WormBase Tree Display for Gene: WBGene00001475

WBGene00001475 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 2
    Name: CGC_name: fmi-1 Person_evidence: WBPerson194
            WBPerson481
      Sequence_name: F15B9.7
      Molecular_name: F15B9.7a
        F15B9.7a.1
        CE42459
        F15B9.7b
        CE50507
        F15B9.7c
        CE50392
        F15B9.7b.1
        F15B9.7c.1
      Other_name: cdh-6 Person_evidence: WBPerson698
        CELE_F15B9.7 Accession_evidence: NDB BX284605
      Public_name: fmi-1
    DB_info: Database: AceView gene 5N513
        WormQTL gene WBGene00001475
        WormFlux gene WBGene00001475
        NDB locus_tag CELE_F15B9.7
        Panther gene CAEEL|EnsemblGenome=WBGene00001475|UniProtKB=G5EDK5
          family PTHR24026
        NCBI gene 179788
        RefSeq protein NM_001313143.3
            NM_001313142.3
            NM_073855.6
        SwissProt UniProtAcc G5EDK5
        UniProt_GCRP UniProtAcc G5EDK5
        OMIM gene 604523
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 30 Sep 2009 14:20:01 WBPerson1847 Event: Acquires_merge: WBGene00000398
      Acquires_merge: WBGene00000398
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: fmi
    Allele: WBVar01058737
      WBVar01058738
      WBVar01058739
      WBVar01058740
      WBVar01058741
      WBVar01058742
      WBVar01058743
      WBVar01058744
      WBVar00296809
      WBVar00296810
      WBVar01058745
      WBVar01058746
      WBVar00296811
      WBVar01058747
      WBVar00296812
      WBVar01058748
      WBVar00296813
      WBVar01058749
      WBVar01058750
      WBVar01058751
      WBVar01058752
      WBVar01058753
      WBVar01058754
      WBVar01058755
      WBVar01058756
      WBVar01058757
      WBVar01058758
      WBVar01058759
      WBVar01058760
      WBVar01058761
      WBVar00258017
      WBVar01058762
      WBVar00258019
      WBVar01058763
      WBVar01058764
      WBVar00249354
      WBVar01058765
      WBVar01058766
      WBVar01058767
      WBVar01058768
      WBVar01823786
      WBVar00253422
      WBVar01058769
      WBVar00253423
      WBVar01058770
      WBVar01058771
      WBVar01058772
      WBVar01058773
      WBVar01058774
      WBVar01484833
      WBVar01058775
      WBVar01058776
      WBVar01058777
      WBVar01058778
      WBVar01058779
      WBVar01058780
      WBVar01058781
      WBVar01058782
      WBVar01058783
      WBVar01743817
      WBVar01743818
      WBVar01058784
      WBVar01743819
      WBVar01058785
      WBVar01743820
      WBVar01058786
      WBVar01058787
      WBVar01058788
      WBVar01058789
      WBVar01058790
      WBVar01058791
      WBVar01058792
      WBVar01058793
      WBVar01058794
      WBVar00590346
      WBVar01058795
      WBVar01058796
      WBVar00590348
      WBVar01058797
      WBVar01058798
      WBVar01058799
      WBVar01058800
      WBVar01058801
      WBVar01058802
      WBVar01491679
      WBVar01808920
      WBVar01808921
      WBVar01808922
      WBVar00264160
      WBVar01489494
      WBVar00474027
      WBVar00474028
      WBVar00474029
      WBVar00474030
      WBVar00474031
      WBVar00474032
      WBVar00474033
      WBVar01868827
      WBVar00474034
      WBVar01868828
      WBVar00474035
      WBVar01491347
      WBVar00474036
      WBVar01868829
      WBVar00474037
      WBVar01868830
      WBVar01868831
      WBVar00474038
      WBVar01868832
      WBVar00474039
      WBVar01868833
      WBVar00474040
      WBVar01868834
      WBVar00474041
      WBVar00474042
      WBVar01868835
      WBVar00474043
      WBVar01868836
      WBVar01868837
      WBVar00474044
      WBVar00474045
      WBVar01868838
      WBVar01868839
      WBVar00474046
      WBVar01868840
      WBVar00474047
      WBVar00474048
      WBVar01868841
      WBVar01868842
      WBVar00474049
      WBVar00474050
      WBVar01868843
      WBVar00474051
      WBVar01868844
      WBVar00474052
      WBVar01868845
      WBVar00474053
      WBVar01868846
      WBVar00474054
      WBVar01868847
      WBVar00474055
      WBVar00474056
      WBVar00474057
      WBVar02061653
      WBVar00474058
      WBVar02061654
