WormBase Tree Display for Gene: WBGene00002275
expand all nodes | collapse all nodes | view schema
| WBGene00002275 | Evidence | Paper_evidence | WBPaper00004339 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_II | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | lem-2 | |||||||
| Sequence_name | W01G7.5 | ||||||||
| Molecular_name | W01G7.5 | ||||||||
| W01G7.5.1 | |||||||||
| CE20129 | |||||||||
| Other_name | Y39G8C.a | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CeMAN1 | Paper_evidence | WBPaper00024687 | |||||||
| CELE_W01G7.5 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | lem-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lem | ||||||||
| Allele (91) | |||||||||
| Possibly_affected_by | WBVar02153030 | ||||||||
| Strain | WBStrain00036509 | ||||||||
| WBStrain00003846 | |||||||||
| WBStrain00047808 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Contained_in_operon | CEOP2724 | ||||||||
| Ortholog (26) | |||||||||
| Structured_description | Concise_description | lem-2 encodes the ortholog of the vertebrate LEM2 and MAN1 proteins and contains a LEM domain which is a defining 40 amino acid motif shared by a family of nuclear envelope proteins; LEM family proteins bind to lamins and to the small inner nuclear membrane associated protein BAF; LEM-2 provides an anchor by which chromosomes are attached to the nuclear membrane; lem-2 together with the LEM domain protein emr-1/emerin, bind lmn-1/lamin and are required for viability and proper chromosome segregation; LEM-2 localizes to the nuclear membrane; lem-2 mutations also exhibit moderate hypersensitivity to DNA damage. | Paper_evidence | WBPaper00005828 | |||||
| WBPaper00037942 | |||||||||
| WBPaper00040826 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 12 Apr 2012 00:00:00 | ||||||||
| Automated_description | Enables chromatin DNA binding activity and lamin binding activity. Involved in several processes, including mitotic cytokinesis; organelle organization; and response to X-ray. Located in chromosome and nuclear envelope. Used to study Emery-Dreifuss muscular dystrophy and cataract 46 juvenile-onset. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Is an ortholog of human LEMD2 (LEM domain nuclear envelope protein 2) and LEMD3 (LEM domain containing 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00046424 | ||||
| Accession_evidence | OMIM | 181350 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Jan 2013 00:00:00 | ||||||||
| DOID:0110243 | Homo sapiens | Paper_evidence | WBPaper00059881 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 27 Jun 2020 00:00:00 | ||||||||
| Potential_model | DOID:0111536 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:28887) | |||||
| DOID:0110243 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21244) | ||||||
| Disease_relevance | Mutations in the human ortholog of lem-2, LEMD3, which encodes the MAN1 nuclear membrane protein, are found in Buschke-Ollendorff syndrome, Melorheostosis and Osteopoikilosis; MAN1 belongs to the family of LEM domain proteins that bind lamin and include nuclear lamina proteins like Emerin, LEM2/NET25, and several others; much of the knowledge of the organization and assembly of the nuclear lamina has come from studies in elegans; studies in elegans have demonstrated the overlapping roles of emerin and LEM-2 in embryogenesis, cell proliferation, lamin and heterochromatin organization; worm emerin and lem-2 are also involved in mitosis, smooth and striated muscle function, lifespan and meiotic progression, pointing to the many underlying processes that may affect disease phenotypes. | Homo sapiens | Paper_evidence | WBPaper00040268 | |||||
| Accession_evidence | OMIM | 166700 | |||||||
| 155950 | |||||||||
| 16670 | |||||||||
| 607844 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Mar 2012 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000047 | ||||||||
| WBDOannot00000768 | |||||||||
| WBDOannot00000769 | |||||||||
| WBDOannot00000770 | |||||||||
| WBDOannot00000771 | |||||||||
| Molecular_info | Corresponding_CDS | W01G7.5 | |||||||
| Corresponding_transcript | W01G7.5.1 | ||||||||
| Other_sequence (19) | |||||||||
| Associated_feature | WBsf644830 | ||||||||
| WBsf658388 | |||||||||
| WBsf976399 | |||||||||
| WBsf976400 | |||||||||
| WBsf981354 | |||||||||
| WBsf990618 | |||||||||
| WBsf1013767 | |||||||||
| WBsf222419 | |||||||||
| WBsf222420 | |||||||||
| WBsf222421 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr9180 | ||||||||
| Expr10879 | |||||||||
| Expr11504 | |||||||||
| Expr12212 | |||||||||
| Expr1014258 | |||||||||
| Expr1031341 | |||||||||
| Expr1158080 | |||||||||
| Expr2013044 | |||||||||
| Expr2031276 | |||||||||
| Drives_construct | WBCnstr00018933 | ||||||||
| WBCnstr00020602 | |||||||||
| Construct_product | WBCnstr00001838 | ||||||||
| WBCnstr00017548 | |||||||||
| WBCnstr00018933 | |||||||||
| WBCnstr00020602 | |||||||||
| Regulate_expr_cluster | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated | ||||||||
| WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated | |||||||||
| WBPaper00044786:lem-2(tm1582)_downregulated | |||||||||
| WBPaper00044786:lem-2(tm1582)_upregulated | |||||||||
| Antibody | WBAntibody00000308 | ||||||||
| WBAntibody00000309 | |||||||||
| WBAntibody00000310 | |||||||||
| WBAntibody00000311 | |||||||||
| WBAntibody00001855 | |||||||||
| WBAntibody00002216 | |||||||||
| WBAntibody00002346 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (158) | |||||||||
| Interaction (35) | |||||||||
| Map_info | Map | II | Position | 22.3934 | Error | 0.004999 | |||
| Positive | Positive_clone | W01G7 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4984 | |||||||
| 4388 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00004339 | ||||||||
| WBPaper00005172 | |||||||||
| WBPaper00005828 | |||||||||
| WBPaper00017089 | |||||||||
| WBPaper00024687 | |||||||||
| WBPaper00025034 | |||||||||
| WBPaper00026102 | |||||||||
| WBPaper00026936 | |||||||||
| WBPaper00027235 | |||||||||
| WBPaper00027532 | |||||||||
| WBPaper00028456 | |||||||||
| WBPaper00028895 | |||||||||
| WBPaper00030590 | |||||||||
| WBPaper00032497 | |||||||||
| WBPaper00033439 | |||||||||
| WBPaper00035468 | |||||||||
| WBPaper00037942 | |||||||||
| WBPaper00038372 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00038510 | |||||||||
| WBPaper00038705 | |||||||||
| WBPaper00039053 | |||||||||
| WBPaper00040518 | |||||||||
| WBPaper00040826 | |||||||||
| WBPaper00041279 | |||||||||
| WBPaper00042675 | |||||||||
| WBPaper00042809 | |||||||||
| WBPaper00043784 | |||||||||
| WBPaper00044786 | |||||||||
| WBPaper00045548 | |||||||||
| WBPaper00046424 | |||||||||
| WBPaper00048349 | |||||||||
| WBPaper00048885 | |||||||||
| WBPaper00049860 | |||||||||
| WBPaper00051896 | |||||||||
| WBPaper00052080 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00059378 | |||||||||
| WBPaper00059881 | |||||||||
| WBPaper00062371 | |||||||||
| WBPaper00063976 | |||||||||
| WBPaper00064947 | |||||||||
| WBPaper00066335 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
