WormBase Tree Display for Gene: WBGene00001475

WBGene00001475 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 2
    Name: CGC_name: fmi-1 Person_evidence: WBPerson194
            WBPerson481
      Sequence_name: F15B9.7
      Molecular_name: F15B9.7a
        F15B9.7a.1
        CE42459
        F15B9.7b
        CE50507
        F15B9.7c
        CE50392
        F15B9.7b.1
        F15B9.7c.1
      Other_name: cdh-6 Person_evidence: WBPerson698
        CELE_F15B9.7 Accession_evidence: NDB BX284605
      Public_name: fmi-1
    DB_info: Database: AceView gene 5N513
        WormQTL gene WBGene00001475
        WormFlux gene WBGene00001475
        NDB locus_tag CELE_F15B9.7
        Panther gene CAEEL|EnsemblGenome=WBGene00001475|UniProtKB=G5EDK5
          family PTHR24026
        NCBI gene 179788
        RefSeq protein NM_001313143.3
            NM_001313142.3
            NM_073855.6
        SwissProt UniProtAcc G5EDK5
        UniProt_GCRP UniProtAcc G5EDK5
        OMIM gene 604523
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 30 Sep 2009 14:20:01 WBPerson1847 Event: Acquires_merge: WBGene00000398
      Acquires_merge: WBGene00000398
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: fmi
    Allele (194)
    Strain: WBStrain00040023
      WBStrain00040028
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog: WBGene00059003 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00031034 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00031045 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00120528 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00192837 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00191295 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00031032 Caenorhabditis briggsae From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00223645 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2219 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g5182 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g20117 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g3097 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g19127 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g3300 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g8244 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g2745 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g8354 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g9503 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_03663.g18274 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-fmi-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold461.g1473 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00739.g14996 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_07667 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_017674 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g08987 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g24200 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50274700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g16161 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00242520 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00093765 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00268158 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00302867 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0024836 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030616-78 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-050823-4 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070122-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070122-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:3230 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:3231 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:1850 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1100883 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1858235 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1858236 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:69237 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:621787 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1560078 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00017576 Caenorhabditis elegans From_analysis: Panther
      WBGene00001980 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022103 Caenorhabditis elegans From_analysis: Panther
      WBGene00014914 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: fmi-1 encodes a highly conserved cadherin-like protein with unique domain composition of six EGF and two laminin G domains, a GPS cleavage site and seven-pass transmembrane domain; fmi-1 plays a crucial role in pioneer axon navigation as well as pioneer-mediated follower navigation; FMI-1 is required cell autonomously in pioneer and partially non-cell autonomously in the follower; different domains of FMI-1 are required for pioneer and follower navigation; mutations in fmi-1 cause strong axon navigation defects of VNC pioneer axons; HSN axons are more susceptible to changes in fmi-1 protein; LIN-17/frizzled functions together with fmi-1 in follower axon navigation; in addition, FMI-1 functions together with the CDH-4 cadherin to regulate GABAergic neuronal development; FMI-1 is expressed in neurons and localized to pioneer and follower axons during and after nervous system development; in the embryos FMI-1::GFP is found in axons in the nerve ring, the tail and along the dendrites of sensory neurons. Paper_evidence: WBPaper00037648
            WBPaper00040906
          Curator_confirmed: WBPerson12884
            WBPerson1843
          Date_last_updated: 05 Jul 2012 00:00:00
      Automated_description: Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in anterior/posterior axon guidance and interneuron axon guidance. Located in axon. Expressed in nervous system and somatic nervous system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Is an ortholog of human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050580 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1850)
  Molecular_info: Corresponding_CDS: F15B9.7a
      F15B9.7b
      F15B9.7c
    Corresponding_CDS_history: F15B9.7:wp138
      F15B9.7:wp188
    Corresponding_transcript: F15B9.7a.1
      F15B9.7b.1
      F15B9.7c.1
    Other_sequence: CRC05304_1
      JI163786.1
      JI163891.1
      CR04693
      JI163835.1
      JI163797.1
    Associated_feature (36)
  Experimental_info: RNAi_result: WBRNAi00066947 Inferred_automatically: RNAi_primary
      WBRNAi00001265 Inferred_automatically: RNAi_primary
      WBRNAi00101845 Inferred_automatically: RNAi_primary
      WBRNAi00044701 Inferred_automatically: RNAi_primary
      WBRNAi00000627 Inferred_automatically: RNAi_primary
      WBRNAi00013361 Inferred_automatically: RNAi_primary
    Expr_pattern (13)
    Drives_construct (11)
    Construct_product (11)
    Antibody: WBAntibody00002321
    Microarray_results (19)
    Expression_cluster (286)
    Interaction (26)
    Anatomy_function: WBbtf0831
      WBbtf0832
  Map_info: Map: V Position: 4.81313 Error: 0.003033
    Positive: Positive_clone: F15B9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4295
        4482
  Reference (34)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene