| WBGene00002998 | SMap | S_parent | Sequence | ZK637 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | lin-9 | Person_evidence | WBPerson261 |
| | | Sequence_name | ZK637.7 |
| | | Molecular_name | ZK637.7a |
| | | | ZK637.7a.1 |
| | | | CE28194 |
| | | | ZK637.7b |
| | | | CE28195 |
| | | | ZK637.7b.1 |
| | | Other_name | CELE_ZK637.7 | Accession_evidence | NDB | BX284603 |
| | | Public_name | lin-9 |
| | DB_info | Database | AceView | gene | 3J990 |
| | | | WormQTL | gene | WBGene00002998 |
| | | | WormFlux | gene | WBGene00002998 |
| | | | NDB | locus_tag | CELE_ZK637.7 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00002998|UniProtKB=P30630 |
| | | | | family | PTHR21689 |
| | | | NCBI | gene | 176256 |
| | | | RefSeq | protein | NM_001027844.5 |
| | | | | | NM_001027845.6 |
| | | | SwissProt | UniProtAcc | P30630 |
| | | | TREEFAM | TREEFAM_ID | TF314315 |
| | | | UniProt_GCRP | UniProtAcc | P30630 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lin |
| | Allele (58) |
| | Legacy_information | n112 : adult hermaphrodite wildtype Muv in homozygotes with lin-8 or lin-38. NA3 (n942 n943 (sterile non-Muv alone sterile Muv with lin-8 etc.). |
| | | See also n112, n942, n943 |
| | | [C.elegansII] n112 : adult hermaphrodite wildtype Muv in homozygotes with lin-8 or lin-38. OA2: n942, n943 (both sterile non-Muv alone; sterile Muv with lin-8 etc.). Cloned: encodes predicted 642 aa novel protein, hydrophobic, possible C-term transmembrane domains. [Ferguson and Horvitz 1989; MT] |
| | Strain (12) |
| | RNASeq_FPKM (74) |
| | GO_annotation (21) |
| | Contained_in_operon | CEOP3878 |
| | Ortholog (36) |
| | Structured_description | Concise_description | lin-9 encodes two novel proteins that are conserved amongst C. elegans, Drosophila, plants, and vertebrates; lin-9 activity is required redundantly with activity of the synMuv A genes, such as lin-8, for negative regulation of the RTK/Ras-mediated signal transduction pathway that controls vulval development; in addition, lin-9 activity is required non-redundantly for hermaphrodite gonadal sheath cell development (and thus, reproduction), as well as for development of the male reproductive system including the male sensory rays and spicules. | Paper_evidence | WBPaper00000496 |
| | | | | | WBPaper00004314 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 02 Feb 2006 00:00:00 |
| | | Automated_description | Predicted to enable DNA binding activity. Involved in embryo development; male sex differentiation; and regulation of multicellular organismal development. Part of DRM complex. Is an ortholog of human LIN9 (lin-9 DREAM MuvB core complex component). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | ZK637.7a |
| | | ZK637.7b |
| | Corresponding_CDS_history | ZK637.7:wp52 |
| | Corresponding_transcript | ZK637.7a.1 |
| | | ZK637.7b.1 |
| | Other_sequence (23) |
| | Associated_feature (13) |
| Experimental_info | RNAi_result (19) |
| | Expr_pattern | Expr1024919 |
| | | Expr1031395 |
| | | Expr1163007 |
| | | Expr2013202 |
| | | Expr2031434 |
| | Drives_construct | WBCnstr00000434 |
| | | WBCnstr00036297 |
| | Construct_product | WBCnstr00000434 |
| | | WBCnstr00036297 |
| | Antibody | WBAntibody00001175 |
| | Microarray_results (28) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032031:DConiospora_upregulated_cDNA_24h |
| | | WBPaper00032425:up_in_lin-35 |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00035211:age-1_vs_age-1_upregulated |
| | | WBPaper00035211:age-1_vs_N2_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00038168:lin-35_upregulated |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040412:germline-regulated_daf-16_target |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00049954:BPS_downregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050686:glp-1(e2141)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:nucleus_specific |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059490:dcr-1(m9375)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061340:Neuroblast_ASE_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_M2_M3 |
| | | WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3 |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061527:cids-2_2203-attf-2_2451 |
| | | WBPaper00061527:let-99_22239-such-1 |
| | | WBPaper00062056:dpl-1(n2994)_upregulated |
| | | WBPaper00062056:lin-15B(n744)_upregulated |
| | | WBPaper00062056:lin-15B(we23)_upregulated |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062056:lin-36(we36)_upregulated |
| | | WBPaper00062056:lin-37(n758)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064107:lin-35(n745)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_2 |
| | | WBPaper00005124:testosterone_10-9M_regulated |
| | | WBPaper00025032:cluster_7 |
| | | WBPaper00025032:cluster_45 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_3d |
| | | WBPaper00041939:control_vs_EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-exposed_24h |
| | | WBPaper00042274:tbx-2(bx59)_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045960:L1-L4-lethargus_downregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_F |
| | | [cgc6390]:intrinsic |
| | Interaction (93) |
| Map_info | Map | III | Position | -0.006983 | Error | 0.001785 |
| | Well_ordered |
| | Positive | Positive_clone | ZK637 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 406 |
| | | | 407 |
| | | Multi_point | 325 |
| | | | 384 |
| | | | 385 |
| | | | 386 |
| | | | 387 |
| | | | 758 |
| | | | 759 |
| | | | 4957 |
| | | | 5435 |
| Reference (79) |
| Method | Gene |
