| WBGene00001561 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | W07B3 |
| Identity | Version | 1 |
| | Name | CGC_name | gei-4 | Person_evidence | WBPerson1796 |
| | | Sequence_name | W07B3.2 |
| | | Molecular_name (22) |
| | | Other_name | W07B3.a | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | W07B3.b | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | CELE_W07B3.2 | Accession_evidence | NDB | BX284603 |
| | | Public_name | gei-4 |
| | DB_info | Database | AceView | gene | 3A962 |
| | | | WormQTL | gene | WBGene00001561 |
| | | | WormFlux | gene | WBGene00001561 |
| | | | NDB | locus_tag | CELE_W07B3.2 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001561|UniProtKB=H2L0F6 |
| | | | | family | PTHR22084 |
| | | | NCBI | gene | 175195 |
| | | | RefSeq | protein | NM_001393253.1 |
| | | | | | NM_001381690.2 |
| | | | | | NM_001384004.2 |
| | | | | | NM_001027640.5 |
| | | | | | NM_064789.6 |
| | | | | | NM_001393254.1 |
| | | | TREEFAM | TREEFAM_ID | TF319602 |
| | | | TrEMBL | UniProtAcc | H2L0F5 |
| | | | | | H2L0F8 |
| | | | | | H2L0F6 |
| | | | | | Q65CL5 |
| | | | | | Q8ITW3 |
| | | | | | H2L0F7 |
| | | | UniProt_GCRP | UniProtAcc | H2L0F6 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | gei |
| | Allele (233) |
| | Strain | WBStrain00037773 |
| | | WBStrain00037797 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00023031 |
| | | 00023032 |
| | | 00023033 |
| | | 00023034 |
| | | 00023035 |
| | | 00023036 |
| | Contained_in_operon | CEOP3023 |
| | Ortholog (29) |
| | Paralog | WBGene00021756 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00021986 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | gei-4 encodes a protein with a coiled-coil domain (predicted to mediate protein-protein interactions), an internal repeat of 69 residues (covering residues 134-202, 203-265, and 266-328 of W07B3.2a), and a glutamine/asparagine-rich domain; GEI-4 is paralogous to Y50D7A.8 and Y59C2A.3, physically interacts with GEX-2, and is required for embryonic viability, fertility, and vulval morphogenesis; GEI-4 is claimed to have weak homology to trichohyalin, a mammalian intermediate filament interacting protein; the similarity of the mutant phenotypes of gei-4, gex-2 and gex-3 and their interaction sugggest that the GEX-2/GEX-3/GEI-4 protein complex is essential for the regulation of intermediate filaments during rearrangement of the cytoskeleton that occurs in embryogenesis; GFI-2, an ankyrin-repeat protein associates with GEI-4 and exhibits a similar mutant phenotype, suggesting that gfi-2 is also involved in intermediate filament dynamics. | Paper_evidence | WBPaper00005068 |
| | | | | | WBPaper00005194 |
| | | | | | WBPaper00005654 |
| | | | | | WBPaper00012788 |
| | | | | | WBPaper00012830 |
| | | | | | WBPaper00012882 |
| | | | | | WBPaper00012897 |
| | | | | | WBPaper00013003 |
| | | | | | WBPaper00018044 |
| | | | | | WBPaper00018124 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Involved in negative regulation of Ras protein signal transduction and negative regulation of vulval development. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | W07B3.2a |
| | | W07B3.2b |
| | | W07B3.2c |
| | | W07B3.2d |
| | | W07B3.2e |
| | | W07B3.2f |
| | Corresponding_CDS_history | W07B3.2c:wp102 |
| | | W07B3.2d:wp187 |
| | Corresponding_transcript | W07B3.2a.1 |
| | | W07B3.2a.2 |
| | | W07B3.2b.1 |
| | | W07B3.2b.2 |
| | | W07B3.2c.1 |
| | | W07B3.2c.2 |
| | | W07B3.2d.1 |
| | | W07B3.2d.2 |
| | | W07B3.2e.1 |
| | | W07B3.2f.1 |
| | Other_sequence (51) |
| | Associated_feature (20) |
| Experimental_info | RNAi_result (38) |
| | Expr_pattern | Expr1017902 |
| | | Expr1030931 |
| | | Expr1158474 |
| | | Expr2012015 |
| | | Expr2030251 |
| | Microarray_results (59) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00034761:hlh-30_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_upregulated_protein |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049217:DAF-16_upregulated |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050514:CEBP-1_interacting |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00056139:gut-microbiota_downregulated |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00058691:CFP-1_interacting_protein |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00059194:KLF-1_interacting |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059754:E.faecalis_OG1RF_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061527:chd-7_16664-jmjd-3.1 |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061753:csr-1(tor159)_downregulated_20C |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00065995:M.humicola-extract_downregulated_N2 |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00025032:cluster_7 |
| | | WBPaper00025032:cluster_17 |
| | | WBPaper00025032:cluster_45 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00030985:Erwinia_carotovora_upregulated |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040963:TA200_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042274:tbx-2(bx59)_downregulated |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00050538:Fasting_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(122_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_E_pi(101_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SET |
| | | [cgc5767]:expression_class_SE_pi(53_min) |
| | | [cgc5767]:expression_class_SE_pi(101_min) |
| | Interaction (230) |
| Map_info | Map | III | Position | -26.893 | Error | 0.002195 |
| | Positive | Positive_clone | W07B3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (11) |
| Remark | Sequence connection from [Qadota H, Kaibuchi K] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
