WormBase Tree Display for Gene: WBGene00001884

WBGene00001884 SMap: S_parent: Sequence: ZK131
  Identity: Version: 1
    Name: CGC_name: his-10 Person_evidence: WBPerson160
      Sequence_name: ZK131.4
      Molecular_name: ZK131.4
        ZK131.4.1
        CE03252
      Other_name: CELE_ZK131.4 Accession_evidence: NDB BX284602
      Public_name: his-10
    DB_info: Database: AceView gene 2O114
        WormFlux gene WBGene00001884
        NDB locus_tag CELE_ZK131.4
        NCBI gene 191671
        RefSeq protein NM_064492.1
        SwissProt UniProtAcc P62784
        UniProt_GCRP UniProtAcc P62784
        OMIM gene 602826
            602827
            602830
            602833
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: his
    Allele: WBVar01499702
      WBVar01498435
      WBVar01498941
    Legacy_information: [C.elegansII] NMK. Histone type H4. HIS3 cluster. [Roberts et al. 1989; EM]
    In_cluster: HIS3_cluster
    RNASeq_FPKM (74)
    GO_annotation: 00106118
      00106119
      00106120
      00109564
      00109565
      00109566
    Ortholog (89)
    Paralog (15)
    Structured_description: Concise_description: his-10 encodes an H4 histone. Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Involved in defense response to Gram-negative bacterium and innate immune response. Is an ortholog of several human genes including H4C1 (H4 clustered histone 1); H4C4 (H4 clustered histone 4); and H4C9 (H4 clustered histone 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: EFO:MONDO:0031400 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4785,HGNC:4787,HGNC:4790,HGNC:4793)
  Molecular_info: Corresponding_CDS: ZK131.4
    Corresponding_transcript: ZK131.4.1
    Other_sequence (15)
    Associated_feature: WBsf224211
  Experimental_info: RNAi_result (12)
    Expr_pattern: Expr1162652
    Drives_construct: WBCnstr00036627
    Construct_product: WBCnstr00036627
    Microarray_results: 190307_s_at
      Aff_ZK131.1
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032425:down_in_alg-1
      WBPaper00032425:down_in_lin-35
      WBPaper00032425:down_in_rde-4
      WBPaper00032425:down_in_zfp-1
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00040755:LRRK2(R1441C)-Tau_vs_N2_downregulated
      WBPaper00040755:LRRK2(R1441C)-Tau_vs_Tau_downregulated
      WBPaper00040755:LRRK2(wt)-Tau_vs_N2_downregulated
      WBPaper00040755:LRRK2(wt)-Tau_vs_Tau_downregulated
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045401:N.parisii_40h_upregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046741:Garlic-Extract_downregulated_mRNA
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:daf-2(e1370)_daf-16(mu86)_upregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049368:daf-2(e1370)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00051021:4-bromodiphenyl-ether_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00052885:hrde-1(tm1200)-emb-4(qm31)_regulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053368:F.oxysporum_regulated
      WBPaper00053771:up_at_3h-NaCl
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00055013:HMG-4_interacting_protein
      WBPaper00055060:flr-1(RNAi)_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00056900:PID-3_interacting
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056900:TOST-1_interacting
      WBPaper00056997:nmad-1(ok3133)_downregulated_germline_25C
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057196:raga-1(ok386)_upregulated)
      WBPaper00058942:henn-1(pk2295)_upregulated
      WBPaper00059254:PRG-1_interacting
      WBPaper00059328:mrps-5(RNAi)_upregulated_protein
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059605:simr-1(cmp36)_downregulated
      WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059739:hira-1(gk835598)_upregulated_L1
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00060764:swsn-1(os22ts)_downregulated
      WBPaper00060908:TEBP-1_interacting
      WBPaper00060908:TEBP-2_interacting
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061377:PAN-1_interacting
      WBPaper00061527:his-46_959-his-64
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062056:dpl-1(n2994)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00063976:micu-1(bon20)_downregulated
      WBPaper00064071:NHR-49_interacting
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064201:SNA-1_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064532:pals-22(jy3)_downregulated
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00065005:sams-3(RNAi)_upregulated
      WBPaper00065005:sams-4(RNAi)_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065995:M.humicola-extract_downregulated_N2
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:ash-2(RNAi)_upregulated_WT
      cgc4386_cluster_1_2
      WBPaper00025032:cluster_14
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00028789:PA14_vs_gacA_upregulated_8hr
      WBPaper00028789:PA14_vs_OP50_upregulated_4hr
      WBPaper00028789:PA14_vs_OP50_upregulated_8hr
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032948:FedUp
      WBPaper00034739:N2lessDR1350
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00037695:WC_CC_6-day
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00038427:lin-54_germline_changed
      WBPaper00039851:HK_C_albicans_vs_HK_OP50
      WBPaper00039851:Live_C_albicans_vs_HK_OP50
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040963:Q50_up
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00042178:hlh-29(tm284)_upregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045401:N.parisii_34h_upregulated_N2
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00050515:nipi-3(fr4)_upregulated
      WBPaper00050538:Fasting_upregulated
      [cgc5767]:cluster_10
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(83_min)
      [cgc5767]:expression_class_E_pi(41_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
    Interaction (261)
  Map_info: Map: II Position: 20.31
    Positive: Positive_clone: LCEH3
        ZK131 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: cannot be sequence C50F4.7 on V. removing [sdm 000920]
    cannot be sequence K03A1.6 on X. removing [sdm 000920]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene