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WormBase Tree Display for Disease_model_annotation: WBDOannot00001227

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Name Class

WBDOannot00001227Disease_termDOID:332
Disease_of_speciesHomo sapiens
Modeled_byGenotypeWBGenotype00000129
Asserted_human_geneHGNC:11179
Association_typeis_ameliorated_model_of
Evidence_codeGO_codeIMP
ECO_termECO:0007013
Modifier_infoModifier_geneWBGene00002980
Modifier_association_typecondition_ameliorated_by
Genetic_sexhermaphrodite
Paper_evidenceWBPaper00062451
Disease_model_descriptionTransgenic expression of the ALS-associated human SOD1[G93A] mutant in C. elegans results in motor neuron degeneration and shortened lifespan of worms, recapitulating ALS-like phenotypes. Overexpression of lgg-1 alleviated the toxic effects of SOD1[G93A], suggesting that lgg-1 overexpression induces the degeneration of hSOD1 protein and alleviates the toxic effects of the hSOD1 mutation.
Curator_confirmedWBPerson324
Date_last_updated08 Jun 2022 00:00:00