WormBase Tree Display for Gene: WBGene00001393
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| WBGene00001393 | SMap | S_parent | Sequence | Y67H2A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | fat-1 | |||||||
| Sequence_name | Y67H2A.8 | ||||||||
| Molecular_name | Y67H2A.8 | ||||||||
| Y67H2A.8.1 | |||||||||
| CE22790 | |||||||||
| Other_name | CELE_Y67H2A.8 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | fat-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fat | ||||||||
| Allele (91) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes fatty acid desaturase (EST cm10e11), complements Arabidopsis mutant fad2 (deficient in 18:3 fatty acid synthesis). [CGC] | ||||||||
| Strain | WBStrain00032486 | ||||||||
| WBStrain00004010 | |||||||||
| WBStrain00004013 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (30) | |||||||||
| Paralog | WBGene00001394 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | fat-1 encodes an omega-3 fatty acyl desaturase that acts onsubstrates of 16-20 carbons with a preference for omega-6 fatty acids;FAT-1 dehydrogenates its substrates 3 carbons from the methyl terminus;FAT-1 is required in vivo for n3 polyunsaturated fatty acid (PUFA)synthesis; the fatty acids of fat-1(wa9) mutants consist of 20%arachidonic acid (20:4n6), instead of the 20% eicosapentaenoic acid(20:5n3) seen in wild-type worms; fat-1(wa9) mutants are generallynormal, with normal chemotaxis; fat-4(wa14) fat-1(wa9) double mutantsare superficially normal but have deficient chemotaxis to AWA-sensedodorants (though not to AWC-sensed ones), and mildly defectiveOSM-9/OCR-2-dependent nociception by ASH neurons; fat-1 mutants areabnormally sensitive to excess dihommogamma-linolenic acid (DGLA,20:3n-6), which induces degeneration of larval germ cells, excessapoptosis in adult germline, and sterility; while this sensitivity isenhanced by fat-4 mutations, it requires excess DGLA (or its precursor,gamma-linolenic acid/18:3n-6) in the food media; fat-1 or fat-1;fat-4mutants grown on normal food are fertile, despite their having excessDGLA in vivo; transgenic FAT-1 can lower apoptosis in cultured mammalianneurons, suggesting that it may be required for an evolutionarilyconserved signalling pathway regulating apoptosis. | Paper_evidence (11) | ||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 10 Jun 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable oxidoreductase activity. Involved in positive regulation of locomotion and unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Expressed in intestine; nerve ring; and touch receptor neurons. Used to study alcohol use disorder. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045655 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jun 2019 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000709 | ||||||||
| Molecular_info | Corresponding_CDS | Y67H2A.8 | |||||||
| Corresponding_transcript | Y67H2A.8.1 | ||||||||
| Other_sequence (29) | |||||||||
| Associated_feature | WBsf716796 | ||||||||
| WBsf981840 | |||||||||
| WBsf998378 | |||||||||
| WBsf998379 | |||||||||
| WBsf229415 | |||||||||
| WBsf229416 | |||||||||
| WBsf229417 | |||||||||
| WBsf229418 | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern | Expr11476 | ||||||||
| Expr1014973 | |||||||||
| Expr1030833 | |||||||||
| Expr1161435 | |||||||||
| Expr2011434 | |||||||||
| Expr2029672 | |||||||||
| Drives_construct | WBCnstr00019042 | ||||||||
| WBCnstr00036976 | |||||||||
| Construct_product | WBCnstr00036976 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (195) | |||||||||
| Interaction (19) | |||||||||
| WBProcess | WBbiopr:00000121 | ||||||||
| Map_info | Map | IV | Position | 8.5225 | Error | 0.002181 | |||
| Positive | Positive_clone | Y67H2A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4297 | |||||||
| 4298 | |||||||||
| 5570 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (63) | |||||||||
| Remark | information received from Spychalla (Madison, John Browse lab) 02/95. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
