fat-2 encodes a delta-12 fatty acyl desaturase that increases membranefluidity when expressed in yeast, and that may protect against coldstress; FAT-2's substrate is unknown, but may be acyl-CoA; FAT-2 isrequired in vivo for normal levels of C18 or C20 polyunsaturated fattyacids (PUFAs); FAT-2 is fully required for a sperm-attracting cue(perhaps an eicosanoid) secreted by oocytes, and partially required forthe polarizing activity of PAR-3, PAR-6, and other proteins; FAT-2 isalso required for a normally fast growth rate and movement rate, and fornormal body shape, defecation rhythm, and brood size; when expressed in yeast, FAT-2 exhibits a v+3 mode of desaturase activity, catalyzing double bond formation three carbons from an existing double bond.
Enables stearoyl-CoA 9-desaturase activity. Involved in several processes, including collagen and cuticulin-based cuticle development; fatty acid biosynthetic process; and innate immune response. Predicted to be located in membrane.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.