| WBGene00003166 | SMap | S_parent | Sequence | CHROMOSOME_X |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | mec-2 | Person_evidence | WBPerson95 |
| | | Sequence_name | F14D12.4 |
| | | Molecular_name (51) |
| | | Other_name | CELE_F14D12.4 | Accession_evidence | NDB | BX284606 |
| | | Public_name | mec-2 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mec |
| | Allele (374) |
| | Legacy_information | See also e75, e1084, e1514 |
| | | [C.elegansII] u8amb : touch insensitive; lethargic. ES2. ME?. OA>50: e75 (recessive, ME3), u7cs, e1084 (probable null), e1514, e1608dm, u284sd, etc. Alleles vary in phenotype from weak recessive to strong dominant Mec; complex complementation. Cloned: encodes predicted 440 aa protein with central similarity to human stomatin (65% identity over 247 aa). mec-2:lacZ expressed in cell bodies and processes of touch cells, some other neurons.??? [Chalfie and Au 1989; Huang et al. 1995; TU] |
| | Strain | WBStrain00002820 |
| | | WBStrain00037747 |
| | | WBStrain00004463 |
| | | WBStrain00004092 |
| | RNASeq_FPKM (74) |
| | GO_annotation (26) |
| | Ortholog (36) |
| | Paralog | WBGene00006761 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006068 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006065 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006741 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006064 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006063 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006067 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006066 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006061 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | The mec-2 gene encodes a stomatin homolog required to sense gentle mechanical stimuli (e.g. touch) along the body wall. | Paper_evidence | WBPaper00005127 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables cholesterol binding activity. Involved in positive regulation of multicellular organismal process and response to mechanical stimulus. Located in neuron projection membrane. Expressed in sensory neurons. Used to study nephrotic syndrome. Is an ortholog of human STOM (stomatin). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:1184 | Homo sapiens | Paper_evidence | WBPaper00044961 |
| | | | | Accession_evidence | OMIM | 600995 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 25 Sep 2018 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000328 |
| Molecular_info | Corresponding_CDS (17) |
| | Corresponding_transcript (17) |
| | Other_sequence (86) |
| | Associated_feature (17) |
| Experimental_info | RNAi_result | WBRNAi00027647 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00013263 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00044585 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (18) |
| | Drives_construct | WBCnstr00003347 |
| | | WBCnstr00004794 |
| | | WBCnstr00010333 |
| | | WBCnstr00011303 |
| | | WBCnstr00011304 |
| | | WBCnstr00036204 |
| | | WBCnstr00042668 |
| | | WBCnstr00042669 |
| | Construct_product | WBCnstr00010333 |
| | | WBCnstr00011303 |
| | | WBCnstr00036204 |
| | Antibody | WBAntibody00000792 |
| | | WBAntibody00000793 |
| | | WBAntibody00001354 |
| | | WBAntibody00001686 |
| | | WBAntibody00002696 |
| | Microarray_results (40) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:BAG-neuron_embryo_enriched |
| | | WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040285:H2S_24hr_downregulated |
| | | WBPaper00040420:ALM_PLM_enriched |
| | | WBPaper00040420:FLP_enriched |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045316:prg-1_upregulated_L4 |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061274:microgravity_downregulated |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:ASG |
| | | WBPaper00061340:hmc |
| | | WBPaper00061340:hmc_homolog |
| | | WBPaper00061340:PLM |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:URX |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:C38C3.6-npr-7 |
| | | WBPaper00061527:mtd-1-mec-18 |
| | | WBPaper00061651:ALM_enriched |
| | | WBPaper00061651:AVM_enriched |
| | | WBPaper00061651:PLM_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00061651:RIR_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062520:qui-1(db104)_downregulated |
| | | WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:20_0 |
| | | WBPaper00065841:20_1 |
| | | WBPaper00065841:20_2 |
| | | WBPaper00065841:44_1 |
| | | WBPaper00065841:54_0 |
| | | WBPaper00065841:67_0 |
| | | WBPaper00065841:110_0 |
| | | WBPaper00065841:125_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_18 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Erwinia_carotovora_upregulated |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032948:StarveUp1 |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041939:control_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00042067:Cu2+_upregulated_WT |
| | | WBPaper00042128:gei-8(ok1671)_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (81) |
| | WBProcess | WBbiopr:00000002 |
| Map_info | Map | X | Position | -4.70552 | Error | 0.075755 |
| | Well_ordered |
| | Positive | Positive_clone | F14D12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | W05G12 | Remark | Alternative clone not in the golden path of clones. |
| | Negative | Outside_rearr | mcDf2 |
| | Mapping_data | Multi_point (11) |
| | | Pos_neg_data | 940 |
| | | | 1832 |
| | | | 3193 |
| | | | 500 |
| | | | 10696 |
| Reference (113) |
| Remark | Updated positive clone to correspond to the sequenced clone instead of just W05G12 |
| Method | Gene |
