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WormBase Tree Display for Gene: WBGene00002991

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Name Class

WBGene00002991SMapS_parentSequenceF17E5
IdentityVersion1
NameCGC_namelin-2Person_evidenceWBPerson261
Sequence_nameF17E5.1
Molecular_nameF17E5.1a
F17E5.1a.1
CE27131
F17E5.1b
CE27132
F17E5.1b.1
Other_nameCELE_F17E5.1Accession_evidenceNDBBX284606
Public_namelin-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlin
Reference_alleleWBVar00143908
Allele (248)
Possibly_affected_byWBVar02157232
Legacy_informatione1309 : adult hermaphrodite vulvaless (penetrance 93%); ES2 (adult)/ ES1 (larvae); HME2; adult male wildtype ME3. NA13 (e1453amber (non-null lower penetrance than e1309 50% vulvaless) n105ts (penetrance 24% at 15x 90% at 25x) n768 (weak allele multiple vulval protrusions penetrance 21%) etc.).
See also e1309, e1424, e1437, e1453, n105, n167, n305, n380, n670, n674, n768, n1052, n1297, n1298
[C.elegansII] e1309 : adult hermaphrodite vulvaless (penetrance 93%); ES2 (adult)/ ES1 (larvae); HME2; adult male wildtype ME3. NA13: e1453amb (non-null, lower penetrance than e1309, 50% vulvaless), n105ts (penetrance 24% at 15C, 90% at 25C) n768 (weak allele multiple vulval protrusions penetrance 21%), n397 (deletes most of gene), etc. Cloned: encodes predicted protein with PDZ domain,similarity to guanylate kinase, Drosophila discs large. Mutants delocalize LET-23. [Ferguson et al. 1985; SD; MT]
Strain (14)
RNASeq_FPKM (74)
GO_annotation (26)
OrthologWBGene00051126Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00023607Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00153410Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00133225Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WBGene00163972Caenorhabditis brenneriFrom_analysisTreeFam
WBGene00136253Caenorhabditis japonicaFrom_analysisTreeFam
WBGene00062326Caenorhabditis remaneiFrom_analysisTreeFam
WBGene00232673Brugia malayiFrom_analysisWormBase-Compara
WBGene00268338Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g2786Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g8546Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g16693Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g17774Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g4407Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g5618Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g11436Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g14760Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g15630Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g10454Caenorhabditis tribulationisFrom_analysisWormBase-Compara
CSP40.g10455Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00833.g14472Caenorhabditis angariaFrom_analysisWormBase-Compara
Cang_2012_03_13_00833.g14473Caenorhabditis angariaFrom_analysisWormBase-Compara
Cnig_chr_X.g25079Caenorhabditis nigoniFrom_analysisWormBase-Compara
Cnig_chr_X.g25080Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g18775Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00076.g3480Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_03407Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_024992Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g11493Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g3894Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_X0225100Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrX_pilon.g20261Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00121102Caenorhabditis japonicaFrom_analysisWormBase-Compara
WBGene00239626Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00089578Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00257510Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00287097Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0013759Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-020802-4Danio rerioFrom_analysisInparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-030131-4473Danio rerioFrom_analysisInparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
HGNC:1497Homo sapiensFrom_analysisInparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:1309489Mus musculusFrom_analysisInparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:62004Rattus norvegicusFrom_analysisInparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ParalogWBGene00006467Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00016841Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00021914Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
Structured_descriptionConcise_descriptionlin-2 encodes a protein belonging to the membrane associated guanylate kinase (MAGUK) family, with several domains (L27, PDZ, SH3, and guanylate kinase) thought to assemble specific multiprotein complexes in particular regions of the cell; in vivo, LIN-2 is required for the correct localization of LET-23 (and, presumably, other membrane proteins) to specific regions of the plasma membrane.Paper_evidenceWBPaper00000496
WBPaper00003215
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated31 Jan 2006 00:00:00
Automated_descriptionEnables insulin-like growth factor receptor binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and protein localization to membrane. Located in cell junction. Expressed in several structures, including CAN; HSN; isthmus; somatic nervous system; and vulval precursor cell. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Is an ortholog of human CASK (calcium/calmodulin dependent serine protein kinase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_info (2)
Models_disease_assertedWBDOannot00000474
Molecular_infoCorresponding_CDSF17E5.1a
F17E5.1b
Corresponding_CDS_historyF17E5.1a:wp47
F17E5.1b:wp47
Corresponding_transcriptF17E5.1a.1
F17E5.1b.1
Other_sequence (49)
Associated_feature (16)
Experimental_infoRNAi_resultWBRNAi00013468Inferred_automaticallyRNAi_primary
WBRNAi00030265Inferred_automaticallyRNAi_primary
WBRNAi00044888Inferred_automaticallyRNAi_primary
WBRNAi00000540Inferred_automaticallyRNAi_primary
WBRNAi00076312Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00022290
WBCnstr00036300
Construct_productWBCnstr00012382
WBCnstr00021427
WBCnstr00036300
WBCnstr00038376
WBCnstr00038378
WBCnstr00041675
AntibodyWBAntibody00000973
WBAntibody00001507
Microarray_results (28)
Expression_cluster (169)
Interaction (292)
Map_infoMapXPosition7.04058Error0.007077
Well_ordered
PositiveInside_rearryDp11
Positive_cloneC43C10Inferred_automaticallyFrom sequence, transcript, pseudogene data
F17E5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point168
280
281
Multi_point (25)
Pos_neg_data320
686
687
871
8424
8431
8443
8451
8457
Landmark_gene
Reference (172)
MethodGene