WormBase Tree Display for Gene: WBGene00002981

WBGene00002981 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: ZK593
  Identity: Version: 2
    Name: CGC_name: lgg-2 Person_evidence: WBPerson321
      Sequence_name: ZK593.6
      Molecular_name: ZK593.6a
        ZK593.6a.1
        CE50405
        ZK593.6b
        CE45416
        ZK593.6b.1
      Other_name: atg-8.2 Person_evidence: WBPerson649
        CELE_ZK593.6 Accession_evidence: NDB BX284604
      Public_name: lgg-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 29 Feb 2008 11:29:00 WBPerson2970 Name_change: Other_name: atg-8.2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lgg
    Allele (37)
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog: WBGene00062492 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00028316 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00159574 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00153484 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00128015 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00227761 Brugia malayi From_analysis: WormBase-Compara
      WBGene00268385 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10931 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g14560 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g16135 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g12850 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g6902 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g15879 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g16138 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g18950 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g500 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g1420 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-lgg-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g7992 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00007.g503 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_12859 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_014019 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02899 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g13555 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g24137 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_40308900 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g11720 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00241026 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00275740 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00266551 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00288869 Trichuris muris From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-030131-1145 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2232 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:13352 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6838 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:34390 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1915661 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1914693 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:621315 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:735183 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00002980 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: lgg-2 encodes an ortholog of the autophagic budding yeast protein Atg8p;LGG-2 is also homologous the light chain 3 (LC3) subunit of themicrotubule-associated proteins 1A and 1B (MAP1A and MAP1B); LGG-2 is predicted to associate with MAP1A and MAP1B and with microtubules and toperhaps play a role in regulating the microtubule-binding activity ofMAP1A and MAP1B; LGG-2 has no obvious function in RNAi assays, and isnot required for either dauer formation or extended lifespan. Paper_evidence: WBPaper00005654
            WBPaper00006070
            WBPaper00031504
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 16 Mar 2008 00:00:00
      Automated_description: Predicted to enable microtubule binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to toxic substance; defense response to other organism; and positive regulation of autophagosome maturation. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Expressed in hypodermis; muscle cell; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in glioblastoma; hypertrophic cardiomyopathy; and liver cirrhosis. Is an ortholog of human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha); MAP1LC3B (microtubule associated protein 1 light chain 3 beta); and MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3068 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6838)
      DOID:11984 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6838)
      DOID:5082 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6838)
  Molecular_info: Corresponding_CDS: ZK593.6a
      ZK593.6b
    Corresponding_CDS_history: ZK593.6a:wp246
    Corresponding_transcript: ZK593.6a.1
      ZK593.6b.1
    Other_sequence (78)
    Associated_feature (15)
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr9088
      Expr11489
      Expr12743
      Expr1019064
      Expr1031381
      Expr1162945
      Expr2013143
      Expr2031375
    Drives_construct: WBCnstr00009398
      WBCnstr00013713
      WBCnstr00019050
      WBCnstr00022725
      WBCnstr00036308
    Construct_product: WBCnstr00009398
      WBCnstr00013713
      WBCnstr00019050
      WBCnstr00022269
      WBCnstr00036308
    Antibody: WBAntibody00002496
      WBAntibody00002979
    Microarray_results (29)
    Expression_cluster (162)
    Interaction (120)
  Map_info: Map: IV Position: 4.75551 Error: 0.001217
    Positive: Positive_clone: ZK593 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (48)
  Remark: Sequence connection from [Kimura Y]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene