WormBase Tree Display for Gene: WBGene00001699

WBGene00001699 Evidence: Paper_evidence: WBPaper00003717
    Person_evidence: WBPerson83
  SMap: S_parent: Sequence: F09D12
  Identity: Version: 1
    Name: CGC_name: grd-10 Person_evidence: WBPerson83
      Sequence_name: F09D12.1
      Molecular_name (3)
      Other_name: CELE_F09D12.1 Accession_evidence: NDB BX284604
      Public_name: grd-10
    DB_info: Database: AceView gene 4E207
        WormQTL gene WBGene00001699
        WormFlux gene WBGene00001699
        NDB locus_tag CELE_F09D12.1
        NCBI gene 184239
        RefSeq protein NM_067946.5
        TrEMBL UniProtAcc O44471
        UniProt_GCRP UniProtAcc O44471
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: grd
    Allele (20)
    Strain: WBStrain00002426
      WBStrain00002518
      WBStrain00002935
      WBStrain00032873
      WBStrain00032904
    RNASeq_FPKM (74)
    Ortholog (17)
    Paralog (24)
    Structured_description: Concise_description: grd-10 encodes a hedgehog-like protein, with an N-terminal signalsequence and a C-terminal Ground domain; GRD-10 is expressed in seamcells; the Ground domain is predicted to form a cysteine-crosslinkedprotein involved in intercellular signalling, and it has subtlesimilarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-10is weakly required for normal molting; GRD-10 is also required fornormal growth to full size and locomotion; all of these requirements mayreflect common defects in cholesterol-dependent hedgehog-like signallingor in vesicle trafficking. Paper_evidence: WBPaper00003717
            WBPaper00006525
            WBPaper00026841
            WBPaper00027263
          Curator_confirmed: WBPerson48
            WBPerson567
          Date_last_updated: 05 Nov 2006 00:00:00
      Automated_description: Enriched in several structures, including ABalppppaa; PLM; germ line; non-striated muscle; and somatic nervous system based on Chronogram; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and skn-1 based on microarray; tiling array; RNA-seq; and proteomic studies. Is affected by nineteen chemicals including nicotinic acid; rotenone; and D-glucose based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domain: Ground-like domain. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F09D12.1
    Corresponding_transcript: F09D12.1.1
    Other_sequence: JI218756.1
    Associated_feature: WBsf645874
      WBsf228101
  Experimental_info: RNAi_result: WBRNAi00044110 Inferred_automatically: RNAi_primary
      WBRNAi00030704 Inferred_automatically: RNAi_primary
      WBRNAi00076999 Inferred_automatically: RNAi_primary
      WBRNAi00077023 Inferred_automatically: RNAi_primary
      WBRNAi00012968 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1226
      Chronogram1444
      Expr4435
      Expr5697
      Expr1016283
      Expr1031014
      Expr1148078
      Expr2012224
      Expr2030460
    Drives_construct: WBCnstr00003037
      WBCnstr00004510
      WBCnstr00011998
      WBCnstr00036757
    Construct_product: WBCnstr00036757
    Microarray_results (17)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00027339:daf-12(rh273)_downregulated
      WBPaper00029359_1291
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040560:hpl-2_L3_downregulated
      WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
      WBPaper00044037:eat-2_upregulated
      WBPaper00044260:nicotinc-acid_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_upregulated
      WBPaper00049368:daf-2(e1370)_upregulated
      WBPaper00049417:B.animalis_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050096:P.aeruginosa_downregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050193:cec-4(ok3124)_downregulated_L1
      WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_adult_25C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050843:sesamin_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053771:down_by_skn-1(RNAi)_at_24h-NaCl
      WBPaper00053771:down_by_skn-1(RNAi)_at_dpy-7(e88)
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00054191:H3.3(null)_embryo_upregulated
      WBPaper00054191:H3.3(null)_L1_downregulated
      WBPaper00054410:set-9(rw5)_upregulated
      WBPaper00054410:set-26(tm2467)_upregulated
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00055013:hmg-4(RNAi)_upregulated
      WBPaper00055013:spt-16(RNAi)_upregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055060:flr-1(RNAi)_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055944:C.butyricum_vs_OP50_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056586:mpk-2(ok219)_upregulated
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00056617:adr-1_upregulated_L4_transcript
      WBPaper00056617:adr-2(gv42)_downregulated_L4_protein
      WBPaper00056900:TOFU-6_interacting
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058927:high-redox-state_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00059117:B.subtilis_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059735:glucose_downregulated_N2
      WBPaper00059895:wounding_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060526:plp-1(ok2155)_upregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061340:ADL_parent
      WBPaper00061340:ASE_parent
      WBPaper00061340:Seam_cell
      WBPaper00061377:PAN-1_interacting
      WBPaper00061405:S.aureus_downregulated_starvation
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:mup-2-unc-87_284
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061853:osm-3(dh441)_downregulated_tunicamycin
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062056:lin-15B(we23)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064122:vulva_transcriptome
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064494:postdauer_upregulated_AWA
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065272:dhgd-1(tm6671)_downregulated
      WBPaper00065315:mating_upregulated_Day2-7
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065623:34
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065841:0_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_transcript
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_2_6
      WBPaper00028789:PA14_vs_gacA_downregulated_4hr
      WBPaper00031832:slr-2_regulated
      WBPaper00032948:StarveUp1
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_C
      WBPaper00036464:S.aureus-RN6390_regulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00039866:ClassComp_daf-19_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040876:mir-35_downregulated
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_0.2mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00045015:nhr-25(RNAi)_downregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00046083:oga-1(ok1207)_OP50_upregulated
      WBPaper00046083:pmk-1(km25)_OP50_upregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
      WBPaper00053688:E.faecalis_downregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction: WBInteraction000309835
      WBInteraction000324733
      WBInteraction000424863
      WBInteraction000553089
      WBInteraction000561753
      WBInteraction000572731
    WBProcess: WBbiopr:00000123
  Map_info: Map: IV Position: -4.03129 Error: 0.029423
    Positive: Positive_clone: F09D12 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00003717
    WBPaper00026841
    WBPaper00028754
    WBPaper00031588
    WBPaper00042648
    WBPaper00061786
    WBPaper00064105
    WBPaper00065085
    WBPaper00065833
  Remark: grd-10 is paralogous to grd-5 Paper_evidence: WBPaper00003717
    grd-3, grd-10, and grd-13 form a cluster, grd-3 and grd-13 are paralogous to the grd-4 and grd-14 cluster Paper_evidence: WBPaper00003717
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene