| WBGene00003243 | SMap | S_parent | Sequence | F10E9 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | mig-10 | Person_evidence | WBPerson261 |
| | | Sequence_name | F10E9.6 |
| | | Molecular_name (11) |
| | | Other_name | CELE_F10E9.6 | Accession_evidence | NDB | BX284603 |
| | | Public_name | mig-10 |
| | DB_info | Database | AceView | gene | 3J395 |
| | | | WormQTL | gene | WBGene00003243 |
| | | | WormFlux | gene | WBGene00003243 |
| | | | NDB | locus_tag | CELE_F10E9.6 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00003243|UniProtKB=P34400 |
| | | | | family | PTHR11243 |
| | | | NCBI | gene | 176168 |
| | | | RefSeq | protein | NM_001379826.1 |
| | | | | | NM_066420.6 |
| | | | | | NM_001382935.2 |
| | | | SwissProt | UniProtAcc | P34400 |
| | | | TREEFAM | TREEFAM_ID | TF317511 |
| | | | UniProt_GCRP | UniProtAcc | P34400 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mig |
| | Allele (291) |
| | Possibly_affected_by | WBVar02157219 |
| | Legacy_information | [C.elegansII] ct41 : incomplete CAN, HSN, ALM migrations; shortened excretory canals; additional defects. Mosaic analysis indicates non-autonomy, possible hypodermal focus. OA1: e2527. Cloned: encodes predicted 650 aa protein with similarity to human Grb7, Grb10, including pleckstrin homology domain. [Desai et al. 1988; LK] |
| | Strain | WBStrain00001485 |
| | | WBStrain00002915 |
| | | WBStrain00003479 |
| | | WBStrain00033874 |
| | | WBStrain00032605 |
| | | WBStrain00003959 |
| | | WBStrain00051958 |
| | RNASeq_FPKM (74) |
| | GO_annotation (27) |
| | Ortholog (38) |
| | Structured_description | Concise_description | mig-10 encodes proteins that contain, from N- to C-terminus, an RA-like (Ras association) domain, a PH (pleckstrin homology) domain, and a proline-rich motif, and that are homologous to the vertebrate RIAM, lamellopodin, and Grb7, Grb10, and Grb14 cytoplasmic adaptor proteins; during development, mig-10 activity is required for cell migration and for outgrowth of axons and excretory cell canals; in regulating axon outgrowth, MIG-10 likely functions downstream of UNC-6/Netrin and SLT-1/Slit and in concert with UNC-34, with which it interacts in vitro; MIG-10 also physically interacts with ABI-1 (Abelson interactor-1); mig-10::gfp reporter fusions are expressed in neurons as well as in pharyngeal and intestinal tissue; when expressed in tissue culture cells, a MIG-10::GFP fusion protein colocalizes with F-actin and promotes lamellipodia formation. | Paper_evidence | WBPaper00001304 |
| | | | | | WBPaper00002766 |
| | | | | | WBPaper00027185 |
| | | | | | WBPaper00027328 |
| | | | | | WBPaper00041596 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 13 Nov 2012 00:00:00 |
| | | Automated_description | Enables SH3 domain binding activity. Involved in several processes, including cell migration; cell projection organization; and egg-laying behavior. Located in neuronal cell body membrane; plasma membrane bounded cell projection; and presynaptic cytosol. Part of filamentous actin. Expressed in hermaphrodite gonad; neurons; and tail. Is an ortholog of human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F10E9.6a |
| | | F10E9.6b |
| | | F10E9.6c |
| | Corresponding_CDS_history | F10E9.6a:wp113 |
| | | F10E9.6b:wp113 |
| | Corresponding_transcript | F10E9.6a.1 |
| | | F10E9.6a.2 |
| | | F10E9.6a.3 |
| | | F10E9.6b.1 |
| | | F10E9.6c.1 |
| | Other_sequence (28) |
| | Associated_feature (66) |
| Experimental_info | RNAi_result (22) |
| | Expr_pattern (27) |
| | Drives_construct | WBCnstr00001004 |
| | | WBCnstr00003428 |
| | | WBCnstr00004230 |
| | | WBCnstr00011701 |
| | | WBCnstr00013113 |
| | | WBCnstr00016488 |
| | | WBCnstr00017477 |
| | | WBCnstr00017478 |
| | | WBCnstr00017479 |
| | Construct_product (12) |
| | Microarray_results (45) |
| | Expression_cluster | WBPaper00029359_1217 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1548 |
| | | WBPaper00029359_1604 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY15 |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056034:pals-25(jy9)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056855:his-72(uge40)_upregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00058725:sftb-1(cer39)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059224:tph-1(mg280)_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AVH_parent |
| | | WBPaper00061340:GLR |
| | | WBPaper00061340:Neuroblast_ASH_RIB |
| | | WBPaper00061340:Neuroblast_AVG_RIR |
| | | WBPaper00061340:Neuroblast_I6_M5 |
| | | WBPaper00061340:Parent_of_MI_pm1DR |
| | | WBPaper00061340:RME |
| | | WBPaper00061340:SIA |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061527:tub-2_4713-daf-2_5288 |
| | | WBPaper00061651:AVM_enriched |
| | | WBPaper00061651:FLP_enriched |
| | | WBPaper00061651:I4_enriched |
| | | WBPaper00061651:M3_enriched |
| | | WBPaper00061651:MC_enriched |
| | | WBPaper00061651:PVD_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065841:124_0 |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_6_4 |
| | | cgc4489_group_9 |
| | | cgc4489_group_17 |
| | | WBPaper00025032:cluster_74 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026952:class_A |
| | | WBPaper00027111:rde-3(ne298)_upregulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035873:osm-8_regulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040876:mir-35_upregulated |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00044091:Bpseudomallei_induced_8h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_5 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(143_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(143_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_B |
| | Interaction (65) |
| | Anatomy_function | WBbtf0493 |
| | | WBbtf0494 |
| | | WBbtf0815 |
| Map_info | Map | III | Position | -0.346394 | Error | 0.001792 |
| | Well_ordered |
| | Positive | Positive_clone | F10E9 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point (11) |
| | | Pos_neg_data | 4231 |
| | | | 4232 |
| | | | 4975 |
| Reference (58) |
| Method | Gene |
