WormBase Tree Display for Disease_model_annotation: WBDOannot00001227
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WBDOannot00001227 | Disease_term | DOID:332 | |
---|---|---|---|
Disease_of_species | Homo sapiens | ||
Modeled_by | Genotype | WBGenotype00000129 | |
Asserted_human_gene | HGNC:11179 | ||
Association_type | is_ameliorated_model_of | ||
Evidence_code | GO_code | IMP | |
ECO_term | ECO:0007013 | ||
Modifier_info | Modifier_gene | WBGene00002980 | |
Modifier_association_type | condition_ameliorated_by | ||
Genetic_sex | hermaphrodite | ||
Paper_evidence | WBPaper00062451 | ||
Disease_model_description | Transgenic expression of the ALS-associated human SOD1[G93A] mutant in C. elegans results in motor neuron degeneration and shortened lifespan of worms, recapitulating ALS-like phenotypes. Overexpression of lgg-1 alleviated the toxic effects of SOD1[G93A], suggesting that lgg-1 overexpression induces the degeneration of hSOD1 protein and alleviates the toxic effects of the hSOD1 mutation. | ||
Curator_confirmed | WBPerson324 | ||
Date_last_updated | 08 Jun 2022 00:00:00 |