WormBase Tree Display for Gene: WBGene00001172

WBGene00001172 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C51E3
  Identity: Version: 1
    Name: CGC_name: egl-3 Person_evidence: WBPerson268
      Sequence_name: C51E3.7
      Molecular_name: C51E3.7a
        C51E3.7a.1
        CE08940
        C51E3.7c
        CE45708
        C51E3.7c.1
      Other_name: kpc-2
        pc2 Accession_evidence: EMBL U04995
        CELE_C51E3.7 Accession_evidence: NDB BX284605
      Public_name: egl-3
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (12)
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00036327
          Curator_confirmed: WBPerson324
          Date_last_updated: 06 Jun 2019 00:00:00
    Potential_model: DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8744)
      DOID:5844 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8744)
  Models_disease_asserted: WBDOannot00000710
  Molecular_info: Corresponding_CDS: C51E3.7a
      C51E3.7c
    Corresponding_CDS_history: C51E3.7b:wp261
    Corresponding_transcript: C51E3.7a.1
      C51E3.7c.1
    Other_sequence (127)
    Associated_feature (12)
  Experimental_info: RNAi_result (29)
    Expr_pattern (15)
    Drives_construct: WBCnstr00002351
      WBCnstr00004319
      WBCnstr00008114
      WBCnstr00018293
      WBCnstr00020688
      WBCnstr00037050
    Construct_product: WBCnstr00011520
      WBCnstr00017600
      WBCnstr00017601
      WBCnstr00021861
      WBCnstr00037050
    Antibody: WBAntibody00000429
    Microarray_results (30)
    Expression_cluster: WBPaper00024970:GABAergic_neuron_specific
      WBPaper00029359_1166
      WBPaper00029359_1194
      WBPaper00029359_1197
      WBPaper00029359_1240
      WBPaper00029359_1243
      WBPaper00029359_1291
      WBPaper00029359_1336
      WBPaper00029359_1546
      WBPaper00029359_1549
      WBPaper00029359_1557
      WBPaper00029359_1599
      WBPaper00030922:glycosylated_protein
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035211:age-1_vs_N2_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00045316:prg-1_upregulated_L4
      WBPaper00045521:Gender_Neutral
      WBPaper00045861:ash-2(tm1095)_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046858:elt-2(RNAi)_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_adult_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00052987:UV_upregulated_xpc-1;csb-1
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:nerve-ring_expressed
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059203:CAR-1_interacting
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059987:Wounding_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AFD
      WBPaper00061340:AIA
      WBPaper00061340:AIB
      WBPaper00061340:AIN
      WBPaper00061340:AIY
      WBPaper00061340:AVD
      WBPaper00061340:AVK
      WBPaper00061340:AVL
      WBPaper00061340:AWC
      WBPaper00061340:PVT
      WBPaper00061340:RIM
      WBPaper00061340:RIS
      WBPaper00061340:SIA
      WBPaper00061340:Z1_Z4
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:flp-5-F17C11.2
      WBPaper00061527:snt-4_17845-T27C4.1
      WBPaper00061651:ADA_enriched
      WBPaper00061651:AIA_enriched
      WBPaper00061651:AIB_enriched
      WBPaper00061651:AIM_enriched
      WBPaper00061651:AIN_enriched
      WBPaper00061651:AIY_enriched
      WBPaper00061651:AIZ_enriched
      WBPaper00061651:ALA_enriched
      WBPaper00061651:AVA_enriched
      WBPaper00061651:AVF_enriched
      WBPaper00061651:AVK_enriched
      WBPaper00061651:AVL_enriched
      WBPaper00061651:AVM_enriched
      WBPaper00061651:BAG_enriched
      WBPaper00061651:BDU_enriched
      WBPaper00061651:DVA_enriched
      WBPaper00061651:DVB_enriched
      WBPaper00061651:DVC_enriched
      WBPaper00061651:HSN_enriched
      WBPaper00061651:I5_enriched
      WBPaper00061651:IL2_LR_enriched
      WBPaper00061651:M1_enriched
      WBPaper00061651:MI_enriched
      WBPaper00061651:PDA_enriched
      WBPaper00061651:PVR_enriched
      WBPaper00061651:PVT_enriched
      WBPaper00061651:RIB_enriched
      WBPaper00061651:RID_enriched
      WBPaper00061651:RIF_enriched
      WBPaper00061651:RIG_enriched
      WBPaper00061651:RIH_enriched
      WBPaper00061651:RIR_enriched
      WBPaper00061651:RIS_enriched
      WBPaper00061651:RIV_enriched
      WBPaper00061651:RMG_enriched
      WBPaper00061651:RMH_enriched
      WBPaper00061651:SDQ_enriched
      WBPaper00061651:URB_enriched
      WBPaper00061651:URX_enriched
      WBPaper00061651:VC_4_5_enriched
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:AFD_enriched
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065623:94
      WBPaper00065623:100
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065841:68_0
      WBPaper00065841:68_1
      WBPaper00065841:74_0
      WBPaper00065841:92_0
      WBPaper00065841:97_0
      WBPaper00065841:103_0
      WBPaper00065841:104_0
      WBPaper00065841:105_0
      WBPaper00065841:107_0
      WBPaper00065841:112_0
      WBPaper00065841:121_0
      WBPaper00065841:122_0
      WBPaper00065841:123_0
      WBPaper00065841:128_0
      WBPaper00065841:129_0
      WBPaper00065841:134_0
      WBPaper00065841:144_0
      WBPaper00065841:145_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_14
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00027342:alpha-Synuclein(A53T)_downregulated
      WBPaper00028474:dys-1_downregulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032948:StarveUp3
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040821:Au-NP_regulated
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00042548:miRISC_enriched
      WBPaper00045865:biofilm_downregulated_B
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction (98)
    Anatomy_function: WBbtf0062
      WBbtf0209
      WBbtf0210
      WBbtf1042
  Map_info: Map: V Position: 2.28568 Error: 0.005714
    Well_ordered
    Positive: Inside_rearr: mDf1
      Positive_clone: C51E3 Person_evidence: WBPerson1139
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 715
      Multi_point: 329
        608
        609
        797
        953
        5581
      Pos_neg_data: 1732
        1733
        1734
        1741
  Reference (102)
  Remark: sequence connection from [Kass J, Kaplan JM]
    Sequence connection from [Thacker C]
    old_name kpc-2 becomes new_name egl-3 from [Thacker C].
  Method: Gene