aa Wnt homolog. [Shackleford et al. 1993; CF] | ||||||||
| [Shivakumar S, Jongeward G] C. elegans wnt homolog. originally isolated as cm9h7. Accession number cwn-2 mRNA X72943 | |||||||||
| Strain (21) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (66) | |||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00000857 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003029 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001188 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003395 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cwn-2 encodes one of five C. elegans Wnt signaling molecules that is homologous to mammalian Wnt5; cwn-2 is required for proper placement of the nerve ring and anterior cells along the anterior/posterior axis; cwn-2 also acts redundantly to specify cell fates during vulval development; CWN-2 appears to be required at the time of nerve ring development (comma stage of embryogenesis) for nerve ring placement and likely functions as a signaling ligand for receptors, such as CAM-1, that regulate axon guidance of the SIA and SIB neurons that plays a role in nerve ring placement; CWN-2, along with LIN-17, CAM-1, and DSH-1, functions as part of a Wnt signaling pathway that regulates ACR-16 localization to postsynaptic regions, a key component of activity-dependent synaptic plasticity; in embryos at the comma stage, a cwn-2::gfp reporter is expressed in the intestine and in pharyngeal muscle; in larvae and adults, cwn-2::gfp is seen in the intestine, pharynx, anterior body wall muscle, vulva and SMD head neurons. | Paper_evidence | WBPaper00024383 | |||||
| WBPaper00027140 | |||||||||
| WBPaper00028436 | |||||||||
| WBPaper00035405 | |||||||||
| WBPaper00040939 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 17 Apr 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable cytokine activity and frizzled binding activity. Involved in several processes, including neuroblast migration; neuron migration; and pattern specification process. Predicted to be located in extracellular space. Expressed in several structures, including P5.ppp; P7.paa; RME; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant Robinow syndrome 1; endometrial carcinoma; and germ cell cancer (multiple). Is an ortholog of human WNT5A (Wnt family member 5A) and WNT5B (Wnt family member 5B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12784) | ||||
| DOID:1911 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12781) | ||||||
| DOID:0060766 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12784) | ||||||
| DOID:3307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12781) | ||||||
| DOID:127 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16265) | ||||||
| DOID:0060774 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12781) | ||||||
| Molecular_info | Corresponding_CDS | W01B6.1 | |||||||
| Corresponding_transcript | W01B6.1.1 | ||||||||
| Other_sequence (34) | |||||||||
| Associated_feature | WBsf660548 | ||||||||
| WBsf997547 | |||||||||
| WBsf997548 | |||||||||
| WBsf1018041 | |||||||||
| WBsf1018042 | |||||||||
| WBsf228924 | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern (16) | |||||||||
| Drives_construct (16) | |||||||||
| Construct_product (15) | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (144) | |||||||||
| Interaction (134) | |||||||||
| Anatomy_function | WBbtf0799 | ||||||||
| WBbtf0800 | |||||||||
| WBbtf0801 | |||||||||
| WBProcess | WBbiopr:00000023 | ||||||||
| WBbiopr:00000073 | |||||||||
| Map_info | Map | IV | Position | 4.48175 | Error | 0.001015 | |||
| Positive | Positive_clone | B0555 | |||||||
| W01B6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Pseudo_map_position | |||||||||
| Reference (80) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
