gei-8 encodes a novel protein highly similar to C. briggsae BP:CBP04038 that contains a glutamine/asparagine (Q/N)-rich ('prion') domain (by the algorithm of Michelitsch and Weissman) and two myb-like DNA-binding domains; interacts with GEX-3 in yeast two-hybrid assays.
Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including anal depressor muscle; egg-laying apparatus; germ line; somatic nervous system; and tail ganglion. Human ortholog(s) of this gene implicated in Huntington's disease. Is an ortholog of human NCOR1 (nuclear receptor corepressor 1).
The pqn-12 gene was merged into this gene following advice from [Hodgkin J]. gei-8 was previously attached to C14B9.5 but this sequence was then merged into C14B9.6 to create a splice variant and this change has led to the two gene names being merged. [020621 krb]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.