WormBase Tree Display for Gene: WBGene00001371

WBGene00001371 Evidence: Person_evidence: WBPerson260
  SMap: S_parent: Sequence: F26H11
  Identity: Version: 1
    Name: CGC_name: exl-1 Person_evidence: WBPerson260
      Sequence_name: F26H11.5
      Molecular_name: F26H11.5
        F26H11.5.1
        CE24922
      Other_name: CELE_F26H11.5 Accession_evidence: NDB BX284602
      Public_name: exl-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: exl
    Allele (33)
    Strain: WBStrain00031671
    RNASeq_FPKM (74)
    GO_annotation (29)
    Ortholog: WBGene00070590 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00032289 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00156266 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00139352 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00160234 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00136544 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00206983 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00060842 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00223904 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g6799 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g5622 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g18284 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g1394 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g17375 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g24401 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g6302 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g21972 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g1435 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g18312 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00049.g2588 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-exl-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g15679 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00601.g13403 Caenorhabditis sinica From_analysis: WormBase-Compara
      GCK72_004345 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10947 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g14668 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20165900 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g6535 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00248140 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00266719 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00292832 Trichuris muris From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-030131-3202 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030326-3 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2542 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040718-299 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-041114-84 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:2063 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:13518 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:2065 Homo sapiens From_analysis: OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:1352754 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1916704 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1917912 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:61857 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:620659 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1306580 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1307249 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1303043 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00001365 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001790 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001791 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001792 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00008920 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015337 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016204 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019636 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021817 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00043097 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: exl-1 encodes a putative chloride intracellular channel (CLIC) paralogous to EXC-4; transgenic EXL-1 can partially rescue the exc-4(rh133) mutant phenotype when its expression is driven with an exc-4 promoter; EXL-1 is localized to lysosomes in intestinal cells and coelomocytes, endoplasmic reticulum in coelomocytes, Golgi apparatus in muscle and the neurons PVD and CAN, plasma membrane in muscle arms, and to dense bodies linking muscle cytoskeleton to hypodermis through muscle cell membranes; EXL-1 has an N-terminal PTM domain required for its membrane targeting, and a C-terminal domain resembling omega-type glutathione-S-transferases; EXL-1 has no known function in vivo, and exl-1(ok857) mutants have no obvious phenotype. Paper_evidence: WBPaper00006263
            WBPaper00027655
          Curator_confirmed: WBPerson567
          Date_last_updated: 18 Jan 2008 00:00:00
      Automated_description: Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Located in apical plasma membrane; cytoplasm; and muscle cell projection membrane. Expressed in coelomocyte; intestine; muscle cell; and neurons. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome. Is an ortholog of human CLIC2 (chloride intracellular channel 2) and CLIC4 (chloride intracellular channel 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00040625
          Curator_confirmed: WBPerson324
          Date_last_updated: 29 Apr 2019 00:00:00
    Potential_model: DOID:0060828 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2063)
  Models_disease_asserted: WBDOannot00000653
  Molecular_info: Corresponding_CDS: F26H11.5
    Corresponding_transcript: F26H11.5.1
    Other_sequence: Tcol_isotig00207
      CBC02920_1
      FD517449.1
      CSC01417_1
    Associated_feature: WBsf666366
      WBsf666367
      WBsf666368
      WBsf990706
      WBsf1013839
      WBsf224272
  Experimental_info: RNAi_result: WBRNAi00031474 Inferred_automatically: RNAi_primary
      WBRNAi00013985 Inferred_automatically: RNAi_primary
      WBRNAi00045703 Inferred_automatically: RNAi_primary
      WBRNAi00090593 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2810
      Expr9874
      Expr1015562
      Expr1030826
      Expr1149614
      Expr2011395
      Expr2029631
    Drives_construct: WBCnstr00010963
      WBCnstr00012955
      WBCnstr00014373
      WBCnstr00015737
      WBCnstr00036986
    Construct_product: WBCnstr00010963
      WBCnstr00012955
      WBCnstr00014373
      WBCnstr00015737
      WBCnstr00036986
    Microarray_results (17)
    Expression_cluster (121)
    Interaction (19)
  Map_info: Map: II Position: 22.9676 Error: 0.006188
    Positive: Positive_clone: F26H11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4590
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene