WormBase Tree Display for Gene: WBGene00003007
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| WBGene00003007 | SMap | S_parent | Sequence | C16B8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lin-18 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C16B8.1 | ||||||||
| Molecular_name | C16B8.1 | ||||||||
| C16B8.1.1 | |||||||||
| CE44782 | |||||||||
| Other_name | CELE_C16B8.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | lin-18 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Reference_allele | WBVar00143343 | ||||||||
| Allele (54) | |||||||||
| Legacy_information | e620 : some (<50%) hermaphrodites have single small protrusion posterior to vulva occasional vulval rupture; slight maternal effect slightly ts. ES2. Males phenotypically wildtype ME3. NA2 (n1051amber ts (resembles e620)). | ||||||||
| See also e620, n1051 | |||||||||
| [C.elegansII] e620 : some (<50%) hermaphrodites have single small protrusion posterior to vulva, occasional vulval rupture; Polarity of 2ary lineages variably disrupted. slight maternal effect; slightly ts. e620/Df stronger phenotype. ES2. Males phenotypically wildtype ME3. OA1: n1051amb,ts (resembles e620). [Ferguson et al. 198; MT; PS] | |||||||||
| Strain | WBStrain00026854 | ||||||||
| WBStrain00026896 | |||||||||
| WBStrain00026934 | |||||||||
| WBStrain00027230 | |||||||||
| WBStrain00030926 | |||||||||
| WBStrain00004187 | |||||||||
| WBStrain00008502 | |||||||||
| WBStrain00008506 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (33) | |||||||||
| Structured_description | Concise_description | lin-18 encodes a predicted receptor tyrosine kinase that is a member of the Ryk/Derailed family of tyrosine kinase-related receptors (OMIM:600524, mutations in humans are associated with cleft palate); in C. elegans, LIN-18 is required for establishing the polarity of the secondary vulval cell lineage produced by the P7.p vulval precursor cell; LIN-18 may be a receptor for Wnt-like signaling molecules, and in vulval development appears to function independently of, but in parallel with, LIN-17, a Frizzled-like Wnt receptor, also required for proper orientation of the P7.p lineage; a lin-18 reporter gene is expressed in body wall muscle, neurons, and the developing vulva; in the vulva, expression is detected in P5.p, P6.p, and P7.p and all of their descendants during the L3 and L4 larval stages. | Paper_evidence | WBPaper00000762 | |||||
| WBPaper00000957 | |||||||||
| WBPaper00024383 | |||||||||
| WBPaper00024693 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 04 Aug 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; axis specification; and positive regulation of axon guidance. Located in cytoplasm; nucleus; and plasma membrane. Expressed in body wall musculature; neurons; vulva; and vulval precursor cell. Is an ortholog of human RYK (receptor like tyrosine kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C16B8.1 | |||||||
| Corresponding_CDS_history | C16B8.1:wp213 | ||||||||
| Corresponding_transcript | C16B8.1.1 | ||||||||
| Other_sequence | TMC03023_1 | ||||||||
| TM03073 | |||||||||
| JI170406.1 | |||||||||
| TM03074 | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00010820 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00040667 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098914 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101403 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101397 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027876 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101404 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101348 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101481 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3049 | ||||||||
| Expr15708 | |||||||||
| Expr1023205 | |||||||||
| Expr1031402 | |||||||||
| Expr1144715 | |||||||||
| Expr2013164 | |||||||||
| Expr2031396 | |||||||||
| Drives_construct | WBCnstr00004673 | ||||||||
| WBCnstr00011098 | |||||||||
| WBCnstr00019803 | |||||||||
| WBCnstr00036290 | |||||||||
| Construct_product | WBCnstr00004673 | ||||||||
| WBCnstr00019803 | |||||||||
| WBCnstr00019804 | |||||||||
| WBCnstr00036290 | |||||||||
| Antibody | WBAntibody00002553 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (122) | |||||||||
| Interaction (82) | |||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| Map_info | Map | X | Position | -8.8594 | Error | 0.06132 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C07F2 | |||||||
| C16B8 | Person_evidence | WBPerson625 | |||||||
| WBPerson1146 | |||||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| T19D2 | |||||||||
| Mapping_data | Multi_point (16) | ||||||||
| Pos_neg_data | 5833 | ||||||||
| 5008 | |||||||||
| 5009 | |||||||||
| 5011 | |||||||||
| 5012 | |||||||||
| Landmark_gene | |||||||||
| Reference (67) | |||||||||
| Method | Gene |
