WormBase Tree Display for Gene: WBGene00002980
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| WBGene00002980 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C32D5 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | lgg-1 | Person_evidence | WBPerson321 | |||||
| Sequence_name | C32D5.9 | ||||||||
| Molecular_name | C32D5.9 | ||||||||
| C32D5.9.1 | |||||||||
| CE01849 | |||||||||
| Other_name | 2G636 | Accession_evidence | EMBL | AF326943 | |||||
| atg-8.1 | Person_evidence | WBPerson649 | |||||||
| CELE_C32D5.9 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | lgg-1 | ||||||||
| DB_info | Database | AceView | gene | 2G636 | |||||
| WormQTL | gene | WBGene00002980 | |||||||
| WormFlux | gene | WBGene00002980 | |||||||
| NDB | locus_tag | CELE_C32D5.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002980|UniProtKB=Q09490 | |||||||
| family | PTHR10969 | ||||||||
| NCBI | gene | 174050 | |||||||
| RefSeq | protein | NM_062876.8 | |||||||
| SwissProt | UniProtAcc | Q09490 | |||||||
| TREEFAM | TREEFAM_ID | TF314556 | |||||||
| UniProt_GCRP | UniProtAcc | Q09490 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 29 Feb 2008 11:29:00 | WBPerson2970 | Name_change | Other_name | atg-8.1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lgg | ||||||||
| Allele (16) | |||||||||
| Strain | WBStrain00002645 | ||||||||
| WBStrain00003898 | |||||||||
| WBStrain00003955 | |||||||||
| WBStrain00033311 | |||||||||
| Component_of_genotype | WBGenotype00000129 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (58) | |||||||||
| Contained_in_operon | CEOP2240 | ||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00002981 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | lgg-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Atg8p and mammalian MAP-LC3; by homology, LGG-1 is predicted to be required for the degradation of cellular components by autophagy; loss of lgg-1 function via RNAi indicates that, like several other C. elegans genes involved in autophagy, lgg-1 is essential for normal dauer morphogenesis and life-span extension; a GFP::LGG-1 reporter fusion protein is expression in several different stages of development in multiple tissues, including the nervous system, pharynx, intestine, hypodermis, somatic gonad and vulva; under normal growth conditions, GFP::LGG-1 shows a diffuse cytoplasmic localization, but during dauer formation and in long-lived animals, GFP::LGG-1 shows a marked increase in punctate staining in hypodermal seam cells that likely reflects an increase in the number of preautophagosomal and autophagosomal structures. | Paper_evidence | WBPaper00006070 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Apr 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable GABA receptor binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to other organism; plasma membrane repair; and positive regulation of autophagosome assembly. Located in bounding membrane of organelle; neuron projection; and neuronal cell body. Expressed in several structures, including egg-laying apparatus; germ cell; hypodermis; intestine; and nervous system. Is an ortholog of human GABARAP (GABA type A receptor-associated protein). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Modifies_disease | DOID:332 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00001227 | ||||||||
| Molecular_info | Corresponding_CDS | C32D5.9 | |||||||
| Corresponding_transcript | C32D5.9.1 | ||||||||
| Other_sequence (181) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (59) | ||||||||
| Expr_pattern (17) | |||||||||
| Drives_construct (18) | |||||||||
| Construct_product (37) | |||||||||
| Antibody | WBAntibody00002128 | ||||||||
| WBAntibody00002775 | |||||||||
| WBAntibody00002776 | |||||||||
| WBAntibody00002864 | |||||||||
| WBAntibody00002888 | |||||||||
| WBAntibody00002907 | |||||||||
| WBAntibody00003022 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (165) | |||||||||
| Interaction (287) | |||||||||
| WBProcess | WBbiopr:00000003 | ||||||||
| Map_info | Map | II | Position | -0.380826 | Error | 0.000183 | |||
| Positive | Positive_clone | C32D5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (176) | |||||||||
| Remark | Sequence connection from [Kimura Y] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
