WormBase Tree Display for Gene: WBGene00002163

WBGene00002163 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: ist-1 Person_evidence: WBPerson545
      Sequence_name: C54D1.3
      Molecular_name (12)
      Other_name: CELE_C54D1.3 Accession_evidence: NDB BX284606
      Public_name: ist-1
    DB_info: Database: AceView gene XH757
        WormQTL gene WBGene00002163
        WormFlux gene WBGene00002163
        NDB locus_tag CELE_C54D1.3
        NCBI gene 180978
        RefSeq protein NM_001330903.3
            NM_001373346.3
            NM_001373345.2
            NM_076800.7
        TrEMBL UniProtAcc A0A4V0IIP8
            A0A4V0INB3
            Q18820
            A0A1C3NSK8
        UniProt_GCRP UniProtAcc A0A4V0IIP8
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 01 Jul 2016 14:56:15 WBPerson1983 Event: Acquires_merge: WBGene00044576
      Acquires_merge: WBGene00044576
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ist
    Allele (233)
    Strain: WBStrain00033295
      WBStrain00037950
    RNASeq_FPKM (74)
    GO_annotation: 00062458
      00062459
      00062460
      00062461
      00062462
      00062463
    Ortholog (28)
    Structured_description: Concise_description: ist-1 encodes a pleckstrin homology (PH) and phosphotyrosine binding (PTB) domain-containing insulin receptor substrate (IRS) homolog that negatively regulates lifespan and dauer development; IST-1 potentiates insulin-like signaling, although it is not absolutely required for such signaling under most conditions; in addition to acting through the AGE-1/PI3K branch of the insulin-like signaling pathway, IST-1 may also function in a parallel pathway to activate downstream protein-kinase Bs encoded by akt-1 and akt-2. Paper_evidence: WBPaper00005614
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable insulin receptor binding activity; phosphatidylinositol 3-kinase binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in dauer larval development; insulin receptor signaling pathway; and short-term memory. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C54D1.3b
      C54D1.3c
      C54D1.3d
      C54D1.3e
    Corresponding_CDS_history: C54D1.3:wp128
      C54D1.3b:wp271
      C54D1.3c:wp271
    Corresponding_transcript: C54D1.3b.1
      C54D1.3c.1
      C54D1.3d.1
      C54D1.3e.1
    Other_sequence: Tcir_isotig31452
      Tcir_isotig15722
    Associated_feature (14)
  Experimental_info: RNAi_result (12)
    Expr_pattern: Expr1012662
      Expr1025581
      Expr1031266
      Expr1146049
      Expr1147097
      Expr2012871
      Expr2031105
    Drives_construct: WBCnstr00023456
      WBCnstr00036412
    Construct_product: WBCnstr00023456
      WBCnstr00036412
    Microarray_results (28)
    Expression_cluster: WBPaper00032976:dosage_compensated_genes
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040560:hpl-2_embryo_downregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045316:prg-1_upregulated_L4
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Gender_Neutral
      WBPaper00045861:ash-2(tm1095)_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048690:gonad-male-biased
      WBPaper00048690:hermaphrodite-Z1-Z4_enriched
      WBPaper00048690:male-Z1-Z4_enriched
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:daf-16(mu86)_downregulated_neuron
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049377:MWCNT_downregulated
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055897:heat-shock_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056218:daf-16(mu86)_upregulated_Day3
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057254:MWCNT_upregulated_mRNA
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00061203:let-418(n3536)_downregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061340:ADF_AWB
      WBPaper00061340:ASE
      WBPaper00061340:ASG
      WBPaper00061340:ASG_AWA
      WBPaper00061340:RIC
      WBPaper00061405:S.aureus_downregulated_starvation
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061479:hda-1(ne4748)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061527:T16H12.9-kin-9_20752
      WBPaper00061651:ASEL_enriched
      WBPaper00061651:ASER_enriched
      WBPaper00061651:AWC_OFF_enriched
      WBPaper00061651:BAG_enriched
      WBPaper00061651:PVT_enriched
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061902:camt-1(ok515)_regulated_AFD
      WBPaper00062103:neuron_enriched
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065158:AFD_enriched
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065841:35_0
      WBPaper00065841:35_1
      WBPaper00065841:35_2
      WBPaper00065841:35_3
      WBPaper00065841:35_4
      WBPaper00065841:48_0
      WBPaper00065841:63_0
      WBPaper00065841:71_0
      WBPaper00065841:76_0
      WBPaper00065841:85_0
      WBPaper00065841:90_0
      WBPaper00065841:92_0
      WBPaper00065841:97_0
      WBPaper00065841:100_0
      WBPaper00065841:122_0
      WBPaper00065841:131_0
      WBPaper00065841:138_0
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_8
      cgc4489_group_18
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00024671:AFD_vs_AWB_upregulated
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028482:PA14_upregulated
      WBPaper00029437:rde-4_upregulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00032948:StarveUp2
      WBPaper00034739:N2moreDR1350
      WBPaper00035227:heat_shock_regulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc6390]:Cluster_B
    Interaction (12)
  Map_info (3)
  Reference (13)
  Remark: Sequence connection from [Wolkow C]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene