| WBGene00001309 | SMap | S_parent | Sequence | M01D7 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | emr-1 |
| | | Sequence_name | M01D7.6 |
| | | Molecular_name | M01D7.6 |
| | | | M01D7.6.1 |
| | | | CE12270 |
| | | | M01D7.6.2 |
| | | Other_name | CELE_M01D7.6 | Accession_evidence | NDB | BX284601 |
| | | Public_name | emr-1 |
| | DB_info | Database | AceView | gene | 1C315 |
| | | | WormQTL | gene | WBGene00001309 |
| | | | WormFlux | gene | WBGene00001309 |
| | | | OMIM | disease | 181350 |
| | | | | | 310300 |
| | | | | gene | 300384 |
| | | | NDB | locus_tag | CELE_M01D7.6 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001309|UniProtKB=O01971 |
| | | | | family | PTHR12019 |
| | | | NCBI | gene | 171752 |
| | | | RefSeq | protein | NM_058506.6 |
| | | | SwissProt | UniProtAcc | O01971 |
| | | | TREEFAM | TREEFAM_ID | TF340652 |
| | | | UniProt_GCRP | UniProtAcc | O01971 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | emr |
| | Allele (18) |
| | Strain | WBStrain00002843 |
| | | WBStrain00035605 |
| | | WBStrain00036376 |
| | | WBStrain00003842 |
| | RNASeq_FPKM (74) |
| | GO_annotation (14) |
| | Contained_in_operon | CEOP1992 |
| | Ortholog (12) |
| | Structured_description | Concise_description | emr-1 gene encodes a homolog of the human integral nuclear membrane protein emerin ; EMR-1 belongs to a family of proteins sharing the LEM-domain (LAP2-Emerin-MAN1 domain) that are generally conserved in metazoa and bind to lamin; EMR-1, along with another LEM-domain protein, LEM-2 is required for larval development, normal life-span, nuclear envelope and chromatin organization, chromosome segregation and cell division; emr-1 is also required for smooth muscle activity; emr-1 negatively regulates pha-4, the transcription factor required for pharynx identity; EMR-1 protein is found in the nuclear envelopes of all cell types except sperm and at all life stages; EMR-1 binds to lamin/LMN-1; emr-1 mutations also exhibit weak hypersensitivity to DNA damage. | Paper_evidence | WBPaper00004339 |
| | | | | | WBPaper00005158 |
| | | | | | WBPaper00005648 |
| | | | | | WBPaper00005828 |
| | | | | | WBPaper00040518 |
| | | | | | WBPaper00037040 |
| | | | | | WBPaper00040826 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 12 Apr 2012 00:00:00 |
| | | Automated_description | Enables lamin binding activity. Involved in several processes, including mitotic cytokinesis; nuclear envelope organization; and response to X-ray. Located in nuclear inner membrane. Used to study Emery-Dreifuss muscular dystrophy. Is an ortholog of human LEMD1 (LEM domain containing 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00044786 |
| | | | | Accession_evidence | OMIM | 181350 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 09 Oct 2017 00:00:00 |
| | Disease_relevance | Mutations in the human ortholog of emr-1, emerin, cause X-linked Emery-Dreifuss muscular dystrophy (EDMD); Emerin is a nuclear lamina protein and belongs to a family of LEM (LAP2-Emerin-MAN1) domain proteins that include MAN1, LEM2/NET25 and several others; LEM domain proteins bind lamin; mutations in human LMNA/lamin cause several laminopathic diseases including EDMD; much of the knowledge of the organization and assembly of the nuclear lamina has come from studies in elegans; studies in elegans have demonstrated the overlapping roles of emerin and lem-2 in embryogenesis, cell proliferation, lamin and heterochromatin organization; worm emerin and lem-2 are also involved in mitosis, smooth and striated muscle function, lifespan and meiotic progression, pointing to the many underlying processes that may affect disease phenotypes. | Homo sapiens | Paper_evidence | WBPaper00040268 |
| | | | | Accession_evidence | OMIM | 310300 |
| | | | | | | 300384 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 01 Mar 2012 00:00:00 |
| Models_disease_asserted | WBDOannot00000045 |
| Molecular_info | Corresponding_CDS | M01D7.6 |
| | Corresponding_transcript | M01D7.6.1 |
| | | M01D7.6.2 |
| | Other_sequence | GRC02002_1 |
| | | GPC01900_1 |
| | | CRC09112_1 |
| | | CR02292 |
| | | GP02519 |
| | | CBC09681_1 |
| | Associated_feature | WBsf982768 |
| | | WBsf982769 |
| | | WBsf217259 |
| Experimental_info | RNAi_result (12) |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00000686 |
| | | WBCnstr00000688 |
| | | WBCnstr00003365 |
| | | WBCnstr00018932 |
| | | WBCnstr00020603 |
| | | WBCnstr00020604 |
| | | WBCnstr00020605 |
| | | WBCnstr00037001 |
| | Construct_product (11) |
| | Regulate_expr_cluster | WBPaper00044786:emr-1(gk119)_downregulated |
| | | WBPaper00044786:emr-1(gk119)_upregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | Antibody | WBAntibody00000305 |
| | | WBAntibody00000306 |
| | | WBAntibody00000307 |
| | | WBAntibody00000597 |
| | | WBAntibody00001856 |
| | | WBAntibody00001941 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00028451:Low_abundance_spermatogenesis_enriched |
| | | WBPaper00029359_1124 |
| | | WBPaper00029359_1141 |
| | | WBPaper00029359_1227 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1304 |
| | | WBPaper00029359_1351 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1497 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1525 |
| | | WBPaper00029359_1604 |
| | | WBPaper00029359_1682 |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032097:CGH-1-associated-mRNA |
| | | WBPaper00032425:up_in_rde-4 |
| | | WBPaper00032425:up_in_zfp-1 |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040285:H2S_24hr_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046303:P.aeruginosa_downregulated_protein |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050686:glp-1(e2141)_downregulated |
| | | WBPaper00050743:elli-1(sam-3)_downregulated |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:nucleus_specific |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00052987:UV_upregulated_xpc-1;csb-1 |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster6 |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061274:hypergravity_10xg_upregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061340:Neuroblast_I6_M5 |
| | | WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3 |
| | | WBPaper00061340:Parent_of_g1P_I3 |
| | | WBPaper00061340:Parent_of_MI_pm1DR |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:dld-1-skn-1_16701 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064502:spe-44(fx110)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_2 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026952:class_A |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00032948:FedUp |
| | | WBPaper00035504:daf-2(e1370)_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00038060:SUMO-1_upregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_3d |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (84) |
| Map_info | Map | I | Position | -12.5332 | Error | 0.008453 |
| | Positive | Positive_clone | M01D7 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4286 |
| | | | 4536 |
| | Pseudo_map_position |
| Reference (35) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
