WormBase Tree Display for Gene: WBGene00001395
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| WBGene00001395 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | fat-3 | |||||||
| Sequence_name | W08D2.4 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_W08D2.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | fat-3 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fat | ||||||||
| Allele (56) | |||||||||
| Legacy_information | [Barnes TM] fat for FATty acid metabolism. Encodes predicted enzyme for beta-oxidation of fatty acids. Predicted gene C17G10.8 | ||||||||
| Strain | WBStrain00036068 | ||||||||
| WBStrain00004012 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00001396 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | fat-3 encodes a delta-6 fatty acid desaturase ('linoleoyl-CoA desaturase') containing an N-terminal cytochrome b5 domain that is orthologous to the vertebrate fatty acid desaturases (FADS); FAT-3 expressed in yeast uses linoleic and alpha-linolenic acid as substrates; FAT-3 is absolutely required in vivo for synthesis of delta-6 fatty acids, and also required for fully normal synthesis of C20 fatty acids; FAT-3 is required for a normally fast growth rate and movement speed, and for normal defecation rhythms and fertility; fat-3 is also required for regulation of basal innate immunity. | Paper_evidence | WBPaper00003032 | |||||
| WBPaper00003387 | |||||||||
| WBPaper00003999 | |||||||||
| WBPaper00005233 | |||||||||
| WBPaper00005728 | |||||||||
| WBPaper00013538 | |||||||||
| WBPaper00013550 | |||||||||
| WBPaper00013584 | |||||||||
| WBPaper00032370 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 16 May 2014 00:00:00 | ||||||||
| Automated_description | Enables stearoyl-CoA 9-desaturase activity. Involved in several processes, including egg-laying behavior; signal release; and system process. Predicted to be located in membrane. Expressed in body wall musculature; head neurons; intestine; pharynx; and tail neurons. Used to study alcohol use disorder and lipid metabolism disorder. Is an ortholog of human FADS2 (fatty acid desaturase 2) and FADS3 (fatty acid desaturase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045655 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Jun 2019 00:00:00 | ||||||||
| DOID:3146 | Homo sapiens | Paper_evidence | WBPaper00060352 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Jan 2021 00:00:00 | ||||||||
| Potential_model | DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3575) | |||||
| Models_disease_asserted | WBDOannot00000699 | ||||||||
| WBDOannot00000845 | |||||||||
| Molecular_info | Corresponding_CDS | W08D2.4a | |||||||
| W08D2.4b | |||||||||
| W08D2.4c | |||||||||
| W08D2.4d | |||||||||
| Corresponding_transcript | W08D2.4a.1 | ||||||||
| W08D2.4b.1 | |||||||||
| W08D2.4c.1 | |||||||||
| W08D2.4d.1 | |||||||||
| Other_sequence (97) | |||||||||
| Associated_feature | WBsf646256 | ||||||||
| WBsf660531 | |||||||||
| WBsf660532 | |||||||||
| WBsf978983 | |||||||||
| WBsf228878 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr2386 | ||||||||
| Expr1028132 | |||||||||
| Expr1030835 | |||||||||
| Expr1158509 | |||||||||
| Expr2011436 | |||||||||
| Expr2029674 | |||||||||
| Drives_construct | WBCnstr00010806 | ||||||||
| WBCnstr00019118 | |||||||||
| WBCnstr00036974 | |||||||||
| Construct_product | WBCnstr00010806 | ||||||||
| WBCnstr00036974 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (224) | |||||||||
| Interaction (172) | |||||||||
| Anatomy_function | WBbtf0243 | ||||||||
| WBbtf0244 | |||||||||
| WBbtf0245 | |||||||||
| WBbtf0246 | |||||||||
| WBbtf0247 | |||||||||
| WBbtf0248 | |||||||||
| WBbtf0249 | |||||||||
| WBProcess | WBbiopr:00000002 | ||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000121 | |||||||||
| Map_info | Map | IV | Position | 4.42122 | Error | 0.000463 | |||
| Positive | Positive_clone | W08D2 | Person_evidence | WBPerson681 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4299 | |||||||
| 4300 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (82) | |||||||||
| Remark | C17G10.8 link removed by agreement [sdm 0107] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
