WBGene00002978 | SMap | S_parent | Sequence | Y105E8B |
| Identity | Version | 1 |
| | Name | CGC_name | lev-11 | Person_evidence | WBPerson368 |
| | | Sequence_name | Y105E8B.1 |
| | | Molecular_name (58) |
| | | Other_name | tmy-1 |
| | | | Y105E8B.c | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | CeTM | Paper_evidence | WBPaper00005168 |
| | | | | | WBPaper00032338 |
| | | | CELE_Y105E8B.1 | Accession_evidence | NDB | BX284601 |
| | | Public_name | lev-11 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lev |
| | Reference_allele | WBVar00275207 |
| | Allele (206) |
| | Legacy_information | x12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal). |
| | | See also e1724 |
| | | [Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping. |
| | | [C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS. |
| | | [C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK] |
| | Strain | WBStrain00002959 |
| | | WBStrain00033515 |
| | | WBStrain00033518 |
| | | WBStrain00033524 |
| | | WBStrain00040917 |
| | | WBStrain00040918 |
| | | WBStrain00004923 |
| | RNASeq_FPKM (74) |
| | GO_annotation (20) |
| | Ortholog | WBGene00060848 | Caenorhabditis remanei | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | WBGene00038957 | Caenorhabditis briggsae | From_analysis | Hillier-set |
| | | | | | OrthoMCL |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00157417 | Caenorhabditis brenneri | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | WBGene00080168 | Caenorhabditis remanei | From_analysis | OMA |
| | | WBGene00121673 | Caenorhabditis japonica | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00113939 | Pristionchus pacificus | From_analysis | Inparanoid_8 |
| | | WBGene00268837 | Brugia malayi | From_analysis | WormBase-Compara |
| | | CSP21.g6566 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara |
| | | CSP26.g5884 | Caenorhabditis zanzibari | From_analysis | WormBase-Compara |
| | | CSP28.g8286 | Caenorhabditis panamensis | From_analysis | WormBase-Compara |
| | | CSP29.g13409 | Caenorhabditis becei | From_analysis | WormBase-Compara |
| | | CSP31.g6003 | Caenorhabditis uteleia | From_analysis | WormBase-Compara |
| | | CSP39.g12379 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara |
| | | Cnig_chr_I.g3904 | Caenorhabditis nigoni | From_analysis | WormBase-Compara |
| | | Csp11.Scaffold630.g19026 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara |
| | | Csp5_scaffold_00354.g9973 | Caenorhabditis sinica | From_analysis | WormBase-Compara |
| | | FL83_09174 | Caenorhabditis latens | From_analysis | WormBase-Compara |
| | | GCK72_001496 | Caenorhabditis remanei | From_analysis | WormBase-Compara |
| | | OTIPU.nOt.2.0.1.g05518 | Oscheius tipulae | From_analysis | WormBase-Compara |
| | | Pan_g8532 | Panagrellus redivivus | From_analysis | WormBase-Compara |
| | | Sp34_10004400 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | chrI_pilon.g2931 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00238002 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00259763 | Strongyloides ratti | From_analysis | WormBase-Compara |
| | | WBGene00287695 | Trichuris muris | From_analysis | WormBase-Compara |
| | | SGD:S000005023 | Saccharomyces cerevisiae | From_analysis | OMA |
| | | | | | Panther |
| | | FB:FBgn0003721 | Drosophila melanogaster | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | FB:FBgn0004117 | Drosophila melanogaster | From_analysis | EnsEMBL-Compara |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | ZFIN:ZDB-GENE-990415-269 | Danio rerio | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-030131-2964 | Danio rerio | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-030826-16 | Danio rerio | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-040426-854 | Danio rerio | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-040426-2185 | Danio rerio | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-040625-114 | Danio rerio | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | HGNC:12010 | Homo sapiens | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | HGNC:12011 | Homo sapiens | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | HGNC:12012 | Homo sapiens | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | HGNC:12013 | Homo sapiens | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | MGI:98809 | Mus musculus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | MGI:98810 | Mus musculus | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | MGI:1890149 | Mus musculus | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | MGI:2449202 | Mus musculus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | MGI:99705 | Mus musculus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | RGD:3898 | Rattus norvegicus | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | RGD:3899 | Rattus norvegicus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | RGD:621546 | Rattus norvegicus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | RGD:1559479 | Rattus norvegicus | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | Structured_description | Concise_description | lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. | Paper_evidence | WBPaper00002748 |
| | | | | | WBPaper00004944 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0111597 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) |
| | | DOID:0110926 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) |
| | | DOID:0110309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) |
| | | DOID:0110457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) |
| | | DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) |
| | | DOID:0110932 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) |
| | | DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) |
| | | DOID:0080102 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) |
| | | DOID:2218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12013) |
| Molecular_info | Corresponding_CDS (19) |
| | Corresponding_CDS_history | Y105E8B.1b:wp62 |
| | | Y105E8B.1b:wp114 |
| | | Y105E8B.1c:wp62 |
| | Corresponding_transcript (20) |
| | Other_sequence (913) |
| | Associated_feature (35) |
| Experimental_info | RNAi_result | WBRNAi00065527 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077371 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00066821 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00064047 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061185 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077373 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061195 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077376 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080639 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00073321 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077374 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00085019 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00085020 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00028216 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00065529 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00085017 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061192 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00065528 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00065526 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077372 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00085016 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00055236 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061187 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00064048 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077375 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061188 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00073322 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061196 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00064046 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061189 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00073323 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (15) |
| | Drives_construct (12) |
| | Construct_product | WBCnstr00010369 |
| | | WBCnstr00012505 |
| | | WBCnstr00016244 |
| | | WBCnstr00041176 |
| | Antibody | WBAntibody00000099 |
| | | WBAntibody00000422 |
| | | WBAntibody00000423 |
| | | WBAntibody00000472 |
| | Microarray_results (61) |
| | Expression_cluster (304) |
| | Interaction (175) |
| | WBProcess | WBbiopr:00000006 |
| Map_info | Map | I | Position | 25.8125 | Error | 0.018971 |
| | Well_ordered |
| | Positive | Positive_clone | Y105E8B | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 209 |
| | | | 213 |
| | | | 214 |
| | | | 327 |
| | | | 5106 |
| | | | 6076 |
| | | Multi_point (11) |
| | | Pos_neg_data (13) |
| Reference (90) |
| Remark | Data extracted from Williams & Waterston 1994 |
| | The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02 |
| Method | Gene |