WormBase Tree Display for Gene: WBGene00001430
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| WBGene00001430 | SMap | S_parent | Sequence | C50F2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | fkb-5 | Person_evidence | WBPerson466 | |||||
| Sequence_name | C50F2.6 | ||||||||
| Molecular_name | C50F2.6a | ||||||||
| C50F2.6a.1 | |||||||||
| CE08912 | |||||||||
| C50F2.6b | |||||||||
| CE27878 | |||||||||
| C50F2.6a.2 | |||||||||
| C50F2.6b.1 | |||||||||
| Other_name | dao-8 | Person_evidence | WBPerson2330 | ||||||
| CELE_C50F2.6 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | fkb-5 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fkb | ||||||||
| Allele (31) | |||||||||
| Strain | WBStrain00035794 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00050201 | ||||||||
| 00050202 | |||||||||
| 00050203 | |||||||||
| 00050204 | |||||||||
| 00050205 | |||||||||
| 00050206 | |||||||||
| 00050207 | |||||||||
| 00050208 | |||||||||
| 00108696 | |||||||||
| Contained_in_operon | CEOP1132 | ||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00001428 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001429 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001426 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001427 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001431 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001432 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001433 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | fkb-5 encodes a peptidyl-prolyl cis-trans isomerase (PPIase) that is one of eight FK506 binding proteins encoded by the C. elegans genome; although fkb-5 single mutants show no obvious defects, animals doubly and triply mutant for fkb-5 and other FKB secretory pathway mutants display synthetic, cold-sensitive body morphology and molting defects as well as L1 larval lethality; an fkb-5::lacZ reporter fusion is expressed in hypodermal cells, including lateral seam cells and tail and head hypodermal cells, from mid-embryogenesis through adulthood; fkb-5 transcript analysis shows that fkb-5 mRNA abundance is greatest at the inter-molt period of each larval stage and lower during molting and in adults; microarray studies indicate that fkb-5 transcript levels are reduced in a lin-14 loss-of-function background, suggesting that LIN-14 positively regulates fkb-5 expression. | Paper_evidence | WBPaper00026952 | |||||
| WBPaper00029155 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 22 Jan 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in endoplasmic reticulum. Expressed in hypodermis. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 11. Is an ortholog of human FKBP10 (FKBP prolyl isomerase 10) and FKBP9 (FKBP prolyl isomerase 9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110351 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18169) | ||||
| Molecular_info | Corresponding_CDS | C50F2.6a | |||||||
| C50F2.6b | |||||||||
| Corresponding_transcript | C50F2.6a.1 | ||||||||
| C50F2.6a.2 | |||||||||
| C50F2.6b.1 | |||||||||
| Other_sequence (107) | |||||||||
| Associated_feature | WBsf649061 | ||||||||
| WBsf649062 | |||||||||
| WBsf649063 | |||||||||
| WBsf664085 | |||||||||
| WBsf983267 | |||||||||
| WBsf219204 | |||||||||
| WBsf219205 | |||||||||
| WBsf219206 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00003212 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00030036 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042931 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116761 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070772 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070773 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076230 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065432 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8302 | ||||||||
| Expr8305 | |||||||||
| Expr16142 | |||||||||
| Expr1012660 | |||||||||
| Expr1030855 | |||||||||
| Expr1146900 | |||||||||
| Expr2011799 | |||||||||
| Expr2030037 | |||||||||
| Drives_construct | WBCnstr00013249 | ||||||||
| WBCnstr00036955 | |||||||||
| Construct_product | WBCnstr00013249 | ||||||||
| WBCnstr00036955 | |||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (295) | |||||||||
| Interaction (95) | |||||||||
| Map_info | Map | I | Position | -1.93089 | Error | 0.003402 | |||
| Positive | Positive_clone | C50F2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4309 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00004285 | ||||||||
| WBPaper00005073 | |||||||||
| WBPaper00017047 | |||||||||
| WBPaper00026884 | |||||||||
| WBPaper00026952 | |||||||||
| WBPaper00029155 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041179 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064339 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
