| WBGene00002275 | Evidence | Paper_evidence | WBPaper00004339 |
|---|
| SMap | S_parent | Sequence | CHROMOSOME_II |
| Identity | Version | 1 |
| | Name | CGC_name | lem-2 |
| | | Sequence_name | W01G7.5 |
| | | Molecular_name | W01G7.5 |
| | | | W01G7.5.1 |
| | | | CE20129 |
| | | Other_name | Y39G8C.a | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | CeMAN1 | Paper_evidence | WBPaper00024687 |
| | | | CELE_W01G7.5 | Accession_evidence | NDB | BX284602 |
| | | Public_name | lem-2 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lem |
| | Allele (91) |
| | Possibly_affected_by | WBVar02153030 |
| | Strain | WBStrain00036509 |
| | | WBStrain00003846 |
| | | WBStrain00047808 |
| | RNASeq_FPKM (74) |
| | GO_annotation (28) |
| | Contained_in_operon | CEOP2724 |
| | Ortholog (26) |
| | Structured_description | Concise_description | lem-2 encodes the ortholog of the vertebrate LEM2 and MAN1 proteins and contains a LEM domain which is a defining 40 amino acid motif shared by a family of nuclear envelope proteins; LEM family proteins bind to lamins and to the small inner nuclear membrane associated protein BAF; LEM-2 provides an anchor by which chromosomes are attached to the nuclear membrane; lem-2 together with the LEM domain protein emr-1/emerin, bind lmn-1/lamin and are required for viability and proper chromosome segregation; LEM-2 localizes to the nuclear membrane; lem-2 mutations also exhibit moderate hypersensitivity to DNA damage. | Paper_evidence | WBPaper00005828 |
| | | | | | WBPaper00037942 |
| | | | | | WBPaper00040826 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | Date_last_updated | 12 Apr 2012 00:00:00 |
| | | Automated_description | Enables chromatin DNA binding activity and lamin binding activity. Involved in several processes, including mitotic cytokinesis; organelle organization; and response to X-ray. Located in chromosome and nuclear envelope. Used to study Emery-Dreifuss muscular dystrophy and cataract 46 juvenile-onset. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Is an ortholog of human LEMD2 (LEM domain nuclear envelope protein 2) and LEMD3 (LEM domain containing 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00046424 |
| | | | | Accession_evidence | OMIM | 181350 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 04 Jan 2013 00:00:00 |
| | | DOID:0110243 | Homo sapiens | Paper_evidence | WBPaper00059881 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 27 Jun 2020 00:00:00 |
| | Potential_model | DOID:0111536 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:28887) |
| | | DOID:0110243 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21244) |
| | Disease_relevance | Mutations in the human ortholog of lem-2, LEMD3, which encodes the MAN1 nuclear membrane protein, are found in Buschke-Ollendorff syndrome, Melorheostosis and Osteopoikilosis; MAN1 belongs to the family of LEM domain proteins that bind lamin and include nuclear lamina proteins like Emerin, LEM2/NET25, and several others; much of the knowledge of the organization and assembly of the nuclear lamina has come from studies in elegans; studies in elegans have demonstrated the overlapping roles of emerin and LEM-2 in embryogenesis, cell proliferation, lamin and heterochromatin organization; worm emerin and lem-2 are also involved in mitosis, smooth and striated muscle function, lifespan and meiotic progression, pointing to the many underlying processes that may affect disease phenotypes. | Homo sapiens | Paper_evidence | WBPaper00040268 |
| | | | | Accession_evidence | OMIM | 166700 |
| | | | | | | 155950 |
| | | | | | | 16670 |
| | | | | | | 607844 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 06 Mar 2012 00:00:00 |
| Models_disease_asserted | WBDOannot00000047 |
| | WBDOannot00000768 |
| | WBDOannot00000769 |
| | WBDOannot00000770 |
| | WBDOannot00000771 |
| Molecular_info | Corresponding_CDS | W01G7.5 |
| | Corresponding_transcript | W01G7.5.1 |
| | Other_sequence (19) |
| | Associated_feature | WBsf644830 |
| | | WBsf658388 |
| | | WBsf976399 |
| | | WBsf976400 |
| | | WBsf981354 |
| | | WBsf990618 |
| | | WBsf1013767 |
| | | WBsf222419 |
| | | WBsf222420 |
| | | WBsf222421 |
| Experimental_info | RNAi_result (15) |
| | Expr_pattern | Expr9180 |
| | | Expr10879 |
| | | Expr11504 |
| | | Expr12212 |
| | | Expr1014258 |
| | | Expr1031341 |
| | | Expr1158080 |
| | | Expr2013044 |
| | | Expr2031276 |
| | Drives_construct | WBCnstr00018933 |
| | | WBCnstr00020602 |
| | Construct_product | WBCnstr00001838 |
| | | WBCnstr00017548 |
| | | WBCnstr00018933 |
| | | WBCnstr00020602 |
| | Regulate_expr_cluster | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00044786:lem-2(tm1582)_downregulated |
| | | WBPaper00044786:lem-2(tm1582)_upregulated |
| | Antibody | WBAntibody00000308 |
| | | WBAntibody00000309 |
| | | WBAntibody00000310 |
| | | WBAntibody00000311 |
| | | WBAntibody00001855 |
| | | WBAntibody00002216 |
| | | WBAntibody00002346 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032031:DConiospora_downregulated_cDNA_12h |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00033070:Elbe_downregulated |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00035211:age-1_vs_age-1_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00042477:prp-8(RNAi)_upregulated_RNAseq |
| | | WBPaper00042561:smg-2(RNAi)_downregulated |
| | | WBPaper00044037:eat-2_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_upregulated_Day10 |
| | | WBPaper00044746:aging_upregulated_HeatShock |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045420:fertilization_upregulated_protein |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049290:rsks-1(sv31)_downregulated |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050686:glp-1(e2141)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050743:elli-1(sam-3)_downregulated |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:nucleus_specific |
| | | WBPaper00051265:F1_morc-1(tm6048)_downregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00052987:UV_upregulated_xpc-1;csb-1 |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056284:ints-1(RNAi)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058711:paraquat_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:ADA_ADE_grandparent |
| | | WBPaper00061340:g2 |
| | | WBPaper00061340:MC |
| | | WBPaper00061340:PVQ_parent |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061527:cyn-10_19153-K12H4.2 |
| | | WBPaper00062146:MOG-7-degron_2h_regulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00063976:micu-1(bon20)_upregulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064403:Heat-killed-E.Coli_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064789:Day9_vs_Day1_upregulated_neuron |
| | | WBPaper00064789:Day12_vs_Day1_upregulated_neuron |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065315:mating_upregulated_Day2-7 |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_transcript |
| | | WBPaper00065945:global-rpoa-2(-)_upregulated_transcript |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_2 |
| | | WBPaper00027111:eri-1(mg366)_upregulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045673:colistin_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(83_min) |
| | | [cgc6390]:Cluster_F |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (35) |
| Map_info (4) |
| Reference (43) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
