WormBase Tree Display for Gene: WBGene00002981
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| WBGene00002981 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | ZK593 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | lgg-2 | Person_evidence | WBPerson321 | |||||
| Sequence_name | ZK593.6 | ||||||||
| Molecular_name | ZK593.6a | ||||||||
| ZK593.6a.1 | |||||||||
| CE50405 | |||||||||
| ZK593.6b | |||||||||
| CE45416 | |||||||||
| ZK593.6b.1 | |||||||||
| Other_name | atg-8.2 | Person_evidence | WBPerson649 | ||||||
| CELE_ZK593.6 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | lgg-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 29 Feb 2008 11:29:00 | WBPerson2970 | Name_change | Other_name | atg-8.2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lgg | ||||||||
| Allele (37) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00002980 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | lgg-2 encodes an ortholog of the autophagic budding yeast protein Atg8p;LGG-2 is also homologous the light chain 3 (LC3) subunit of themicrotubule-associated proteins 1A and 1B (MAP1A and MAP1B); LGG-2 is predicted to associate with MAP1A and MAP1B and with microtubules and toperhaps play a role in regulating the microtubule-binding activity ofMAP1A and MAP1B; LGG-2 has no obvious function in RNAi assays, and isnot required for either dauer formation or extended lifespan. | Paper_evidence | WBPaper00005654 | |||||
| WBPaper00006070 | |||||||||
| WBPaper00031504 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 16 Mar 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable microtubule binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to toxic substance; defense response to other organism; and positive regulation of autophagosome maturation. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Expressed in hypodermis; muscle cell; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in glioblastoma; hypertrophic cardiomyopathy; and liver cirrhosis. Is an ortholog of human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha); MAP1LC3B (microtubule associated protein 1 light chain 3 beta); and MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3068 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6838) | ||||
| DOID:11984 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6838) | ||||||
| DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6838) | ||||||
| Molecular_info | Corresponding_CDS | ZK593.6a | |||||||
| ZK593.6b | |||||||||
| Corresponding_CDS_history | ZK593.6a:wp246 | ||||||||
| Corresponding_transcript | ZK593.6a.1 | ||||||||
| ZK593.6b.1 | |||||||||
| Other_sequence (78) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result (21) | ||||||||
| Expr_pattern | Expr9088 | ||||||||
| Expr11489 | |||||||||
| Expr12743 | |||||||||
| Expr1019064 | |||||||||
| Expr1031381 | |||||||||
| Expr1162945 | |||||||||
| Expr2013143 | |||||||||
| Expr2031375 | |||||||||
| Drives_construct | WBCnstr00009398 | ||||||||
| WBCnstr00013713 | |||||||||
| WBCnstr00019050 | |||||||||
| WBCnstr00022725 | |||||||||
| WBCnstr00036308 | |||||||||
| Construct_product | WBCnstr00009398 | ||||||||
| WBCnstr00013713 | |||||||||
| WBCnstr00019050 | |||||||||
| WBCnstr00022269 | |||||||||
| WBCnstr00036308 | |||||||||
| Antibody | WBAntibody00002496 | ||||||||
| WBAntibody00002979 | |||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (162) | |||||||||
| Interaction (120) | |||||||||
| Map_info | Map | IV | Position | 4.75551 | Error | 0.001217 | |||
| Positive | Positive_clone | ZK593 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (48) | |||||||||
| Remark | Sequence connection from [Kimura Y] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
