lgg-2 encodes an ortholog of the autophagic budding yeast protein Atg8p;LGG-2 is also homologous the light chain 3 (LC3) subunit of themicrotubule-associated proteins 1A and 1B (MAP1A and MAP1B); LGG-2 is predicted to associate with MAP1A and MAP1B and with microtubules and toperhaps play a role in regulating the microtubule-binding activity ofMAP1A and MAP1B; LGG-2 has no obvious function in RNAi assays, and isnot required for either dauer formation or extended lifespan.
Predicted to enable microtubule binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to toxic substance; defense response to other organism; and positive regulation of autophagosome maturation. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Expressed in hypodermis; muscle cell; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in glioblastoma; hypertrophic cardiomyopathy; and liver cirrhosis. Is an ortholog of human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha); MAP1LC3B (microtubule associated protein 1 light chain 3 beta); and MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.