WormBase Tree Display for Gene: WBGene00002069

WBGene00002069 SMap: S_parent: Sequence: C04F12
  Identity: Version: 1
    Name: CGC_name: ikb-1 Person_evidence: WBPerson1122
      Sequence_name: C04F12.3
      Molecular_name: C04F12.3
        C04F12.3.1
        CE19676
      Other_name: CELE_C04F12.3 Accession_evidence: NDB BX284601
      Public_name: ikb-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ikb
    Allele (53)
    Possibly_affected_by: WBVar02153293
    Strain: WBStrain00029112
      WBStrain00051604
      WBStrain00051846
    RNASeq_FPKM (74)
    GO_annotation: 00018666
      00018667
      00018668
      00018669
      00018670
      00018671
      00018672
      00018673
      00109966
    Ortholog (33)
    Paralog: WBGene00006780 Caenorhabditis elegans From_analysis: Panther
      WBGene00012124 Caenorhabditis elegans From_analysis: Panther
      WBGene00011240 Caenorhabditis elegans From_analysis: Panther
      WBGene00007252 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: ikb-1 encodes an ortholog of human BCL3 (OMIM:109560) that physically interacts with the checkpoint protein MRT-2; ikb-1(nr2019) and ikb-1(nr2027) mutants display no obvious phenotype other than shortened lifespan; mutation of BCL3 is frequently associated with recurring translocations found in the neoplastic cells of patients with chronic lymphocytic leukemia, and has been implicated in cell cycle control (perhaps via apoptosis). Paper_evidence: WBPaper00004589
            WBPaper00004692
            WBPaper00005039
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable NF-kappaB binding activity. Involved in defense response to Gram-negative bacterium. Located in cytoplasm. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Is an ortholog of human NFKB2 (nuclear factor kappa B subunit 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0081152 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7795)
  Molecular_info: Corresponding_CDS: C04F12.3
    Corresponding_transcript: C04F12.3.1
    Other_sequence (38)
    Associated_feature: WBsf643607
      WBsf643608
      WBsf656781
      WBsf984774
      WBsf984775
      WBsf1010411
      WBsf1010412
      WBsf218325
  Experimental_info: RNAi_result: WBRNAi00002902 Inferred_automatically: RNAi_primary
      WBRNAi00114630 Inferred_automatically: RNAi_primary
      WBRNAi00028440 Inferred_automatically: RNAi_primary
      WBRNAi00039630 Inferred_automatically: RNAi_primary
      WBRNAi00091427 Inferred_automatically: RNAi_primary
      WBRNAi00075903 Inferred_automatically: RNAi_primary
      WBRNAi00067972 Inferred_automatically: RNAi_primary
      WBRNAi00001332 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9563
      Expr15289
      Expr1026817
      Expr1031222
      Expr1143726
      Expr2012714
      Expr2030950
    Drives_construct: WBCnstr00036478
    Construct_product: WBCnstr00014128
      WBCnstr00036478
    Regulate_expr_cluster: WBPaper00060445:ikb-1(nr2027)_downregulated_L1
      WBPaper00060445:ikb-1(nr2027)_downregulated_L4
      WBPaper00060445:ikb-1(nr2027)_upregulated_L1
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_downregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4
    Microarray_results (19)
    Expression_cluster: WBPaper00031132:LiCl_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044037:eat-2_regulated_nhr-62_dependent
      WBPaper00044037:eat-2_upregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:HgCl2_20uM_upregulated
      WBPaper00044557:DietaryRestriction_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00045521:Spermatogenic
      WBPaper00046121:mesoderm_unique
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046795:starvation_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048988:neuron_expressed
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049498:npr-1(ur89)_regulated_1
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_specific
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052856:Cadmium_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053664:ins-11(tm1053)_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Metformin_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060445:ikb-1(nr2027)_downregulated_L1
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_downregulated_L4
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:BWM_anterior
      WBPaper00061340:BWM_far_posterior
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061340:mu_int_mu_anal
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:nhr-18-C34D1.4_6256
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062354:H.zoospora_12h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065199:Transgeneration-starvation_regulated_fed
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11
      WBPaper00065841:1_1
      WBPaper00065841:4_0
      WBPaper00065841:4_1
      WBPaper00065841:4_2
      WBPaper00065841:7_0
      WBPaper00065841:7_1
      WBPaper00065841:7_2
      WBPaper00065841:7_3
      WBPaper00065841:7_4
      WBPaper00065841:24_0
      WBPaper00065841:24_1
      WBPaper00065841:26_0
      WBPaper00065841:26_2
      WBPaper00065841:38_0
      WBPaper00065841:38_2
      WBPaper00065841:38_3
      WBPaper00065841:110_0
      WBPaper00065841:110_1
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065995:M.humicola-extract_downregulated_N2
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4386_cluster_5_1
      cgc4489_group_15
      WBPaper00006465:II_ethanol_late_induction
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00027342:alpha-Synuclein(A53T)_downregulated
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_H
      WBPaper00037695:CC_3-day
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:kgb-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00044091:Bpseudomallei_induced_2h
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00050538:Fasting_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc6390]:Cluster_A
    Interaction (127)
    WBProcess: WBbiopr:00000039
  Map_info: Map: I Position: 3.85381 Error: 0.000485
    Positive: Positive_clone: C04F12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4781
    Pseudo_map_position
  Reference (18)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene