| WBGene00001396 | SMap | S_parent | Sequence | T13F2 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | fat-4 |
| | | Sequence_name | T13F2.1 |
| | | Molecular_name | T13F2.1a |
| | | | T13F2.1a.1 |
| | | | CE25113 |
| | | | T13F2.1b |
| | | | CE44752 |
| | | | T13F2.1c |
| | | | CE45810 |
| | | | T13F2.1b.1 |
| | | | T13F2.1c.1 |
| | | Other_name | CELE_T13F2.1 | Accession_evidence | NDB | BX284604 |
| | | Public_name | fat-4 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | fat |
| | Allele (39) |
| | Legacy_information | [Napier JA] No mutants known. Encodes predicted delta6 fatty acid desaturase, protein expressed in yeast confers ability to desaturate linoleic acid to gamma-linolenic acid. |
| | Strain | WBStrain00031739 |
| | | WBStrain00004009 |
| | | WBStrain00004013 |
| | RNASeq_FPKM (74) |
| | GO_annotation (18) |
| | Ortholog (38) |
| | Paralog | WBGene00001395 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | fat-4 encodes a delta-5 fatty acid desaturase; when expressed heterologously in S. cerevisiae, FAT-4 converts di-homo-gamma-linolenic acid (20:3delta8,11,14) to arachidonic acid (20:4delta5,8,11,14), an important precursor in eicosanoid metabolism, as well as on other fatty acids (C18 to C20); FAT-4 is is required in vivo for delta-5 unsaturated fatty acid synthesis. | Paper_evidence | WBPaper00003387 |
| | | | | | WBPaper00003999 |
| | | | | | WBPaper00005233 |
| | | | | | WBPaper00013538 |
| | | | | | WBPaper00013550 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables stearoyl-CoA 9-desaturase activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Expressed in nerve ring and touch receptor neurons. Used to study alcohol use disorder. Is an ortholog of human FADS1 (fatty acid desaturase 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045655 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 05 Jun 2019 00:00:00 |
| Models_disease_asserted | WBDOannot00000698 |
| Molecular_info | Corresponding_CDS | T13F2.1a |
| | | T13F2.1b |
| | | T13F2.1c |
| | Corresponding_transcript | T13F2.1a.1 |
| | | T13F2.1b.1 |
| | | T13F2.1c.1 |
| | Other_sequence (42) |
| | Associated_feature | WBsf660530 |
| | | WBsf978988 |
| | | WBsf228877 |
| Experimental_info | RNAi_result (13) |
| | Expr_pattern | Expr11477 |
| | | Expr1017191 |
| | | Expr1030836 |
| | | Expr1156851 |
| | | Expr2011437 |
| | | Expr2029675 |
| | Drives_construct | WBCnstr00019043 |
| | | WBCnstr00036973 |
| | Construct_product | WBCnstr00036973 |
| | Microarray_results (27) |
| | Expression_cluster | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:excretory-cell_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_larva_enriched |
| | | WBPaper00037950:intestine_CoreEnriched |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:intestine_larva_enriched |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00038168:lin-15B(n744)_downregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00045842:elt-2_dependent_hypoxia_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_downregulated_protein |
| | | WBPaper00046795:starvation_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048926:miaserin_upregulated_adult-day5 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051311:VGLN-1-interacting |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00052987:UV_downregulated_xpc-1;csb-1 |
| | | WBPaper00053039:Aspirin_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056809:smn-1(ok355)_downregulated |
| | | WBPaper00057041:spc-1(cas971)_downregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059253:stearic-acid_upregulated |
| | | WBPaper00059253:sucrose_stearic-acid_upregulated |
| | | WBPaper00059253:sucrose_upregulated |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061340:ABarpaaa_lineage |
| | | WBPaper00061340:AMso_parent |
| | | WBPaper00061340:I2_grandparent |
| | | WBPaper00061340:Neuroblast_AFD_RMD |
| | | WBPaper00061340:Neuroblast_ASG_AWA |
| | | WBPaper00061340:Parent_of_tail_spike_and_hyp10 |
| | | WBPaper00061340:rect_D |
| | | WBPaper00061340:RIM_parent |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061527:dld-1-skn-1_16701 |
| | | WBPaper00061651:RIA_enriched |
| | | WBPaper00061651:XXX_enriched |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062237:dnj-21(RNAi)_downregulated_protein |
| | | WBPaper00062293:clk-1(qm30)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062456:doxycycline_upregulated_CB4856_protein |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064539:nhr-114(gk849)_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064789:Day3_vs_Day1_downregulated_neuron |
| | | WBPaper00064789:Day6_vs_Day1_downregulated_neuron |
| | | WBPaper00064789:Day9_vs_Day1_downregulated_neuron |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065841:83_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4386_cluster_1_3 |
| | | cgc4489_group_12 |
| | | WBPaper00005124:estrogen_10-5M_regulated |
| | | WBPaper00005124:progesterone_10-7M_regulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031184:acrylamide_downregulated |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00032948:StarveUp3 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_D |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042178:hlh-29(tm284)_upregulated |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00044091:Bpseudomallei_repressed_12h |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(41_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (168) |
| | WBProcess | WBbiopr:00000121 |
| Map_info | Map | IV | Position | 4.4198 | Error | 0.00065 |
| | Positive | Positive_clone | T13F2 | Person_evidence | WBPerson681 |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4299 |
| | | | 4300 |
| | Pseudo_map_position |
| Reference (45) |
| Remark | Extracted from Napier et al. (1998), fat-4 assigned as gene name. |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
