WormBase Tree Display for Gene: WBGene00003007
expand all nodes | collapse all nodes | view schema
WBGene00003007 | SMap | S_parent | Sequence | C16B8 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lin | ||||||
Reference_allele | WBVar00143343 | ||||||
Allele (54) | |||||||
Legacy_information | e620 : some (<50%) hermaphrodites have single small protrusion posterior to vulva occasional vulval rupture; slight maternal effect slightly ts. ES2. Males phenotypically wildtype ME3. NA2 (n1051amber ts (resembles e620)). | ||||||
See also e620, n1051 | |||||||
[C.elegansII] e620 : some (<50%) hermaphrodites have single small protrusion posterior to vulva, occasional vulval rupture; Polarity of 2ary lineages variably disrupted. slight maternal effect; slightly ts. e620/Df stronger phenotype. ES2. Males phenotypically wildtype ME3. OA1: n1051amb,ts (resembles e620). [Ferguson et al. 198; MT; PS] | |||||||
Strain | WBStrain00026854 | ||||||
WBStrain00026896 | |||||||
WBStrain00026934 | |||||||
WBStrain00027230 | |||||||
WBStrain00030926 | |||||||
WBStrain00004187 | |||||||
WBStrain00008502 | |||||||
WBStrain00008506 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (36) | |||||||
Ortholog (37) | |||||||
Paralog (33) | |||||||
Structured_description | Concise_description | lin-18 encodes a predicted receptor tyrosine kinase that is a member of the Ryk/Derailed family of tyrosine kinase-related receptors (OMIM:600524, mutations in humans are associated with cleft palate); in C. elegans, LIN-18 is required for establishing the polarity of the secondary vulval cell lineage produced by the P7.p vulval precursor cell; LIN-18 may be a receptor for Wnt-like signaling molecules, and in vulval development appears to function independently of, but in parallel with, LIN-17, a Frizzled-like Wnt receptor, also required for proper orientation of the P7.p lineage; a lin-18 reporter gene is expressed in body wall muscle, neurons, and the developing vulva; in the vulva, expression is detected in P5.p, P6.p, and P7.p and all of their descendants during the L3 and L4 larval stages. | Paper_evidence | WBPaper00000762 | |||
WBPaper00000957 | |||||||
WBPaper00024383 | |||||||
WBPaper00024693 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 04 Aug 2005 00:00:00 | ||||||
Automated_description | Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; axis specification; and positive regulation of axon guidance. Located in cytoplasm; nucleus; and plasma membrane. Expressed in body wall musculature; neurons; vulva; and vulval precursor cell. Is an ortholog of human RYK (receptor like tyrosine kinase). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C16B8.1 | |||||
Corresponding_CDS_history | C16B8.1:wp213 | ||||||
Corresponding_transcript | C16B8.1.1 | ||||||
Other_sequence | TMC03023_1 | ||||||
TM03073 | |||||||
JI170406.1 | |||||||
TM03074 | |||||||
Associated_feature (14) | |||||||
Experimental_info | RNAi_result | WBRNAi00010820 | Inferred_automatically | RNAi_primary | |||
WBRNAi00040667 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098914 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101403 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101397 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027876 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101404 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101348 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101481 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr3049 | ||||||
Expr15708 | |||||||
Expr1023205 | |||||||
Expr1031402 | |||||||
Expr1144715 | |||||||
Expr2013164 | |||||||
Expr2031396 | |||||||
Drives_construct | WBCnstr00004673 | ||||||
WBCnstr00011098 | |||||||
WBCnstr00019803 | |||||||
WBCnstr00036290 | |||||||
Construct_product | WBCnstr00004673 | ||||||
WBCnstr00019803 | |||||||
WBCnstr00019804 | |||||||
WBCnstr00036290 | |||||||
Antibody | WBAntibody00002553 | ||||||
Microarray_results (22) | |||||||
Expression_cluster (122) | |||||||
Interaction (82) | |||||||
WBProcess | WBbiopr:00000073 | ||||||
Map_info | Map | X | Position | -8.8594 | Error | 0.06132 | |
Well_ordered | |||||||
Positive | Positive_clone | C07F2 | |||||
C16B8 | Person_evidence | WBPerson625 | |||||
WBPerson1146 | |||||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
T19D2 | |||||||
Mapping_data | Multi_point (16) | ||||||
Pos_neg_data | 5833 | ||||||
5008 | |||||||
5009 | |||||||
5011 | |||||||
5012 | |||||||
Landmark_gene | |||||||
Reference (67) | |||||||
Method | Gene |