      WBVar00474059
      WBVar00474060
      WBVar02061655
      WBVar00474061
      WBVar01786650
      WBVar01500212
      WBVar01500213
      WBVar02043663
      WBVar00265319
      WBVar01499299
      WBVar00257227
      WBVar00257228
      WBVar00257229
      WBVar00011585
      WBVar01058712
      WBVar00011590
      WBVar01590363
      WBVar02137361
      WBVar01058713
      WBVar01058714
      WBVar02137362
      WBVar01058715
      WBVar00011595
      WBVar01058716
      WBVar01058717
      WBVar01058718
      WBVar00011600
      WBVar01058719
      WBVar01058720
      WBVar01499316
      WBVar00011605
      WBVar01058721
      WBVar01058722
      WBVar01058723
      WBVar00011610
      WBVar01058724
      WBVar01058725
      WBVar01058726
      WBVar01058727
      WBVar01058728
      WBVar01058729
      WBVar01058730
      WBVar01058731
      WBVar01058732
      WBVar01058733
      WBVar01058734
      WBVar01058735
      WBVar01058736
    Strain: WBStrain00040023
      WBStrain00040028
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (46)
    Paralog: WBGene00017576 Caenorhabditis elegans From_analysis: Panther
      WBGene00001980 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022103 Caenorhabditis elegans From_analysis: Panther
      WBGene00014914 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: fmi-1 encodes a highly conserved cadherin-like protein with unique domain composition of six EGF and two laminin G domains, a GPS cleavage site and seven-pass transmembrane domain; fmi-1 plays a crucial role in pioneer axon navigation as well as pioneer-mediated follower navigation; FMI-1 is required cell autonomously in pioneer and partially non-cell autonomously in the follower; different domains of FMI-1 are required for pioneer and follower navigation; mutations in fmi-1 cause strong axon navigation defects of VNC pioneer axons; HSN axons are more susceptible to changes in fmi-1 protein; LIN-17/frizzled functions together with fmi-1 in follower axon navigation; in addition, FMI-1 functions together with the CDH-4 cadherin to regulate GABAergic neuronal development; FMI-1 is expressed in neurons and localized to pioneer and follower axons during and after nervous system development; in the embryos FMI-1::GFP is found in axons in the nerve ring, the tail and along the dendrites of sensory neurons. Paper_evidence: WBPaper00037648
            WBPaper00040906
          Curator_confirmed: WBPerson12884
            WBPerson1843
          Date_last_updated: 05 Jul 2012 00:00:00
      Automated_description: Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in anterior/posterior axon guidance and interneuron axon guidance. Located in axon. Expressed in nervous system and somatic nervous system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Is an ortholog of human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050580 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1850)
  Molecular_info: Corresponding_CDS: F15B9.7a
      F15B9.7b
      F15B9.7c
    Corresponding_CDS_history: F15B9.7:wp138
      F15B9.7:wp188
    Corresponding_transcript: F15B9.7a.1
      F15B9.7b.1
      F15B9.7c.1
    Other_sequence: CRC05304_1
      JI163786.1
      JI163891.1
      CR04693
      JI163835.1
      JI163797.1
    Associated_feature (36)
  Experimental_info: RNAi_result: WBRNAi00066947 Inferred_automatically: RNAi_primary
      WBRNAi00001265 Inferred_automatically: RNAi_primary
      WBRNAi00101845 Inferred_automatically: RNAi_primary
      WBRNAi00044701 Inferred_automatically: RNAi_primary
      WBRNAi00000627 Inferred_automatically: RNAi_primary
      WBRNAi00013361 Inferred_automatically: RNAi_primary
    Expr_pattern (13)
    Drives_construct (11)
    Construct_product (11)
    Antibody: WBAntibody00002321
    Microarray_results (19)
    Expression_cluster (286)
    Interaction (26)
    Anatomy_function: WBbtf0831
      WBbtf0832
  Map_info: Map: V Position: 4.81313 Error: 0.003033
    Positive: Positive_clone: F15B9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4295
        4482
  Reference (34)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene