| WBGene00001402 | SMap | S_parent | Sequence | F21H12 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | fbf-2 | Person_evidence | WBPerson320 |
| | | Sequence_name | F21H12.5 |
| | | Molecular_name | F21H12.5 |
| | | | F21H12.5.1 |
| | | | CE01916 |
| | | Other_name | FBF2 | Paper_evidence | WBPaper00012973 |
| | | | FBF | Paper_evidence | WBPaper00053101 |
| | | | | | WBPaper00053705 |
| | | | CELE_F21H12.5 | Accession_evidence | NDB | BX284602 |
| | | Public_name | fbf-2 |
| | DB_info | Database | AceView | gene | 2G380 |
| | | | WormQTL | gene | WBGene00001402 |
| | | | WormFlux | gene | WBGene00001402 |
| | | | NDB | locus_tag | CELE_F21H12.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001402|UniProtKB=Q09312 |
| | | | | family | PTHR12537 |
| | | | NCBI | gene | 174017 |
| | | | RefSeq | protein | NM_001381445.2 |
| | | | SwissProt | UniProtAcc | Q09312 |
| | | | TREEFAM | TREEFAM_ID | TF318622 |
| | | | UniProt_GCRP | UniProtAcc | Q09312 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | fbf |
| | Allele (52) |
| | Legacy_information | [Gallegos M, Zhang B] fbf-2(RNAi) animals produce excess sperm and no oocytes (Mog phenotype). Encodes fem-3 PME RNA binding protein, 91% identical to FBF-1. Predicted gene F21H12.5 |
| | Strain | WBStrain00022611 |
| | | WBStrain00022612 |
| | | WBStrain00022628 |
| | | WBStrain00022640 |
| | | WBStrain00022665 |
| | | WBStrain00022345 |
| | | WBStrain00022394 |
| | | WBStrain00022449 |
| | RNASeq_FPKM (74) |
| | GO_annotation (13) |
| | Ortholog | WBGene00067518 | Caenorhabditis remanei | From_analysis | OMA |
| | | | | | Inparanoid_8 |
| | | WBGene00071258 | Caenorhabditis remanei | From_analysis | OMA |
| | | | | | Inparanoid_8 |
| | | WBGene00025706 | Caenorhabditis briggsae | From_analysis | OrthoMCL |
| | | | | | OMA |
| | | | | | Inparanoid_8 |
| | | WBGene00025707 | Caenorhabditis briggsae | From_analysis | OrthoMCL |
| | | WBGene00034222 | Caenorhabditis briggsae | From_analysis | OrthoMCL |
| | | | | | OMA |
| | | | | | Inparanoid_8 |
| | | WBGene00140206 | Caenorhabditis brenneri | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00153087 | Caenorhabditis brenneri | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00126052 | Caenorhabditis japonica | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00100824 | Pristionchus pacificus | From_analysis | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00224613 | Brugia malayi | From_analysis | WormBase-Compara |
| | | WBGene00227366 | Brugia malayi | From_analysis | WormBase-Compara |
| | | CBOVI.g5374 | Caenorhabditis bovis | From_analysis | WormBase-Compara |
| | | CSP21.g11873 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara |
| | | CSP21.g1934 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara |
| | | CSP28.g1402 | Caenorhabditis panamensis | From_analysis | WormBase-Compara |
| | | CSP29.g12484 | Caenorhabditis becei | From_analysis | WormBase-Compara |
| | | CSP32.g16457 | Caenorhabditis sulstoni | From_analysis | WormBase-Compara |
| | | CSP32.g16466 | Caenorhabditis sulstoni | From_analysis | WormBase-Compara |
| | | CSP38.g9345 | Caenorhabditis quiockensis | From_analysis | WormBase-Compara |
| | | CSP39.g9352 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara |
| | | Cang_2012_03_13_00025.g1524 | Caenorhabditis angaria | From_analysis | WormBase-Compara |
| | | Cang_2012_03_13_00094.g4173 | Caenorhabditis angaria | From_analysis | WormBase-Compara |
| | | Cang_2012_03_13_12998.g24025 | Caenorhabditis angaria | From_analysis | WormBase-Compara |
| | | Csp11.Scaffold629.g16434 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara |
| | | OTIPU.nOt.2.0.1.g02937 | Oscheius tipulae | From_analysis | WormBase-Compara |
| | | Pan_g1916 | Panagrellus redivivus | From_analysis | WormBase-Compara |
| | | Pan_g20286 | Panagrellus redivivus | From_analysis | WormBase-Compara |
| | | Sp34_20124000 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | chrII_pilon.g4684 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00245171 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00247535 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00280223 | Pristionchus pacificus | From_analysis | WormBase-Compara |
| | | WBGene00265279 | Strongyloides ratti | From_analysis | WormBase-Compara |
| | Paralog | WBGene00001401 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004239 | Caenorhabditis elegans | From_analysis | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00022257 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004241 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004243 | Caenorhabditis elegans | From_analysis | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004242 | Caenorhabditis elegans | From_analysis | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004240 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | WBGene00004244 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004245 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. | Paper_evidence | WBPaper00002949 |
| | | | | | WBPaper00005265 |
| | | | | | WBPaper00005566 |
| | | | | | WBPaper00006369 |
| | | | | | WBPaper00018711 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 24 Sep 2004 00:00:00 |
| | | Automated_description | Enables mRNA 3'-UTR binding activity. Involved in negative regulation of translation. Located in P granule. Used to study obesity. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 28 Jun 2022 00:00:00 |
| Models_disease_in_annotation | WBDOannot00001264 |
| Molecular_info | Corresponding_CDS | F21H12.5 |
| | Corresponding_transcript | F21H12.5.1 |
| | Other_sequence | EX544358.1 |
| | | Oden_isotig19477 |
| | | PP02603 |
| | | PPC01861_1 |
| | | EX564883.1 |
| | | GW916430.1 |
| | | CJC02888_1 |
| | Associated_feature | WBsf223129 |
| | Gene_product_binds | WBsf027922 |
| | | WBsf899551 |
| | | WBsf899552 |
| | | WBsf899553 |
| | | WBsf899554 |
| | Transcription_factor | WBTranscriptionFactor000103 |
| Experimental_info | RNAi_result (70) |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00005290 |
| | | WBCnstr00036968 |
| | Construct_product | WBCnstr00005274 |
| | | WBCnstr00015117 |
| | | WBCnstr00036968 |
| | | WBCnstr00040359 |
| | Regulate_expr_cluster | WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched |
| | | WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched |
| | Antibody | WBAntibody00000785 |
| | | WBAntibody00000965 |
| | | WBAntibody00001086 |
| | Microarray_results (16) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045050:drh-3 (ne4253)_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046691:P1_enriched |
| | | WBPaper00048611:MnCl2_downregulated |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_8 |
| | | WBPaper00049954:BPS_downregulated |
| | | WBPaper00050080:rbr-2(tm3141)_downregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053295:lin-22(icb38)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053321:lin-15B(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053599:mitosis_vs_meiosis_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00056165:mina-1(ok1521)_upregulated_transcript |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056809:smn-1(ok355)_downregulated |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_L1 |
| | | WBPaper00060100:SiNP_downregulated_mRNA |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00061340:Germline |
| | | WBPaper00061340:MC |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:pgl-1-wago-2 |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064107:lin-35(n745)_downregulated |
| | | WBPaper00064315:mes-4(bn73)_downregulated_EGCs |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065749:Heat-Shock_upregulated_N2 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00024393:strongly_regulated_dauer_genes |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00032165:A_to_C_transit_decreased |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_5 |
| | | WBPaper00032948:FedUp |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00036429:glp-1(oz112)_upregulated |
| | | WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated |
| | | WBPaper00037695:CC_3-day |
| | | WBPaper00038060:SUMO-1_upregulated |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00048624:hlh-25(ok1710)_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:intrinsic |
| | Interaction (93) |
| Map_info | Map | II | Position | -0.523905 | Error | 0.013695 |
| | Positive | Positive_clone | F21H12 | Author_evidence | (genome sequence, |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4304 |
| | | | 4305 |
| | | | 4907 |
| | Pseudo_map_position |
| Reference (136) |
| Picture | WBPicture0000013095 |
| Remark | Data extracted from Zhang et al. (1997) |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
