WormBase Tree Display for Gene: WBGene00002980
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WBGene00002980 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C32D5 | ||||
Identity | Version | 2 | |||||
Name | CGC_name | lgg-1 | Person_evidence | WBPerson321 | |||
Sequence_name | C32D5.9 | ||||||
Molecular_name | C32D5.9 | ||||||
C32D5.9.1 | |||||||
CE01849 | |||||||
Other_name | 2G636 | Accession_evidence | EMBL | AF326943 | |||
atg-8.1 | Person_evidence | WBPerson649 | |||||
CELE_C32D5.9 | Accession_evidence | NDB | BX284602 | ||||
Public_name | lgg-1 | ||||||
DB_info | Database (10) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lgg | ||||||
Allele (16) | |||||||
Strain | WBStrain00002645 | ||||||
WBStrain00003898 | |||||||
WBStrain00003955 | |||||||
WBStrain00033311 | |||||||
Component_of_genotype | WBGenotype00000129 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (58) | |||||||
Contained_in_operon | CEOP2240 | ||||||
Ortholog (41) | |||||||
Paralog | WBGene00002981 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | lgg-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Atg8p and mammalian MAP-LC3; by homology, LGG-1 is predicted to be required for the degradation of cellular components by autophagy; loss of lgg-1 function via RNAi indicates that, like several other C. elegans genes involved in autophagy, lgg-1 is essential for normal dauer morphogenesis and life-span extension; a GFP::LGG-1 reporter fusion protein is expression in several different stages of development in multiple tissues, including the nervous system, pharynx, intestine, hypodermis, somatic gonad and vulva; under normal growth conditions, GFP::LGG-1 shows a diffuse cytoplasmic localization, but during dauer formation and in long-lived animals, GFP::LGG-1 shows a marked increase in punctate staining in hypodermal seam cells that likely reflects an increase in the number of preautophagosomal and autophagosomal structures. | Paper_evidence | WBPaper00006070 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 10 Apr 2007 00:00:00 | ||||||
Automated_description | Predicted to enable GABA receptor binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to other organism; plasma membrane repair; and positive regulation of autophagosome assembly. Located in bounding membrane of organelle; neuron projection; and neuronal cell body. Expressed in several structures, including egg-laying apparatus; germ cell; hypodermis; intestine; and nervous system. Is an ortholog of human GABARAP (GABA type A receptor-associated protein). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Modifies_disease | DOID:332 | ||||||
Modifies_disease_in_annotation | WBDOannot00001227 | ||||||
Molecular_info | Corresponding_CDS | C32D5.9 | |||||
Corresponding_transcript | C32D5.9.1 | ||||||
Other_sequence (181) | |||||||
Associated_feature (11) | |||||||
Experimental_info | RNAi_result (59) | ||||||
Expr_pattern (17) | |||||||
Drives_construct (18) | |||||||
Construct_product (37) | |||||||
Antibody | WBAntibody00002128 | ||||||
WBAntibody00002775 | |||||||
WBAntibody00002776 | |||||||
WBAntibody00002864 | |||||||
WBAntibody00002888 | |||||||
WBAntibody00002907 | |||||||
WBAntibody00003022 | |||||||
Microarray_results (18) | |||||||
Expression_cluster (165) | |||||||
Interaction (287) | |||||||
WBProcess | WBbiopr:00000003 | ||||||
Map_info | Map | II | Position | -0.380826 | Error | 0.000183 | |
Positive | Positive_clone | C32D5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (176) | |||||||
Remark | Sequence connection from [Kimura Y] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |